2023
Levodopa for Dystonia in Children: A Case Series and Review of the Literature
DeArias A, Bamford N. Levodopa for Dystonia in Children: A Case Series and Review of the Literature. Pediatric Neurology 2023, 152: 16-19. PMID: 38176223, DOI: 10.1016/j.pediatrneurol.2023.12.012.Peer-Reviewed Original ResearchMotor functionMarsden Dystonia Rating ScaleLimited effective treatment optionsDystonia Rating ScaleEffective treatment optionForms of dystoniaLong-term treatmentShort-term useDopa-responsive dystoniaCarbidopa-levodopaBurke-FahnRetrospective reviewCase seriesHyperkinetic movementsTreatment optionsUntoward effectsExamination notesDystoniaSignificant causeLevodopaRating ScaleTrial periodChildrenTreatmentReviewA 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit
Berson E, Mozayan A, Peterec S, Taylor S, Bamford N, Ment L, Rowe E, Lisse S, Ehrlich L, Silva C, Goodman T, Payabvash S. A 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit. Frontiers In Neuroscience 2023, 17: 1132173. PMID: 36845429, PMCID: PMC9951115, DOI: 10.3389/fnins.2023.1132173.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitIntraventricular hemorrhageCare unitHypoxic injuryIntracranial pathologyAverage gestational ageParenchymal injuryPreterm neonatesCommon indicationIschemic lesionsNICU patientsGestational ageClinical findingsPatient weightInfantsTranscranial ultrasoundMRIInjuryCareMicrohemorrhagesScansLesionsFollowPathology
2022
Neonatal Human Parechovirus Encephalitis: A Case of Rapid and Fatal Gliosis
DeArias A, McAllister L, Bamford N. Neonatal Human Parechovirus Encephalitis: A Case of Rapid and Fatal Gliosis. Pediatric Neurology 2022, 140: 1-2. PMID: 36577180, DOI: 10.1016/j.pediatrneurol.2022.12.001.Peer-Reviewed Original ResearchAge-dependent white matter microstructural disintegrity in autism spectrum disorder
Weber CF, Lake EMR, Haider SP, Mozayan A, Mukherjee P, Scheinost D, Bamford NS, Ment L, Constable T, Payabvash S. Age-dependent white matter microstructural disintegrity in autism spectrum disorder. Frontiers In Neuroscience 2022, 16: 957018. PMID: 36161157, PMCID: PMC9490315, DOI: 10.3389/fnins.2022.957018.Peer-Reviewed Original ResearchAge-associated White Matter Microstructure and Connectome Abnormalities in Autism Spectrum Disorder
Weber C, Haider S, Mukherjee P, Lake E, Scheinost D, Bamford N, Ment L, Constable T, Payabvash S. Age-associated White Matter Microstructure and Connectome Abnormalities in Autism Spectrum Disorder. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/2100.Peer-Reviewed Original Research
2021
Ataxia
Bamford N, Cardinale K. Ataxia. 2021 DOI: 10.1891/9780826143990.0004.Peer-Reviewed Original ResearchControl of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons
Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, Grandes P, Lovinger DM, Stella N. Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons. European Journal Of Neuroscience 2021, 54: 4934-4952. PMID: 34216157, PMCID: PMC9377695, DOI: 10.1111/ejn.15381.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsR KO miceAmphetamine sensitizationKO miceMotor coordinationSpiny neuronsImpaired motor coordinationInvolvement of CBCannabinoid 1 receptorCannabinoid CB1 receptorsCB1 receptorsNeuronal subpopulationsCannabimimetic responsesInhibitory neuronsSpontaneous locomotionR activationR expressionMiceMouse linesKnockout backgroundNeuronsSpecific CBNew functional roleSensitizationDifferent behavioral responsesHarry T. Chugani
Bamford N. Harry T. Chugani. 2021, 666-668. DOI: 10.1016/b978-0-12-821635-4.00174-0.Peer-Reviewed Original ResearchArnold P. Gold
Bamford N, De Vivo D. Arnold P. Gold. 2021, 742-744. DOI: 10.1016/b978-0-12-821635-4.00116-8.Peer-Reviewed Original Research
2020
Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Shi Z, Bamford IJ, McKinley JW, Devi SPS, Vahedipour A, Bamford NS. Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice. Brain Sciences 2020, 10: 903. PMID: 33255421, PMCID: PMC7760026, DOI: 10.3390/brainsci10120903.Peer-Reviewed Original ResearchL-DOPA-induced dyskinesiaL-DOPAStriatal acetylcholineDA deficiencyMovement disordersDA availabilityHypokinetic movement disordersStriatal cholinergic interneuronsHyperkinetic movement disordersDopa decarboxylase inhibitorElectrophysiological experimentsOpen field testingStriatal ChIsParkinsonian miceCholinergic interneuronsMotor dysfunctionTherapeutic optionsMotor hyperactivityParadoxical riseDA ratioMotor functionDecarboxylase inhibitorDopamine insufficiencyΒ-ARsΒ-ARThe President, Past President, Executive Director, and the Board of the Child Neurology Society Denounce Racism and Inequality
