2023
Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease
Godoy L, Farkouh M, Austin P, Shah B, Qiu F, Jackevicius C, Wijeysundera H, Krumholz H, Ko D. Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. Journal Of The American College Of Cardiology 2023, 81: 2299-2311. PMID: 37316110, DOI: 10.1016/j.jacc.2023.04.021.Peer-Reviewed Original ResearchConceptsStable coronary artery diseaseCoronary artery diseaseBeta-blocker groupRecent myocardial infarctionHeart failureMyocardial infarctionCardiovascular eventsCoronary angiographyPrescription claimsObstructive coronary artery diseaseIndex coronary angiographyBeta-blocker therapyBeta-blocker useHeart failure hospitalizationElective coronary angiographyNew-user designMyocardial infarction hospitalizationsCause deathCardiovascular outcomesCause mortalityFailure hospitalizationCardioprotective benefitsArtery diseasePrimary outcomeIschemic heart
2020
Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction
Jackevicius CA, Krumholz HM, Ross JS, Koh M, Chong A, Austin PC, Stukel TA, Azizi P, Ko DT. Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction. Canadian Journal Of Cardiology 2020, 36: 1633-1640. PMID: 32416066, DOI: 10.1016/j.cjca.2020.01.024.Peer-Reviewed Original ResearchConceptsPrior myocardial infarctionMyocardial infarctionStable patientsPopulation-based observational studyAngina 1 yearDeath/hospitalizationHistory of revascularisationBeta-blocker useMajor cardiovascular eventsHospital discharge diagnosisUse of BBsIndividual end pointsContemporary clinical trialsYears of ageCardiovascular eventsIndex dateCohort studyComposite outcomeBB useHeart failureMedian agePrimary outcomeClinical outcomesAtrial fibrillationDischarge diagnosis
2008
Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use
Daugherty SL, Ho PM, Spertus JA, Jones PG, Bach RG, Krumholz HM, Peterson ED, Rumsfeld JS, Masoudi FA. Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use. JAMA Internal Medicine 2008, 168: 485-491. PMID: 18332293, DOI: 10.1001/archinte.168.5.485.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinContinuity of Patient CareEvidence-Based MedicineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProportional Hazards ModelsProspective StudiesRegistriesRegression AnalysisTreatment OutcomeConceptsAcute myocardial infarctionMedication useMyocardial infarctionMultivariable analysisEarly outpatientEvidence-based medication useProspective Registry Evaluating OutcomesSecondary analysisEarly Follow-upBeta-blocker useUse of aspirinCurrent guideline recommendationsPrimary care physiciansEvidence-based therapiesHigh rateEligible patientsStatin useClinical characteristicsHospital dischargePrimary outcomeCare physiciansGuideline recommendationsMedication prescriptionsFollow-upEvaluating Outcomes
2006
Regional Differences in Process of Care and Outcomes for Older Acute Myocardial Infarction Patients in the United States and Ontario, Canada
Ko DT, Krumholz HM, Wang Y, Foody JM, Masoudi FA, Havranek EP, You JJ, Alter DA, Stukel TA, Newman AM, Tu JV. Regional Differences in Process of Care and Outcomes for Older Acute Myocardial Infarction Patients in the United States and Ontario, Canada. Circulation 2006, 115: 196-203. PMID: 17190861, DOI: 10.1161/circulationaha.106.657601.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesTreatment patternsAMI patientsMortality rateOlder acute myocardial infarction patientsInvasive cardiac procedure useAcute myocardial infarction treatmentAcute myocardial infarction patientsBeta-blocker useCardiac catheterization useCardiac procedure useEnzyme inhibitor useMyocardial infarction patientsProcess of careService Medicare beneficiariesHealth care delivery systemSimilar treatment patternsMyocardial infarction treatmentCare delivery systemInvasive cardiac therapyBaseline characteristicsInhibitor useMedication useIllness severityRandomized trialsHospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality
