2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activityPhysical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study
Spracklen C, Ryckman K, Triche E, Saftlas A. Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study. Maternal And Child Health Journal 2016, 20: 1193-1202. PMID: 26910608, PMCID: PMC5538351, DOI: 10.1007/s10995-016-1919-y.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaLeisure-time PAGestational hypertensionSedentary activitiesMedical chart reviewCase-control studyGestational hypertensiveObjectivePhysical activityPreeclampsia resultsPregnancy hypertensionPrepregnancy BMINormotensive womenChart reviewHypertension riskPreeclampsia riskSubsequent riskPreeclampsiaEpidemiologic studiesPA exposurePhysical activityMultinomial logistic regressionHypertensionControl studyDisease statusBirth records
2013
Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
Saftlas A, Rubenstein L, Prater K, Harland K, Field E, Triche E. Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal Of Reproductive Immunology 2013, 101: 104-110. PMID: 24011785, DOI: 10.1016/j.jri.2013.07.006.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaVaginal exposureNulliparous womenImmune maladaptation hypothesisOdds of preeclampsiaMedical chart reviewPercentile of exposureBarrier contraceptive methodsCase-control studyVaginal sexual intercourseAllogeneic fetusChart reviewIowa womenPaternal HLAAntigen exposureImmune toleranceNormotensive controlsPaternal antigensMaternal tolerancePreeclampsia casesPreeclampsia riskSubsequent riskSeminal fluidLive birthsContraceptive use