2011
Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention
Khawaja FJ, Shah ND, Lennon RJ, Slusser JP, Alkatib AA, Rihal CS, Gersh BJ, Montori VM, Holmes DR, Bell MR, Curtis JP, Krumholz HM, Ting HH. Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 172: 112-117. PMID: 22123752, PMCID: PMC3688066, DOI: 10.1001/archinternmed.2011.569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryCoronary Artery BypassEducational StatusFemaleFollow-Up StudiesHeart FailureHumansIschemic Attack, TransientKidney DiseasesLength of StayMaleMedicareMultivariate AnalysisMyocardial InfarctionNeoplasm MetastasisPatient ReadmissionPeptic UlcerProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegistriesSex FactorsStrokeUnited StatesConceptsPercutaneous coronary interventionThirty-day readmissionReadmission ratesCoronary interventionHigh riskChronic obstructive pulmonary diseaseThirty-day readmission ratesCox proportional hazards modelMultivariate logistic regression modelTransient ischemic attackCongestive heart failureObstructive pulmonary diseasePeptic ulcer diseaseSevere renal diseaseAcute myocardial infarctionLength of stayMain outcome measuresProportional hazards modelSaint Mary's HospitalLogistic regression modelsIschemic attackTime-dependent covariatesUnstable anginaCerebrovascular accidentHeart failure
2009
Increased Mortality among Survivors of Myocardial Infarction with Kidney Dysfunction: the Contribution of Gaps in the use of Guideline-Based Therapies
Peterson PN, Ambardekar AV, Jones PG, Krumholz HM, Schelbert E, Spertus JA, Rumsfeld JS, Masoudi FA. Increased Mortality among Survivors of Myocardial Infarction with Kidney Dysfunction: the Contribution of Gaps in the use of Guideline-Based Therapies. BMC Cardiovascular Disorders 2009, 9: 29. PMID: 19586550, PMCID: PMC2716301, DOI: 10.1186/1471-2261-9-29.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidney DiseasesMaleMiddle AgedMyocardial InfarctionPractice Guidelines as TopicProportional Hazards ModelsProspective StudiesRegistriesRisk AssessmentSeverity of Illness IndexSurvivorsTime FactorsTreatment OutcomeUnited StatesConceptsGlomerular filtration rateAcute myocardial infarctionGuideline-based medical therapyGuideline-based therapyMedical therapyKidney dysfunctionMyocardial infarctionUse of guidelinesEligible patientsRenal dysfunctionHazard ratioCox regressionPathophysiological abnormalitiesClinical variablesKidney diseaseFiltration rateNovel therapiesUS CentersHigh mortalityPatientsTherapyFurther adjustmentMortalityDysfunctionTreatment factors
2007
Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction
Smith GL, Masoudi FA, Shlipak MG, Krumholz HM, Parikh CR. Renal Impairment Predicts Long-Term Mortality Risk after Acute Myocardial Infarction. Journal Of The American Society Of Nephrology 2007, 19: 141-150. PMID: 18003773, PMCID: PMC2391037, DOI: 10.1681/asn.2007050554.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRenal functionRenal impairmentCreatinine clearanceMortality riskMyocardial infarctionCockcroft-Gault creatinine clearanceLong-term mortality riskMild renal impairmentSevere renal impairmentNormal renal functionCohort of patientsCooperative Cardiovascular ProjectPatient ageSystolic functionHospitalized patientsPrognostic importanceRisk factorsPatientsMortalityImpairmentClearanceGFRInfarctionRiskAdverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials
Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM. Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials. JAMA Internal Medicine 2007, 167: 1930-1936. PMID: 17923591, DOI: 10.1001/archinte.167.18.1930.Peer-Reviewed Original ResearchConceptsAngiotensin II receptor blockersSymptomatic left ventricular dysfunctionLeft ventricular dysfunctionII receptor blockersVentricular dysfunctionAdverse effectsMedication discontinuationReceptor blockersSymptomatic hypotensionRenal functionACE inhibitorsClinical trialsRelative riskEnzyme inhibitorsAngiotensin converting enzyme (ACE) inhibitorsACE inhibitor therapyHealth clinical trialsChronic heart failureRandomized clinical trialsAcute myocardial infarctionConfidence intervalsRandom-effects modelSignificant increaseEligible RCTsHeart failure
2006
Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery
Parikh CR, Coca SG, Smith GL, Vaccarino V, Krumholz HM. Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery. JAMA Internal Medicine 2006, 166: 2014-2019. PMID: 17030836, DOI: 10.1001/archinte.166.18.2014.Peer-Reviewed Original ResearchConceptsSevere chronic kidney diseaseChronic kidney diseasePhysical functionMH scorePF scoresKidney diseaseMedical Outcomes Trust Short FormAdvanced chronic kidney diseaseCoronary artery bypass surgeryLife outcomesCoronary artery bypassPrimary end pointArtery bypass surgeryHealth-related qualityCoronary artery diseaseMH subscalesArtery bypassCKD stageBypass surgeryArtery diseaseHealth SurveyMean changeStage 0Mean decreaseCABGUnderrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease
