2011
Association of variants in innate immune genes with asthma and eczema
Sharma S, Poon A, Himes BE, Lasky‐Su J, Sordillo JE, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Association of variants in innate immune genes with asthma and eczema. Pediatric Allergy And Immunology 2011, 23: 315-323. PMID: 22192168, PMCID: PMC3412627, DOI: 10.1111/j.1399-3038.2011.01243.x.Peer-Reviewed Original ResearchConceptsInnate immune genesPathogenesis of asthmaInnate immune pathwaysSingle nucleotide polymorphismsAsthma StudyImmune genesImmune pathwaysChildhood Asthma StudyPolymorphisms of genesAssociation of variantsChildhood asthmaEczema riskAsthmaCase controlEczemaImmune variantsAdditional single nucleotide polymorphismsBayesian network analysisHome allergensScreening algorithmDifferent genetic determinantsTop single nucleotide polymorphismsPathogenesisMultiple comparisonsDisease susceptibilityEffects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1
Sordillo JE, Sharma S, Poon A, Lasky-Su J, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1. BMC Medical Genomics 2011, 12: 158. PMID: 22151743, PMCID: PMC3252252, DOI: 10.1186/1471-2350-12-158.Peer-Reviewed Original ResearchConceptsEndotoxin exposureAsthma riskProtective effectRisk of asthmaGenetic polymorphismsChildhood asthma riskChildhood Asthma StudyInnate immune pathwaysInnate immunity pathwaysAsthma StudyAsthmaConclusionOur findingsImmune pathwaysMinor alleleHome allergensImmunity pathwaysEczemaMajor alleleChildrenEndotoxinExposureRiskSignificant interactionPolymorphismACAA1Association of maternal anemia with increased wheeze and asthma in children
Triche EW, Lundsberg LS, Wickner PG, Belanger K, Leaderer BP, Bracken MB. Association of maternal anemia with increased wheeze and asthma in children. Annals Of Allergy Asthma & Immunology 2011, 106: 131-139.e1. PMID: 21277514, PMCID: PMC3073499, DOI: 10.1016/j.anai.2010.11.007.Peer-Reviewed Original ResearchConceptsMaternal anemiaEarly-onset transientRespiratory health outcomesChildren of womenOffspring of mothersRespiratory disease developmentChildren of mothersYears of ageEarly childhoodAge 3Delivery hospitalizationsRecurrent wheezeCurrent asthmaAsthma diagnosisChildhood asthmaInfant wheezeMaternal nutritionRespiratory healthWheezeAsthmaAnemiaHealth outcomesPregnancyAnemia diagnosisMicronutrient status
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalenceSymptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
2008
Indoor Combustion and Asthma
Belanger K, Triche E. Indoor Combustion and Asthma. Immunology And Allergy Clinics Of North America 2008, 28: 507-519. PMID: 18572104, PMCID: PMC2760246, DOI: 10.1016/j.iac.2008.03.011.Peer-Reviewed Original Research
2007
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Medical Genomics 2007, 8: 15. PMID: 17407567, PMCID: PMC1852548, DOI: 10.1186/1471-2350-8-15.Peer-Reviewed Original ResearchConceptsPersistent coughSurfactant protein ARespiratory symptomsWhite infantsClinician-diagnosed asthmaInfant respiratory symptomsRespiratory symptom frequencyRisk of wheezeCohort of infantsSingle nucleotide polymorphismsMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityStudy infantsNewborn infantsSymptom frequencyInfant's birthStandardized questionnaireCoughWheezeAsthmaInfantsTelephone interviewsOlder children
2006
Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma. BMC Medical Genomics 2006, 7: 68. PMID: 16884531, PMCID: PMC1557482, DOI: 10.1186/1471-2350-7-68.Peer-Reviewed Original ResearchConceptsOtitis mediaWhite infantsInfant respiratory symptomsPhysician-diagnosed asthmaCohort of infantsLarger confirmatory studiesSurfactant proteinsInnate immune responseMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityRespiratory symptomsCommon infectionsProspective studyImmune responseStudy populationInfant's birthStandardized questionnaireInfantsConclusionThese resultsAsthmaTelephone interviewsConfirmatory studiesWhole bloodThe Epidemiology of Asthma During Pregnancy: Prevalence, Diagnosis, and Symptoms
