Andrea Roberts, MD
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About
Research
Publications
2025
Response to Lehrer
Roberts A, Kubzansky L, Tworoger S. Response to Lehrer. Journal Of The National Cancer Institute 2025, djaf044. PMID: 40036193, DOI: 10.1093/jnci/djaf044.Peer-Reviewed Original ResearchEarly-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study
Roberts A, Qiu X, McAlaine K, Germine L, Rotem R, Weisskopf M. Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study. Scientific Reports 2025, 15: 2105. PMID: 39814743, PMCID: PMC11736041, DOI: 10.1038/s41598-024-79083-x.Peer-Reviewed Original ResearchConceptsCognitively stimulating activitiesVisual short-term memoryCognitive functionWorking memoryShort-term memoryProcessing speedTests of crystallized intelligenceAssociated with specific cognitive domainsSpecific cognitive domainsVisual working memoryAssociated with higher cognitive functionOverall cognitive functionHigher cognitive functionsAssociated with overall cognitionLate-life cognitive functionAssociated with higher cognitive scoresCognitive controlEpisodic memoryVerbal reasoningCognitive domainsHigher cognitive scoresSustained attentionAssociated with activationOverall cognitionCognitive testsTiming of depression in relation to risk of ovarian cancer
Roberts A, Townsend M, Chibnik L, Kubzansky L, Tworoger S. Timing of depression in relation to risk of ovarian cancer. Journal Of The National Cancer Institute 2025, djae348. PMID: 39745894, DOI: 10.1093/jnci/djae348.Peer-Reviewed Original ResearchRisk of ovarian cancerAssociation of depressionAscertainment periodIncident cancerAssociated with greater cancer riskAssociated with increased risk of ovarian cancerAssociated with elevated riskTime of depressionAssociated with increased riskP-value thresholdCox proportional hazards modelsCancer ascertainmentProportional hazards modelCancer riskTests of statistical significanceStatistical significanceExamined depressionOvarian cancerElevated riskProspective cohortBehavioral factorsAscertainmentHazards modelConsecutive two-year periodDepression
2024
Association of Childhood Abuse With Incident Inflammatory Bowel Disease
Anyane-Yeboa A, Casey K, Roberts A, Lopes E, Burke K, Ananthakrishnan A, Richter J, Cozier Y, Koenen K, Chan A, Khalili H. Association of Childhood Abuse With Incident Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2024, 15: e00718. PMID: 39450870, PMCID: PMC11671083, DOI: 10.14309/ctg.0000000000000718.Peer-Reviewed Original ResearchIncident casesCohort of female health professionalsHazard ratios of CDNurses' Health Study IIIncident inflammatory bowel diseaseIncident cases of UCFemale health professionalsRisk of inflammatory bowel diseaseIncident cases of CDIncreased risk of CDInflammatory bowel diseaseRisk of Crohn's diseaseReview of medical recordsCox proportional hazards modelsDiagnosis of inflammatory bowel diseaseRisk of UCHealth professionalsStressful life eventsProportional hazards modelRisk of CDEmotional abuse subscaleSelf-reportHazard ratioLife stressorsStudy IINo association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study
Roberts A, Ratanatharathorn A, Chibnik L, Zhu Y, Jha S, Kang J, Wolf E, Kubzansky L, Koenen K. No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study. Brain Behavior And Immunity 2024, 123: 672-680. PMID: 39424013, PMCID: PMC11653203, DOI: 10.1016/j.bbi.2024.10.003.Peer-Reviewed Original ResearchPosttraumatic stress disorderBody mass indexAssociation of posttraumatic stress disorderPhysical activityDiet qualityAssociated with epigenetic agingEpigenetic ageAncestry principal componentsStress disorderReference group of womenHigher body mass indexLongitudinal cohort studySelf-reported raceCo-occurring depressionDiseases of agingCross-sectional analysisMiddle-aged womenGroup of womenAssociated with mortalityDepression statusHealth factorsLongitudinal associationsMid-lifeDunedinPoAmCohort studyAssociation between childhood abuse and risk of post-COVID-19 conditions: Results from three large prospective cohort studies
Vyas C, Wang S, Menor A, Kubzansky L, Slopen N, Rich-Edwards J, Chavarro J, Kang J, Roberts A. Association between childhood abuse and risk of post-COVID-19 conditions: Results from three large prospective cohort studies. Brain Behavior And Immunity 2024, 123: 143-150. PMID: 39191351, PMCID: PMC11698154, DOI: 10.1016/j.bbi.2024.08.046.Peer-Reviewed Original ResearchPost-COVID-19 conditionPost-COVID conditionsHealth-relatedPhysical/emotional abusePsychological factorsRisk of poor health outcomesGrowing Up Today StudyNurses' Health StudyPoor health outcomesAssociated with riskAssociated with increased riskChildhood abusePost-COVID-19COVID-19 surveyCOVID-19 questionnaireHealth outcomesHealth StudyProspective studyEmotional abuse subscaleSexual abuseSelf-reportCohort studyNo childhood abuseCOVID-19-related symptomsToday StudyPost-traumatic stress disorder symptom remission and cognition in a large cohort of civilian women – CORRIGENDUM
