2017
The relationship between early childhood head injury and later life criminal behaviour: a longitudinal cohort study
Jackson T, Braun J, Mello M, Triche E, Buka S. The relationship between early childhood head injury and later life criminal behaviour: a longitudinal cohort study. Journal Of Epidemiology & Community Health 2017, 71: 800. PMID: 28663442, DOI: 10.1136/jech-2016-208582.Peer-Reviewed Original ResearchConceptsHead injuryChildhood Head InjurySevere head injuryHead injury casesLongitudinal cohort studyStatistical significanceMulticentre longitudinal studyAges 0Binomial regressionCollaborative Perinatal ProjectProvidence cohortCohort studyConduct problemsUninjured controlsPrenatal factorsChild healthInjury casesPerinatal ProjectInjuryNegative binomial regressionPropensity scoreYoung childhoodHealth recordsLongitudinal studyPsychological problems
2013
The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder
Viscidi E, Johnson A, Spence S, Buka S, Morrow E, Triche E. The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder. Autism 2013, 18: 996-1006. PMID: 24165273, PMCID: PMC4002664, DOI: 10.1177/1362361313508027.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism symptomsMaladaptive behaviorsAutism phenotypeHyperactivity symptomsSpectrum disorderMore autism symptomsCo-occurring intellectual disabilitySimons Simplex CollectionEpilepsy groupLower IQGreater impairmentMore irritabilityIntellectual disabilityIQChildrenImportant clinical implicationsClinical implicationsDisordersSymptomsBehaviorImpairmentIrritabilityImplicationsAssociationClinical Characteristics of Children with Autism Spectrum Disorder and Co-Occurring Epilepsy
Viscidi E, Triche E, Pescosolido M, McLean R, Joseph R, Spence S, Morrow E. Clinical Characteristics of Children with Autism Spectrum Disorder and Co-Occurring Epilepsy. PLOS ONE 2013, 8: e67797. PMID: 23861807, PMCID: PMC3701630, DOI: 10.1371/journal.pone.0067797.Peer-Reviewed Original ResearchConceptsPrevalence of epilepsyClinical characteristicsDevelopmental regressionOlder ageAverage prevalenceCo-occurring epilepsyAutism spectrum disorderDate of patientsMultivariate logistic regressionLarger patient populationCross-sectional studyPopulation-based samplePatient populationChildren ages 10Independent associationRisk factorsMultivariate regression modelSpectrum disorderEpilepsyAlert cliniciansSample of childrenLarger studyLogistic regressionPrevalenceAge 10Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism
Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Consortium S, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH, Devlin B, Morrow EM. Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism. American Journal Of Human Genetics 2013, 93: 103-109. PMID: 23830515, PMCID: PMC3710760, DOI: 10.1016/j.ajhg.2013.06.004.Peer-Reviewed Original ResearchConceptsGenome-wide analysisRare deleterious variantsDistinct genetic architecturesAutism candidate genesExome sequence dataGenetic architectureSingle geneROH burdenCandidate genesDeleterious variantsAutosomal recessive mutationSimplex autismGenesProportion of femalesIntellectual disabilityHomozygosityFamilyLociUnaffected siblingsMutationsAutism spectrum disorderFemalesProbandsVariants
2012
Implementing Provider‐based Sampling for the National Children's Study: Opportunities and Challenges
Belanger K, Buka S, Cherry DC, Dudley DJ, Elliott MR, Hale DE, Hertz‐Picciotto I, Illuzzi JL, Paneth N, Robbins JM, Triche EW, Bracken MB. Implementing Provider‐based Sampling for the National Children's Study: Opportunities and Challenges. Paediatric And Perinatal Epidemiology 2012, 27: 20-26. PMID: 23215706, DOI: 10.1111/ppe.12005.Peer-Reviewed Original ResearchConceptsNational Children's StudyProvider-based samplingChildren's StudyNational cohort studyPrenatal care providersNational probability sampleType of providerProbability sampleCohort studyPrenatal careCare providersChild healthProvider groupsAge 21Risk estimatesPrimary sampling unitsWomenBirthProvidersHealthSampling frameSecondary sampling unitsPregnancyNumber of strategiesUteroEffects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children