Pearl P, Mink J, Cohen B, Bamford N, Bass N, Jordan L, Wainwright M, Larson R. The President, Past President, Executive Director, and the Board of the Child Neurology Society Denounce Racism and Inequality. Annals Of Neurology 2020, 88: 209-210. PMID: 32567711, DOI: 10.1002/ana.25828.Peer-Reviewed Original Research
2019
Localising movement disorders in childhood
Bamford NS, McVicar K. Localising movement disorders in childhood. The Lancet Child & Adolescent Health 2019, 3: 917-928. PMID: 31653548, PMCID: PMC7102738, DOI: 10.1016/s2352-4642(19)30330-x.Peer-Reviewed Original ResearchConceptsMovement disordersBasal gangliaBasal ganglia functionMajor movement disordersGanglia functionNew pharmacologicalTreatment decisionsClinical definitionSynaptic functionElectrophysiological approachesDisordersMotor learningGangliaChildrenIon channelsThalamusCortexPharmacologicalDiseasePhysiological frameworkDiagnosisNeuronsReceptorsRole of KCNQ potassium channels in stress-induced deficit of working memory
Arnsten AFT, Jin LE, Gamo NJ, Ramos B, Paspalas CD, Morozov YM, Kata A, Bamford NS, Yeckel MF, Kaczmarek LK, El-Hassar L. Role of KCNQ potassium channels in stress-induced deficit of working memory. Neurobiology Of Stress 2019, 11: 100187. PMID: 31832507, PMCID: PMC6889760, DOI: 10.1016/j.ynstr.2019.100187.Peer-Reviewed Original ResearchStress-induced deficitsKCNQ potassium channelsKCNQ blockersPrefrontal cortexNeuronal firingLayers II/IIIRat medial prefrontal cortexStress exposurePotassium channelsRat medial PFCMedial PFCChronic stress exposurePatch-clamp recordingsPyramidal cell firingMedial prefrontal cortexSystemic administrationPyramidal cellsAged ratsLow dosePFC dysfunctionHigh dosesKCNQ channelsLow dosesCell firingCognitive functionDopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease. Neuron 2019, 103: 1056-1072.e6. PMID: 31324539, PMCID: PMC7102938, DOI: 10.1016/j.neuron.2019.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAmphetamineAnimalsCholinergic NeuronsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMiceNeostriatumParkinson DiseasePatch-Clamp TechniquesReceptors, Dopamine D1Receptors, Dopamine D2Transcription, GeneticConceptsParkinson's diseaseDA deficiencyACh availabilityD1-type DA receptorsHyperpolarization-activated cation channelsRelease of acetylcholineStriatal acetylcholineDA receptorsStriatal interneuronsMotor deficitsDopamine deficiencyDA releasePharmacological treatmentResidual axonsStriatal synapsesMotor functionInterneuron functionAcetylcholineCognitive functionHCN channelsDiseaseCation channelsDopamineSpike timingDeficiencyCorticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitationCorrespondence Reply to Kitaoka et al.
Bamford NS. Correspondence Reply to Kitaoka et al. Pediatric Neurology 2019, 98: 95. PMID: 31113714, DOI: 10.1016/j.pediatrneurol.2019.04.006.Peer-Reviewed Original ResearchStriatal Acetylcholine and Dopamine are Necessary for Motor Function in Parkinsonism (P5.8-001)
Bamford N, McKinley J, Shi Z. Striatal Acetylcholine and Dopamine are Necessary for Motor Function in Parkinsonism (P5.8-001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.8-001.Peer-Reviewed Original ResearchL-Dopa-Induced Dyskinesias are Reduced by Propranolol in Parkinsonian Mice (P5.8-002)
Bamford N, Shi Z, Bamford I, Mckinley J. L-Dopa-Induced Dyskinesias are Reduced by Propranolol in Parkinsonian Mice (P5.8-002). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.8-002.Peer-Reviewed Original ResearchChondrodysplasia Punctata: A Clue to the Zellweger Spectrum Disorders
Bamford NS. Chondrodysplasia Punctata: A Clue to the Zellweger Spectrum Disorders. Pediatric Neurology 2019, 95: 84-85. PMID: 30898411, DOI: 10.1016/j.pediatrneurol.2019.01.013.Peer-Reviewed Original ResearchThe Striatum’s Role in Executing Rational and Irrational Economic Behaviors
Bamford IJ, Bamford NS. The Striatum’s Role in Executing Rational and Irrational Economic Behaviors. The Neuroscientist 2019, 25: 475-490. PMID: 30678530, PMCID: PMC6656632, DOI: 10.1177/1073858418824256.Peer-Reviewed Original ResearchConceptsIrrational economic behaviorExecutive functionStriatum's roleMotor learningMotor movementsSensory stimulationExcitatory glutamatergic activityBehavioral economicsHabit formationNovel stimulationNeural pathwaysReflexive actionDecision makingReflexive movementsRational behaviorEconomic behaviorRational responseRewardDopamine releaseBehaviorStriatumGlutamatergic activityLearningCortexThalamus