Bradley EH, Herrin J, Elbel B, McNamara RL, Magid DJ, Nallamothu BK, Wang Y, Normand SL, Spertus JA, Krumholz HM. Hospital Quality for Acute Myocardial Infarction: Correlation Among Process Measures and Relationship With Short-term Mortality. JAMA 2006, 296: 72-78. PMID: 16820549, DOI: 10.1001/jama.296.1.72.Peer-Reviewed Original ResearchMeSH KeywordsAgedCenters for Medicare and Medicaid Services, U.S.Cross-Sectional StudiesHospital MortalityHospitalsHumansJoint Commission on Accreditation of Healthcare OrganizationsMedicareMyocardial InfarctionOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesRisk AssessmentUnited StatesConceptsAcute myocardial infarctionMortality rateMyocardial infarctionProcess measuresAngiotensin-converting enzyme inhibitor useRisk-standardized mortality ratesShort-term mortality rateBeta-blocker useEnzyme inhibitor useHospital performanceHospital-level variationShort-term mortalityQuality process measuresAspirin useCessation counselingHospital outcomesInhibitor useAMI patientsNational registryMedication measuresTherapy measuresHospital qualityInfarctionMedicaid ServicesJoint Commission
2005
Quality Improvement Efforts and Hospital Performance
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Quality Improvement Efforts and Hospital Performance. Medical Care 2005, 43: 282-292. PMID: 15725985, DOI: 10.1097/00005650-200503000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCross-Sectional StudiesDrug Utilization ReviewFemaleHospitalsHumansLeadershipMaleMedical Staff, HospitalMiddle AgedMyocardial InfarctionOrganizational CultureOutcome Assessment, Health CarePractice Patterns, Physicians'Quality Indicators, Health CareRegistriesTotal Quality ManagementUnited StatesConceptsAcute myocardial infarctionBeta-blocker prescription ratesQuality improvement effortsMyocardial infarctionBeta-blocker useHospital teaching statusCross-sectional studyQuality improvement interventionsPatient-level dataPhysician leadershipQuality of careHospital performanceHospital quality improvement effortsImprovement effortsQuality improvement strategiesPrescription ratesBorderline significanceNational registryAMI volumeUS hospitalsImprovement interventionsHospitalTeaching statusEvidence baseHigh/mediumThe generalizability of observational data to elderly patients was dependent on the research question in a systematic review
Gross CP, Garg PP, Krumholz HM. The generalizability of observational data to elderly patients was dependent on the research question in a systematic review. Journal Of Clinical Epidemiology 2005, 58: 130-137. PMID: 15680745, DOI: 10.1016/j.jclinepi.2004.10.001.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectIntracranial hemorrhageSystematic reviewBeta-blocker useElderly patientsAngiography useCommunity patientsAtrial fibrillationRisk factorsObservational studyOutcome measuresRCT dataPresentation delayGlobal UtilizationT-PAPatientsSimilar predictorsTreatment variationStudy questionsCCP dataGUSTOHemorrhageReviewFibrillationAbsolute rate
2004
Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction
Rathore SS, Masoudi FA, Havranek EP, Krumholz HM. Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction. The American Journal Of Medicine 2004, 117: 811-822. PMID: 15589484, PMCID: PMC2790535, DOI: 10.1016/j.amjmed.2004.06.034.Peer-Reviewed Original ResearchConceptsBeta-blocker useMyocardial infarctionWhite patientsCoronary revascularizationBlack patientsRacial differencesCardiac catheterization useLower crude ratesUse of aspirinDay of admissionHealth care useTreatment of patientsAcute myocardial infarctionService Medicare beneficiariesMedical record dataQuality of careElderly feeRevascularization useAspirin useMultivariable adjustmentElderly patientsCardiac catheterizationCardiac proceduresCare useCrude rateHospital-Level Performance Improvement
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Hospital-Level Performance Improvement. Medical Care 2004, 42: 591-599. PMID: 15167327, DOI: 10.1097/01.mlr.0000128006.27364.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAmerican Hospital AssociationCardiology Service, HospitalComorbidityDrug Utilization ReviewFemaleGeographyGuideline AdherenceHealth Care SurveysHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionPatient DischargeQuality Assurance, Health CareRegistriesSocioeconomic FactorsUnited StatesConceptsBeta-blocker useAcute myocardial infarctionHospital-level variationHospital characteristicsMyocardial infarctionBeta-blocker prescription ratesHospital-level changesHospital-level ratesAmerican Hospital Association Annual SurveyClinical characteristicsPrescription ratesNational registryAMI volumeHospital ratesRate of improvementImprovement rateTeaching statusIndividual hospitalsInfarctionHospitalNational surveyPercentage pointsTime periodUse ratesWeak predictor
2003
What Are Hospitals Doing to Increase Beta-Blocker Use?