DellaValle CT, Triche EW, Leaderer BP, Bell ML. Effects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children. Epidemiology 2012, 23: 55-63. PMID: 22082997, PMCID: PMC3246281, DOI: 10.1097/ede.0b013e31823b66b8.Peer-Reviewed Original ResearchConceptsShortness of breathRescue medication useAsthma maintenance medicationsMaintenance medicationPersistent coughSensitized childrenChest tightnessNight symptomsAsthmatic childrenMedication usePollen exposureSeverity of asthmaDaily respiratory symptomsWeed pollenLogistic regression analysisLow exposureSeparate logistic regression analysesAsthmatic symptomsRespiratory symptomsDaily symptomsAntibiotic useSymptom outcomesDaily ambientMedicationsAmbient pollen concentrations
2011
Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1
Sordillo JE, Sharma S, Poon A, Lasky-Su J, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1. BMC Medical Genomics 2011, 12: 158. PMID: 22151743, PMCID: PMC3252252, DOI: 10.1186/1471-2350-12-158.Peer-Reviewed Original ResearchConceptsEndotoxin exposureAsthma riskProtective effectRisk of asthmaGenetic polymorphismsChildhood asthma riskChildhood Asthma StudyInnate immune pathwaysInnate immunity pathwaysAsthma StudyAsthmaConclusionOur findingsImmune pathwaysMinor alleleHome allergensImmunity pathwaysEczemaMajor alleleChildrenEndotoxinExposureRiskSignificant interactionPolymorphismACAA1Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth?
Wen X, Triche E, Hogan J, Shenassa E, Buka S. Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth? Pediatrics 2011, 127: e713-e721. PMID: 21300676, PMCID: PMC3065147, DOI: 10.1542/peds.2010-2000.Peer-Reviewed Original ResearchConceptsOffspring systolic blood pressureSystolic blood pressureIntrauterine growth restrictionPregnancy weight gainBlood pressureYears of ageMaternal smokingPrenatal factorsChildhood growthPrepregnancy BMIBMI trajectoriesChildhood systolic blood pressureChildren's systolic blood pressureMaternal pregnancy weight gainWeight gainChildhood BMI trajectoriesHeavy maternal smokingOffspring blood pressureChildhood blood pressureMother-child pairsCollaborative Perinatal ProjectChronic hypertensionObstetric formPreeclampsia-eclampsiaChildhood BMIAssociation of maternal anemia with increased wheeze and asthma in children
Triche EW, Lundsberg LS, Wickner PG, Belanger K, Leaderer BP, Bracken MB. Association of maternal anemia with increased wheeze and asthma in children. Annals Of Allergy Asthma & Immunology 2011, 106: 131-139.e1. PMID: 21277514, PMCID: PMC3073499, DOI: 10.1016/j.anai.2010.11.007.Peer-Reviewed Original ResearchConceptsMaternal anemiaEarly-onset transientRespiratory health outcomesChildren of womenOffspring of mothersRespiratory disease developmentChildren of mothersYears of ageEarly childhoodAge 3Delivery hospitalizationsRecurrent wheezeCurrent asthmaAsthma diagnosisChildhood asthmaInfant wheezeMaternal nutritionRespiratory healthWheezeAsthmaAnemiaHealth outcomesPregnancyAnemia diagnosisMicronutrient status
2010
Association Between Placental Morphology and Childhood Systolic Blood Pressure
Wen X, Triche E, Hogan J, Shenassa E, Buka S. Association Between Placental Morphology and Childhood Systolic Blood Pressure. Hypertension 2010, 57: 48-55. PMID: 21079045, PMCID: PMC3074204, DOI: 10.1161/hypertensionaha.110.162792.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureChildhood systolic blood pressureShort-term blood pressureHigher systolic blood pressureLong-term blood pressureLarger placental sizeFull-term singletonsCollaborative Perinatal ProjectDecidual vesselsPlacental inefficiencyPlacental thicknessPregnancy courseVascular resistancePlacental weightPlacental volumePlacental sizeVascular lesionsCord vesselsPlacental morphologyPerinatal ProjectAuscultation methodLesionsAssociationVesselsPDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original ResearchMorbidity and Mortality among Infants Born to HIV-Infected Women in South Africa: Implications for Child Health in Resource-Limited Settings
