Jessica Magid-Bernstein, MD, PhD
Assistant Professor of NeurologyDownloadHi-Res Photo
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About
Titles
Assistant Professor of Neurology
Biography
Dr. Magid-Bernstein completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Appointments
Education & Training
- Fellow
- NY Presbyterian - Columbia University Medical Center/Weill Cornell Medicine (2021)
- Resident
- NY Presbyterian - Columbia University Medical Center (2019)
- Intern
- NY Presbyterian - Columbia University Medical Center (2016)
- MD
- Rutgers University - New Jersey Medical School (2015)
- PhD
- University of Medicine and Dentistry of NJ - New Jersey Medical School (2013)
- BA
- Haverford College (2006)
Research
Overview
Medical Research Interests
Cerebral Intraventricular Hemorrhage; Inflammation; Intracranial Hemorrhages; Subarachnoid Hemorrhage
ORCID
0000-0001-6506-6017
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jessica Magid-Bernstein's published research.
Publications Timeline
A big-picture view of Jessica Magid-Bernstein's research output by year.
Research Interests
Research topics Jessica Magid-Bernstein is interested in exploring.
Kevin Sheth, MD
Adam de Havenon, MD, MSCI
Emily J. Gilmore, MD, FNCS, FACNS
Guido J. Falcone, MD, ScD, MPH
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Charles Matouk, MD
24Publications
466Citations
Subarachnoid Hemorrhage
Publications
Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024 PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchAltmetricConceptsRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristicsExploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004)
Olexa M, Begunova Y, Gilmore E, Kim J, Herman A, Beekman R, Magid-Bernstein J, Matouk C, Sheth K, Miller E, Gutierrez S, De Havenon A, Sansing L, Petersen N. Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205692.Peer-Reviewed Original ResearchPrognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010)
Wang E, Misra S, Yan J, Chook P, Kawamura Y, Kitagawa R, Kim J, Gilmore E, De Havenon A, Sivaraju A, Hirsch L, Falcone G, Sansing L, Magid-Bernstein J, Mishra N. Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204783.Peer-Reviewed Original ResearchAssessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019)
Jayasundara S, Kim J, Choi R, Rapuano A, Barnes E, Parasram M, Moura M, Uppal P, Chen Y, Top I, Olexa M, Maarek R, Yan J, Beekman R, Magid-Bernstein J, Hebert R, Bahrassa F, Matouk C, Sheth K, Gilmore E, Petersen N. Assessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206285.Peer-Reviewed Original Research
2023
ABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage
Poyraz F, Ridha M, Simonetto M, Kumar A, Hess E, Magid-Bernstein J, Connolly E, Ghoshal S, Agarwal S, Park S, Claassen J, Hod E, Roh D. ABO-Incompatible Platelet Transfusion Is Associated with Ischemic Lesions on Brain MRI in Patients with Intracerebral Hemorrhage. Blood 2023, 142: 1288. DOI: 10.1182/blood-2023-186171.Peer-Reviewed Original ResearchConceptsABO-incompatible platelet transfusionsAcute ischemic brain lesionsIschemic brain lesionsIschemic lesionsPlatelet transfusionsICH patientsBrain MRIPlatelet unitsICH hospitalizationsICH severityBrain lesionsICH symptom onsetIncompatible platelet transfusionsProspective cohort studyAcute ischemic lesionsSpontaneous ICH patientsIntracerebral hemorrhage outcomesConsecutive spontaneous ICH patientsPatient's blood typeCerebral microthrombosisCohort studySymptom onsetRegression modelsClinical outcomesImpaired hemostasisGuidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage
Parasram M, Park J, Al-Dulaimi M, Magid-Bernstein J. Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Stroke 2023, 54: e508-e511. PMID: 37842781, DOI: 10.1161/strokeaha.123.044793.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesConceptsMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilation
Clinical Trials
Current Trials
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
HIC ID2000031665RolePrincipal InvestigatorPrimary Completion Date12/01/2025Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2024Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
activity BMC Neurology
Journal ServiceReviewerDetails2020 - Presentactivity Hypertension
Journal ServiceReviewerDetails2020 - Presentactivity Neurohospitalst
Journal ServiceReviewerDetails2020 - Presentactivity Neurocritical Care
Journal ServiceReviewerDetails2021 - Presentactivity Journal of the American Heart Association
Journal ServiceReviewerDetails2020 - Present
Clinical Care
Overview
Jessica Magid-Bernstein, MD, PhD, completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ, in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Clinical Specialties
Neurology; Neurocritical Care
Board Certifications
Neurocritical Care
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 2022
Neurology
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 2019
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Locations
Yale Neurology
Academic Office
100 York Street, Ste Suite 1N
New Haven, CT 06511