The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol.
Ackermans M, Pereira Arias A, Bisschop P, Endert E, Sauerwein H, Romijn J. The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 2220-6. PMID: 11344230, DOI: 10.1210/jcem.86.5.7383.Peer-Reviewed Original ResearchConceptsEndogenous glucose productionHealthy menInfusion of [6,6-(2)H(2)]glucoseHealthy postabsorptive malesInfusion of glycerolEucaloric conditionsPrimed continuous infusionContinuous infusionOral administrationInfusionRate of gluconeogenesisMeasure gluconeogenesisGluconeogenesisPrecursor poolAdministration