Venkatesh K, de Bruyn G, Marinda E, Otwombe K, van Niekerk R, Urban M, Triche E, McGarvey S, Lurie M, Gray G. Morbidity and Mortality among Infants Born to HIV-Infected Women in South Africa: Implications for Child Health in Resource-Limited Settings. Journal Of Tropical Pediatrics 2010, 57: 109-119. PMID: 20601692, PMCID: PMC3107462, DOI: 10.1093/tropej/fmq061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBreast FeedingChildChild WelfareFemaleFollow-Up StudiesHIV InfectionsHIV-1HospitalizationHumansIncidenceInfantInfectious Disease Transmission, VerticalKaplan-Meier EstimateMaternal AgeMorbidityPregnancyPregnancy Complications, InfectiousProportional Hazards ModelsProspective StudiesSouth AfricaViral LoadYoung AdultConceptsPlasma viral loadMaternal plasma viral loadInfant HIV infectionHIV infectionInfant morbidityChild healthMultivariable Cox proportional hazards modelsCox proportional hazards modelInfant feeding statusPediatric HIV infectionProspective cohort studyRisk of morbidityInfant health outcomesMonths of lifeProportional hazards modelResource limited settingsAntiretroviral prophylaxisMaternal viremiaCohort studyRespiratory infectionsViral loadMaternal ageMorbidityHazards modelHealth outcomes
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalenceAssociation of pediatric asthma severity with exposure to common household dust allergens
Gent JF, Belanger K, Triche EW, Bracken MB, Beckett WS, Leaderer BP. Association of pediatric asthma severity with exposure to common household dust allergens. Environmental Research 2009, 109: 768-774. PMID: 19473655, PMCID: PMC2706291, DOI: 10.1016/j.envres.2009.04.010.Peer-Reviewed Original ResearchConceptsAsthma severityDer p 1Asthmatic childrenMedication usePet allergensDust allergensDisease severityNon-atopic asthmatic childrenHouse dust mite allergen concentrationsGreater asthma severityPediatric asthma severityPet allergen levelsIndependent risk factorMonthly telephone interviewsDust mite allergen concentrationsDose-response relationshipMite allergen concentrationsAllergic statusIgE statusInhalant allergensIgE sensitivityDaily symptomsDust miteRisk factorsSymptom frequencySymptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
2007
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Medical Genomics 2007, 8: 15. PMID: 17407567, PMCID: PMC1852548, DOI: 10.1186/1471-2350-8-15.Peer-Reviewed Original ResearchConceptsPersistent coughSurfactant protein ARespiratory symptomsWhite infantsClinician-diagnosed asthmaInfant respiratory symptomsRespiratory symptom frequencyRisk of wheezeCohort of infantsSingle nucleotide polymorphismsMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityStudy infantsNewborn infantsSymptom frequencyInfant's birthStandardized questionnaireCoughWheezeAsthmaInfantsTelephone interviewsOlder children
2005
Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma
Belanger K, Gent JF, Triche EW, Bracken MB, Leaderer BP. Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma. American Journal Of Respiratory And Critical Care Medicine 2005, 173: 297-303. PMID: 16254270, PMCID: PMC2662932, DOI: 10.1164/rccm.200408-1123oc.Peer-Reviewed Original ResearchConceptsRespiratory symptomsChest tightnessIndoor nitrogen dioxide exposureDays of wheezeIndoor NO2 exposureLikelihood of wheezeMold/mildewShortness of breathAdverse respiratory effectsNitrogen dioxide exposurePublic health concernAsthma symptomsActive asthmaMaintenance medicationRespiratory effectsAsthmaChronic exposureSymptomsWheezeHealth concernHome interviewsNO2 exposureMedicationsChildrenGas stoves
2004
Prediction of residential pet and cockroach allergen levels using questionnaire information.