Coca SG, Krumholz HM, Garg AX, Parikh CR. Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease. JAMA 2006, 296: 1377-1384. PMID: 16985230, DOI: 10.1001/jama.296.11.1377.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesHumansKidney DiseasesPatient SelectionRandomized Controlled Trials as TopicConceptsChronic congestive heart failureCongestive heart failureRenal diseaseRenal functionHeart failureSubgroup analysisCardiovascular diseaseCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAldosterone system antagonistsBaseline renal functionHeart Association guidelinesCardiovascular disease trialsCurrent American CollegeRandomized Controlled TrialsAcute myocardial infarctionEffects of interventionsRepresentation of patientsOriginal articlesBaseline characteristicsCardiovascular mortalityPatient characteristicsControlled TrialsPrognostic featuresMyocardial infarctionIncrease in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction
Jose P, Skali H, Anavekar N, Tomson C, Krumholz HM, Rouleau JL, Moye L, Pfeffer MA, Solomon SD, Investigators F. Increase in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction. Journal Of The American Society Of Nephrology 2006, 17: 2886-2891. PMID: 16928807, DOI: 10.1681/asn.2006010063.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionCaptopril groupCardiovascular riskRenal functionSerum creatininePotent independent risk factorVentricular Enlargement (SAVE) trialBaseline renal functionHeart failure populationComposite end pointIndependent risk factorSerum creatinine measurementsBaseline creatinineCardiovascular deathCardiovascular morbidityPlacebo groupRenal dysfunctionSystolic dysfunctionVentricular dysfunctionAdverse eventsPrognostic importanceFailure populationTherapeutic choiceRisk factorsRenal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis
Smith GL, Lichtman JH, Bracken MB, Shlipak MG, Phillips CO, DiCapua P, Krumholz HM. Renal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis. Journal Of The American College Of Cardiology 2006, 47: 1987-1996. PMID: 16697315, DOI: 10.1016/j.jacc.2005.11.084.Peer-Reviewed Original ResearchMeSH KeywordsCreatinineCystatinsGlomerular Filtration RateHeart FailureHumansKidney DiseasesPrevalenceRisk FactorsConceptsRenal impairmentHF patientsSevere impairmentRenal functionExcess mortalityMortality riskSystematic reviewAssociated mortality riskHeart failure patientsCause mortality riskPrecise risk estimatesCause mortalityFailure patientsDL increaseRisk stratificationTherapeutic strategiesPatientsMeta-AnalysisMortalityRisk estimatesImpairmentSystematic searchMin decreaseRiskCreatinine
2005
Race and Renal Impairment in Heart Failure
Smith GL, Shlipak MG, Havranek EP, Masoudi FA, McClellan WM, Foody JM, Rathore SS, Krumholz HM. Race and Renal Impairment in Heart Failure. Circulation 2005, 111: 1270-1277. PMID: 15769768, DOI: 10.1161/01.cir.0000158131.78881.d5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlack or African AmericanCohort StudiesComorbidityCreatinineDiabetes MellitusFemaleGlomerular Filtration RateHeart FailureHumansHypertensionInpatientsKidney DiseasesMaleMedicareMortalityMyocardial InfarctionPrognosisRetrospective StudiesRisk FactorsTreatment OutcomeWhite PeopleConceptsRenal impairmentHF patientsWhite patientsMortality riskRacial differencesElderly HF patientsSimilar racial differencesGlomerular filtration rateHeart failure patientsStriking racial disparitiesMagnitude of riskDistinct morbidityElevated creatinineFailure patientsRenal functionHeart failureHigher creatinineRenal diseaseBlack patientsOptimal therapyPrognostic indicatorFiltration rateMedicare patientsMortality burdenRepresentative cohort
2004
Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY.
Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Wang Y, Young JB, Krumholz HM. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY. American Heart Journal 2004, 147: 331-338. PMID: 14760333, DOI: 10.1016/j.ahj.2003.08.012.Peer-Reviewed Original ResearchConceptsFluid intake/outputHeart failureIntake/outputRenal functionHigh riskCalcium channel blocker useHistory of HFAssociation of medicationLoop diuretic dosesPredictors of WRFElevated creatinine levelEnzyme inhibitor useHeart failure treatmentCase-control studyUse of CCBGreater fluid lossHigher hematocrit levelsUncontrolled hypertensionBlocker useDiuretic dosesCreatinine levelsInhibitor useAcute treatmentDiabetes mellitusIndependent predictors
2003
Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of Cardiac Failure 2003, 9: 13-25. PMID: 12612868, DOI: 10.1054/jcaf.2003.3.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesConnecticutCreatinineFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidney DiseasesKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityStatistics as TopicStroke VolumeSurvival AnalysisConceptsCreatinine elevationRenal functionHeart failureAdverse outcomesRisk of deathNumber of patientsMagnitude of riskBaseline creatinineProspective cohortRisk factorsFunctional declineHigh riskPatientsCreatinineMortalityHospitalizationDeathDlImportant predictorRiskElevationMeaningful changeMaximum specificityOutcomesBetter definition