Bradley EH, Holmboe ES, Wang Y, Herrin J, Frederick PD, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. What Are Hospitals Doing to Increase Beta-Blocker Use? The Joint Commission Journal On Quality And Patient Safety 2003, 29: 409-415. PMID: 12953605, DOI: 10.1016/s1549-3741(03)29049-3.Peer-Reviewed Original ResearchConceptsBeta-blocker useQuality improvement interventionsMyocardial infarctionCare coordinatorsClinical pathwayImprovement interventionsAcute myocardial infarctionCross-sectional analysisQuality improvement staffQuality improvement effortsNational registryMedian numberHospitalTelephone surveyInfarctionReminder FormInterventionImprovement effortsRegistryPrevalencePathwayPhysicians
2002
β-Blocker Therapy in Heart Failure: Scientific Review
Foody JM, Farrell MH, Krumholz HM. β-Blocker Therapy in Heart Failure: Scientific Review. JAMA 2002, 287: 883-889. PMID: 11851582, DOI: 10.1001/jama.287.7.883.Peer-Reviewed Original ResearchConceptsHeart failure patientsHeart failureClinical trialsFailure patientsClinical outcomesClass IIDrug Administration indicationsBeta-blocker usePrimary end pointΒ-blocker therapyScientific rationaleTreatment of patientsCare of patientsEnglish-language articlesPotential physiologic roleBasic science studiesClass of agentsSystolic dysfunctionMortality benefitPlacebo treatmentDATA EXTRACTIONClinical guidelinesSTUDY SELECTIONCurrent recommendationsPatients
2001
A Qualitative Study of Increasing β-Blocker Use After Myocardial Infarction: Why Do Some Hospitals Succeed?
Bradley EH, Holmboe ES, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. A Qualitative Study of Increasing β-Blocker Use After Myocardial Infarction: Why Do Some Hospitals Succeed? JAMA 2001, 285: 2604-2611. PMID: 11368734, DOI: 10.1001/jama.285.20.2604.Peer-Reviewed Original ResearchConceptsBeta-blocker useAcute myocardial infarctionMyocardial infarctionΒ-blocker useStrong physician leadershipImprovement effortsUS hospitalsQualitative studyHospitalPatientsHospital sizeImprovement initiativesInfarctionKey physiciansGreater improvementPhysician leadershipCareAdministrative supportUse ratesPerformance improvement effortsData feedbackParticipantsGeographic regionsCliniciansMortality
1998
Improving the Quality of Care for Medicare Patients With Acute Myocardial Infarction: Results From the Cooperative Cardiovascular Project
Marciniak TA, Ellerbeck EF, Radford MJ, Kresowik TF, Gold JA, Krumholz HM, Kiefe CI, Allman RM, Vogel RA, Jencks SF. Improving the Quality of Care for Medicare Patients With Acute Myocardial Infarction: Results From the Cooperative Cardiovascular Project. JAMA 1998, 279: 1351-1357. PMID: 9582042, DOI: 10.1001/jama.279.17.1351.Peer-Reviewed Original ResearchMeSH KeywordsAlabamaCardiologyCardiology Service, HospitalConnecticutData CollectionHospital MortalityHospitalsHumansIowaMedicareMyocardial InfarctionPilot ProjectsProfessional Review OrganizationsQuality Assurance, Health CareQuality Indicators, Health CareStatistics, NonparametricSurvival AnalysisUnited StatesWisconsinConceptsAcute myocardial infarctionQuality of careMyocardial infarctionMedicare patientsBeta-blocker useAdministration of aspirinClinical practice guidelinesCooperative Cardiovascular ProjectLength of stayAcute care hospitalsQuality improvement projectQuality Improvement ProgramPilot statesPostinfarction mortalityAspirin useCessation counselingCare hospitalPeer review organizationsMedian lengthInpatient claimsPrincipal diagnosisPractice guidelinesInfarctionPatientsMortality comparisons