Gehring U, Triche E, van Strien RT, Belanger K, Holford T, Gold DR, Jankun T, Ren P, McSharry JE, Beckett WS, Platts-Mills TA, Chapman MD, Bracken MB, Leaderer BP. Prediction of residential pet and cockroach allergen levels using questionnaire information. Environmental Health Perspectives 2004, 112: 834-839. PMID: 15175169, PMCID: PMC1242009, DOI: 10.1289/ehp.6685.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollution, IndoorAllergensAnimalsAnimals, DomesticCatsChildChild, PreschoolCockroachesDogsDustEnvironmental ExposureEnzyme-Linked Immunosorbent AssayFemaleForecastingHumansInfant WelfareInfant, NewbornOwnershipPregnancyReproducibility of ResultsSensitivity and SpecificitySurveys and QuestionnairesConceptsPresence of cockroachesEnzyme-linked immunosorbent assayAllergen levelsCut pointsDog ownershipLower cut pointQuestionnaire informationHouse dustConcentration of allergenPet ownershipPast pet ownershipAllergen exposureCockroach allergensAllergen concentrationsMain living areaEpidemiologic purposesImmunosorbent assayAllergen contentCatsExposure assessmentMeans of questionnairesAllergensDust samplesInfant beddingQuestionnaire reports
2003
Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma
Gent JF, Triche EW, Holford TR, Belanger K, Bracken MB, Beckett WS, Leaderer BP. Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma. JAMA 2003, 290: 1859-1867. PMID: 14532314, DOI: 10.1001/jama.290.14.1859.Peer-Reviewed Original ResearchConceptsRescue medication useRespiratory symptomsDaily respiratory symptomsMedication useMaintenance medicationLikelihood of wheezeShortness of breathLogistic regression analysisRescue medicationChest tightnessActive asthmaAsthmatic childrenMedication usersRisk factorsAsthmaMedicationsSymptomsMean levelsSubject's motherChildrenRegression analysisAssociationExposureMothersHigh levels
2002
Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density.
Leaderer BP, Belanger K, Triche E, Holford T, Gold DR, Kim Y, Jankun T, Ren P, McSharry Je JE, Platts-Mills TA, Chapman MD, Bracken MB. Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. Environmental Health Perspectives 2002, 110: 419-425. PMID: 11940461, PMCID: PMC1240806, DOI: 10.1289/ehp.02110419.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAir Pollution, IndoorAllergensAnimalsAsthmaCatsChildChild, PreschoolCockroachesCohort StudiesConnecticutDogsEducational StatusEnvironmental MonitoringEnzyme-Linked Immunosorbent AssayEpidemiological MonitoringEthnicityFemaleHousingHumansMaleMassachusettsMitesPopulation DensityPovertyRisk AssessmentUrban PopulationConceptsExacerbation of asthmaDog allergensDust miteCockroach allergensLower cut pointCut pointsMore allergensLongitudinal birth cohort studyOngoing longitudinal birth cohort studyBirth cohort studyMultiple logistic regressionSocioeconomic factorsAllergic sensitizationCohort studyAsthmatic childrenAllergen burdenIndividual allergensAsthmatic homesHome exposureAllergen concentrationsHigher household incomeAllergensLogistic regressionMain living areaHome concentrations