2021
Trends in ICD Implantations and in-Hospital Outcomes After DOJ Investigation
Bourdillon PM, Parzynski CS, Minges KE, Curtis JP, Desai NR. Trends in ICD Implantations and in-Hospital Outcomes After DOJ Investigation. Journal Of Cardiac Failure 2021, 28: 154-160. PMID: 34628015, DOI: 10.1016/j.cardfail.2021.09.010.Peer-Reviewed Original ResearchConceptsHospital adverse eventsHospital outcomesAdverse eventsHeart failureMyocardial infarctionRecent acute myocardial infarctionPlacement of ICDsPrimary prevention ICDsAdverse event ratesRecent myocardial infarctionAcute myocardial infarctionHigh mortality rateICD implantationRecent diagnosisMortality ratePatientsICDInfarctionHospitalOutcomesRapid reductionUse of devicesFailureSpecific reasonsCriteriaComparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e010323. PMID: 34372676, PMCID: PMC8485756, DOI: 10.1161/circinterventions.120.010323.Peer-Reviewed Original Research
2018
Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014
Goldsweig AM, Wang Y, Forrest JK, Cleman MW, Minges KE, Mangi AA, Aronow HD, Krumholz HM, Curtis JP. Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014. Catheterization And Cardiovascular Interventions 2018, 92: 1104-1115. PMID: 29513365, DOI: 10.1002/ccd.27576.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionVentricular septal ruptureTimely primary PCIMortality ratePrimary PCIPercutaneous repairSeptal ruptureMyocardial infarctionRetrospective cohort studyUnadjusted mortality ratesUnrepaired patientsVSR repairFatal complicationCohort studyAnnual incidenceMedicare feeService beneficiariesPatientsIncidenceStudy periodMortalityHospitalizationInfarctionRepairPCI
2016
Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study
Minges KE, Strait KM, Owen N, Dunstan DW, Camhi SM, Lichtman J, Geda M, Dreyer RP, Bueno H, Beltrame JF, Curtis JP, Krumholz HM. Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study. European Journal Of Preventive Cardiology 2016, 24: 192-203. PMID: 27885060, DOI: 10.1177/2047487316679905.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAustraliaCardiac RehabilitationChi-Square DistributionExerciseExercise TherapyFemaleHealth BehaviorHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMyocardial InfarctionOdds RatioPatient ComplianceProspective StudiesRisk FactorsSex FactorsSpainTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsAcute myocardial infarctionPost-acute myocardial infarctionMyocardial infarctionPhysical activityRegular physical activity participationYoung AMI Patients (VIRGO) studyPhysical activity recommendationsAmerican Heart AssociationPhysical activity trajectoriesNon-white raceMyocardial infarction recoveryPhysical activity participationGender differencesHospital dischargeHeart AssociationLifestyle behaviorsActivity recommendationsObservational studyInfarctionAustralian hospitalsTargeted interventionsOne monthPatientsTime pointsLonger duration
2012
Development of 2 Registry-Based Risk Models Suitable for Characterizing Hospital Performance on 30-Day All-Cause Mortality Rates Among Patients Undergoing Percutaneous Coronary Intervention
Curtis JP, Geary LL, Wang Y, Chen J, Drye EE, Grosso LM, Spertus JA, Rumsfeld JS, Weintraub WS, Masoudi FA, Brindis RG, Krumholz HM. Development of 2 Registry-Based Risk Models Suitable for Characterizing Hospital Performance on 30-Day All-Cause Mortality Rates Among Patients Undergoing Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2012, 5: 628-637. PMID: 22949491, DOI: 10.1161/circoutcomes.111.964569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAngina PectorisChi-Square DistributionComorbidityFemaleHeart DiseasesHospital MortalityHospitalsHumansLogistic ModelsMaleMyocardial InfarctionOdds RatioOutcome and Process Assessment, Health CarePercutaneous Coronary InterventionQuality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsShock, CardiogenicTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionRisk-standardized mortality ratesElevation myocardial infarctionPatient mortality ratesMyocardial infarctionMortality rateCardiogenic shockCoronary interventionDerivation cohortHospital risk-standardized mortality ratesCause mortality ratesAdministrative claims dataQuality of careHierarchical logistic regression modelsNational Quality ForumLogistic regression modelsObserved mortality rateCathPCI RegistryNational HospitalClaims dataInfarctionPatientsQuality ForumFinal modelBleeding-Avoidance Strategies and Outcomes in Patients ≥80 Years of Age With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the NCDR CathPCI Registry)
Dodson JA, Wang Y, Chaudhry SI, Curtis JP. Bleeding-Avoidance Strategies and Outcomes in Patients ≥80 Years of Age With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the NCDR CathPCI Registry). The American Journal Of Cardiology 2012, 110: 1-6. PMID: 22475362, PMCID: PMC3666171, DOI: 10.1016/j.amjcard.2012.02.039.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIBleeding-avoidance strategiesST-segment elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionMyocardial infarctionCoronary interventionUndergoing primary percutaneous coronary interventionST-elevation myocardial infarctionDirect thrombin inhibitorVascular closure deviceYears of ageBleeding complicationsCathPCI RegistryMultivariable analysisRadial accessClosure deviceHigh riskBleedingPatientsThrombin inhibitorsInfarctionLow bleedingStudy period
2011
Improvements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarction
2010
Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization
