2018
Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation
O'Brien EC, Holmes DN, Thomas LE, Fonarow GC, Allen LA, Gersh BJ, Kowey PR, Singer DE, Ezekowitz MD, Naccarelli GV, Ansell JE, Chan PS, Mahaffey KW, Go AS, Freeman JV, Reiffel JA, Peterson ED, Piccini JP, Hylek EM. Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation. Circulation 2018, 138: 889-897. PMID: 29678813, DOI: 10.1161/circulationaha.117.031354.Peer-Reviewed Original ResearchConceptsStroke/systemic embolismMajor bleedingOral anticoagulantsAtrial fibrillationMinor bleeding eventsSubset of patientsVASc risk scorePooled logistic regressionYears of ageBleeding eventsEligible followOAC discontinuationOAC therapyOutpatient registrySystemic embolismAnticoagulated patientsMinor bleedingMedian ageTreatment satisfactionPrognostic significanceNuisance bleedingMedical recordsORBIT-AFIncidence ratePatient visits
2006
Autonomic Nervous System Interaction With the Cardiovascular System During Exercise
Freeman JV, Dewey FE, Hadley DM, Myers J, Froelicher VF. Autonomic Nervous System Interaction With the Cardiovascular System During Exercise. Progress In Cardiovascular Diseases 2006, 48: 342-362. PMID: 16627049, DOI: 10.1016/j.pcad.2005.11.003.Peer-Reviewed Original ResearchConceptsExercise testHR variabilityHR recoveryCardiovascular systemSudden cardiac deathAutonomic nervous system interactionsSignificant prognostic informationAutonomic nervous systemHeart rate responseStandard exercise testNervous system interactionsConsiderable recent evidenceExercise testingCardiac deathPrognostic significancePrognostic valuePrognostic informationCardiovascular patientsExercise measurementsHR responseNervous systemRate responseRecent evidenceExerciseFuture findings