Liu J, Roberts A, Lawn R, Jha S, Sampson L, Sumner J, Kang J, Rimm E, Grodstein F, Liang L, Haneuse S, Kubzansky L, Koenen K, Chibnik L. Post-traumatic stress disorder symptom remission and cognition in a large cohort of civilian women – CORRIGENDUM. Psychological Medicine 2024, 54: 2312-2312. PMID: 38801090, DOI: 10.1017/s0033291724001107.Peer-Reviewed Original ResearchPrepandemic Resilience to Trauma and COVID-19 Infection in Older Women
Scoglio A, Choi K, Nishimi K, Sampson L, Koenen K, Roberts A, Jha S, Kubzansky L. Prepandemic Resilience to Trauma and COVID-19 Infection in Older Women. Psychosomatic Medicine 2024, 86: 625-632. PMID: 38573019, PMCID: PMC11371542, DOI: 10.1097/psy.0000000000001304.Peer-Reviewed Original ResearchPsychological resilienceSelf-reportLifetime trauma exposureAssociated with lower riskLow psychological resilienceTrauma exposureCOVID-19-related risk factorsLifetime traumaPsychosocial interventionsNurses' Health Study IIPsychological healthPsychological assetsImprove health outcomesLow riskPhysical healthResilience scoresProtective factorsStudy IIPositive COVID-19 test resultSymptomsCOVID-19 test resultsHealth outcomesCohort participantsCOVID-19 infectionSocio-demographicGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, Daskalakis N, Duncan L, Polimanti R, Aaronson C, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegoviç E, Babić D, Bacanu S, Baker D, Batzler A, Beckham J, Belangero S, Benjet C, Bergner C, Bierer L, Biernacka J, Bierut L, Bisson J, Boks M, Bolger E, Brandolino A, Breen G, Bressan R, Bryant R, Bustamante A, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum A, Børte S, Cahn L, Calabrese J, Caldas-de-Almeida J, Chatzinakos C, Cheema S, Clouston S, Colodro-Conde L, Coombes B, Cruz-Fuentes C, Dale A, Dalvie S, Davis L, Deckert J, Delahanty D, Dennis M, Desarnaud F, DiPietro C, Disner S, Docherty A, Domschke K, Dyb G, Kulenović A, Edenberg H, Evans A, Fabbri C, Fani N, Farrer L, Feder A, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gelaye B, Gelernter J, Geuze E, Gillespie C, Goleva S, Gordon S, Goçi A, Grasser L, Guindalini C, Haas M, Hagenaars S, Hauser M, Heath A, Hemmings S, Hesselbrock V, Hickie I, Hogan K, Hougaard D, Huang H, Huckins L, Hveem K, Jakovljević M, Javanbakht A, Jenkins G, Johnson J, Jones I, Jovanovic T, Karstoft K, Kaufman M, Kennedy J, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kotov R, Kranzler H, Krebs K, Kremen W, Kuan P, Lawford B, Lebois L, Lehto K, Levey D, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lu Y, Luft B, Lupton M, Luykx J, Makotkine I, Maples-Keller J, Marchese S, Marmar C, Martin N, Martínez-Levy G, McAloney K, McFarlane A, McLaughlin K, McLean S, Medland S, Mehta D, Meyers J, Michopoulos V, Mikita E, Milani L, Milberg W, Miller M, Morey R, Morris C, Mors O, Mortensen P, Mufford M, Nelson E, Nordentoft M, Norman S, Nugent N, O’Donnell M, Orcutt H, Pan P, Panizzon M, Pathak G, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Porjesz B, Powers A, Qin X, Ratanatharathorn A, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Runz H, Rutten B, de Viteri S, Salum G, Sampson L, Sanchez S, Santoro M, Seah C, Seedat S, Seng J, Shabalin A, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stensland S, Stevens J, Sumner J, Teicher M, Thompson W, Tiwari A, Trapido E, Uddin M, Ursano R, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt F, Werge T, Williams M, Williamson D, Winsvold B, Winternitz S, Wolf C, Wolf E, Xia Y, Xiong Y, Yehuda R, Young K, Young R, Zai C, Zai G, Zervas M, Zhao H, Zoellner L, Zwart J, deRoon-Cassini T, van Rooij S, van den Heuvel L, Stein M, Ressler K, Koenen K. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 2024, 56: 792-808. PMID: 38637617, PMCID: PMC11396662, DOI: 10.1038/s41588-024-01707-9.Peer-Reviewed Original ResearchConceptsMeta-analysis of genome-wide association studiesGenome-wide significant lociMulti-ancestry meta-analysisGenome-wide association analysisGenome-wide association studiesIndividuals of European ancestryPotential causal genesNative American ancestryMulti-omics approachPost-traumatic stress disorderAdmixed individualsSignificant lociRisk lociCausal genesAssociation studiesAssociation analysisFunctional genesTranscription factorsGenetic studiesAmerican ancestryEuropean ancestryAxon guidanceSynaptic structureLociGenesMultigenerational association between smoking and autism spectrum disorder: findings from a nationwide prospective cohort study
Yim G, Roberts A, Lyall K, Ascherio A, Weisskopf M. Multigenerational association between smoking and autism spectrum disorder: findings from a nationwide prospective cohort study. American Journal Of Epidemiology 2024, 193: 1115-1126. PMID: 38583942, PMCID: PMC11299032, DOI: 10.1093/aje/kwae038.Peer-Reviewed Original ResearchGrandmother's smokingMother's smokingNurses' Health Study IICohort study subgroupProspective cohort studyNursing reportsOdds ratioNursesCohort studyStudy IISmokingExposure to cigarette smokeCigarette smokingAutism spectrum disorderStudy subgroupsMothersPregnancyMultiple subsequent generationsSpectrum disorderGrandmothersAssociationGrandchildrenAOROddsExposure to environmental insults