Chen J, Krumholz HM, Wang Y, Curtis JP, Rathore SS, Ross JS, Normand SL, Schreiner GC, Mulvey G, Nallamothu BK. Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization. JAMA Internal Medicine 2010, 170: 433-439. PMID: 20212179, PMCID: PMC2900156, DOI: 10.1001/archinternmed.2009.538.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesNon-PCI hospitalsPercutaneous coronary interventionAcute myocardial infarctionHospital referral regionsPCI hospitalsHealth care regionCoronary interventionAMI patientsMyocardial infarctionCare regionLower risk-standardized mortality ratesSame hospital referral regionService beneficiaries 65 yearsBeneficiaries 65 yearsMagnitude of benefitPatient survivalAMI careReferral regionsOutcome differencesMedicare feeMortality rateHospitalHospital capabilitiesInfarction
2009
National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistryAssociation of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatment
2008
Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Lichtman JH, Nallamothu BK, Sullivan MD, Gersh BJ, Roger VL, Curtis JP, Krumholz HM. Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction. JAMA Internal Medicine 2008, 168: 959-968. PMID: 18474760, PMCID: PMC4858313, DOI: 10.1001/archinte.168.9.959.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionMyocardial infarctionHospital presentationSymptom onsetPatient subgroupsRisk factorsOnset of symptomsQuality of careRace/ethnicityNational registryPatient responsivenessInfarctionPatientsReference groupSubgroupsWomenMenCareOnsetMinutesPresentationYearsHoursGeometric meanDiabeticsDelay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Nallamothu BK, Gersh BJ, Roger VL, Lichtman JH, Curtis JP, Krumholz HM. Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction. The American Journal Of Medicine 2008, 121: 316-323. PMID: 18374691, PMCID: PMC2373574, DOI: 10.1016/j.amjmed.2007.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryEarly DiagnosisElectrocardiographyEmergency Medical ServicesEmergency Service, HospitalFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationOdds RatioProbabilityRegistriesRetrospective StudiesRisk FactorsSurvival AnalysisThrombolytic TherapyTime FactorsTreatment OutcomeConceptsST-elevation myocardial infarctionReperfusion therapyHospital presentationBalloon timeSymptom onsetLonger doorMyocardial infarctionDrug timePrimary reperfusion therapyCohort studyLate presentersNeedle timeNational registryPatientsReduced likelihoodTherapyInfarctionLong delayPresentationOnsetHoursAssociationMinutesRegistry
2007
Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, Rathore SS, Nallamothu BK, Peterson ED, Blaney ME, Frederick P, Krumholz HM. Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2007, 100: 1227-1232. PMID: 17920362, PMCID: PMC2715362, DOI: 10.1016/j.amjcard.2007.05.043.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArrhythmias, CardiacCaliforniaCohort StudiesEmergency Service, HospitalEmergency TreatmentFemaleFibrinolytic AgentsHospital MortalityHumansMaleMedical RecordsMyocardial InfarctionOutcome Assessment, Health CareRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNeedle timeFibrinolytic therapyMyocardial infarctionHospital mortalitySymptom onsetOdds ratioReperfusion strategyAdjunctive medicationsHospital arrivalShorter doorTimely administrationNational registryRepresentative cohortPatientsMortalityInfarctionTherapyIndependent effectsCohortMinutesSmaller centersOnsetImpact of delayImpact of the Food and Drug Administration’s Public Health Notification on the Adoption of Drug-Eluting Stents
Curtis JP, Cohen DJ, Jones PG, Bach RG, Spertus JA, Krumholz HM. Impact of the Food and Drug Administration’s Public Health Notification on the Adoption of Drug-Eluting Stents. The American Journal Of Cardiology 2007, 99: 1227-1229. PMID: 17478147, DOI: 10.1016/j.amjcard.2006.12.031.Peer-Reviewed Original ResearchConceptsPublic health notificationDrug-eluting stentsDES useDrug Administration Public Health NotificationsUse of DESDrug Administration NotificationProspective registryMyocardial infarctionDES safetyClinical practiceStudy periodStentsRelative decreaseTemporary effectInfarctionPatientsNotificationFoodRegistryDramatic increase
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedback
2005
Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction
Portnay EL, Foody JM, Rathore SS, Wang Y, Masoudi FA, Curtis JP, Krumholz HM. Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2005, 46: 967-974. PMID: 16168277, PMCID: PMC2790536, DOI: 10.1016/j.jacc.2005.06.049.Peer-Reviewed Original ResearchConceptsPrior aspirin useCondition-specific readmissionAspirin useMyocardial infarctionCause readmissionMedicare beneficiariesSix-month mortalityAcute myocardial infarctionElderly patientsMultivariable adjustmentPrognostic significanceHigh riskReadmissionLower riskLower mortalityPatientsOne monthMortalityMonthsInfarctionOne-thirdNational sampleRiskMarkersAssociation
2004
Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3)
Curtis JP, Alexander JH, Huang Y, Wallentin L, Verheugt FW, Armstrong PW, Krumholz HM, Van de Werf F, Danays T, Cheeks M, Granger CB, Investigators A. Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3). The American Journal Of Cardiology 2004, 94: 279-283. PMID: 15276088, DOI: 10.1016/j.amjcard.2004.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedConfidence IntervalsDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationElectrocardiographyFemaleFollow-Up StudiesHeparin, Low-Molecular-WeightHumansIncidenceIntracranial HemorrhagesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial IschemiaPartial Thromboplastin TimeProbabilityRandomized Controlled Trials as TopicRisk AssessmentSeverity of Illness IndexSurvival RateTenecteplaseThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeConceptsWeight-adjusted heparinST-elevation myocardial infarctionASSENT-3Myocardial infarctionASSENT-2Major bleedingIntracranial hemorrhageSmall doseFull-dose tenecteplaseLess major bleedingNew thrombolytic regimenOutcomes of patientsAcute myocardial infarctionPartial thromboplastin timeSimilar ratesRefractory ischemiaThrombolytic regimenRecurrent infarctionBaseline characteristicsHemorrhagic complicationsUnfractionated heparinThromboplastin timePatientsInfarctionTenecteplase