Kwon HL, Triche EW, Belanger K, Bracken MB. The Epidemiology of Asthma During Pregnancy: Prevalence, Diagnosis, and Symptoms. Immunology And Allergy Clinics Of North America 2006, 26: 29-62. PMID: 16443142, DOI: 10.1016/j.iac.2005.11.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPregnant womenLarge prospective cohort studyEpidemiology of asthmaProspective cohort studySelf-reported asthmaPopulation-level improvementsAsthma controlCohort studyAsthma diagnosisAsthma attacksCommon conditionPrevalence ratesClinical involvementAsthmaNational dataPregnancyPrevalenceDiagnosisWomenUnited StatesPopulation characteristicsRepresentative dataPrevious yearFurther researchFurther characterization
2005
Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma
Belanger K, Gent JF, Triche EW, Bracken MB, Leaderer BP. Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma. American Journal Of Respiratory And Critical Care Medicine 2005, 173: 297-303. PMID: 16254270, PMCID: PMC2662932, DOI: 10.1164/rccm.200408-1123oc.Peer-Reviewed Original ResearchConceptsRespiratory symptomsChest tightnessIndoor nitrogen dioxide exposureDays of wheezeIndoor NO2 exposureLikelihood of wheezeMold/mildewShortness of breathAdverse respiratory effectsNitrogen dioxide exposurePublic health concernAsthma symptomsActive asthmaMaintenance medicationRespiratory effectsAsthmaChronic exposureSymptomsWheezeHealth concernHome interviewsNO2 exposureMedicationsChildrenGas stoves
2004
Association of early‐onset otitis media in infants and exposure to household mould
Pettigrew MM, Gent JF, Triche EW, Belanger KD, Bracken MB, Leaderer BP. Association of early‐onset otitis media in infants and exposure to household mould. Paediatric And Perinatal Epidemiology 2004, 18: 441-447. PMID: 15535820, DOI: 10.1111/j.1365-3016.2004.00596.x.Peer-Reviewed Original ResearchConceptsEarly otitis mediaOtitis mediaMonths of ageHousehold moldInfant respiratory symptomsAcute otitis mediaPhysician-diagnosed asthmaCohort of infantsOtitis media episodesRecurrent otitis mediaEarly onset otitis mediaMonths of lifeQuarterly telephone interviewsRespiratory symptomsCommon infectionsProspective studyPotential confoundersHigh riskInfant's birthStandardised questionnaireTelephone interviewsMonthsAsthmaEarly childhoodFurther studiesExposure to NO2 and Nitrous Acid and Respiratory Symptoms in the First Year of Life
van Strien RT, Gent JF, Belanger K, Triche E, Bracken MB, Leaderer BP. Exposure to NO2 and Nitrous Acid and Respiratory Symptoms in the First Year of Life. Epidemiology 2004, 15: 471-478. PMID: 15232409, DOI: 10.1097/01.ede.0000129511.61698.d8.Peer-Reviewed Original Research
2003
Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma
Gent JF, Triche EW, Holford TR, Belanger K, Bracken MB, Beckett WS, Leaderer BP. Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma. JAMA 2003, 290: 1859-1867. PMID: 14532314, DOI: 10.1001/jama.290.14.1859.Peer-Reviewed Original ResearchConceptsRescue medication useRespiratory symptomsDaily respiratory symptomsMedication useMaintenance medicationLikelihood of wheezeShortness of breathLogistic regression analysisRescue medicationChest tightnessActive asthmaAsthmatic childrenMedication usersRisk factorsAsthmaMedicationsSymptomsMean levelsSubject's motherChildrenRegression analysisAssociationExposureMothersHigh levelsAsthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies
Bracken M, Triche E, Belanger K, Saftlas A, Beckett W, Leaderer B. Asthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies. Obstetrics And Gynecology 2003, 102: 739. DOI: 10.1097/00006250-200310000-00016.Peer-Reviewed Original ResearchAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaPregnant patientsAsthma therapySymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionΒ2 agonistsAsthmaSymptomsMedicationsAsthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
Bracken MB, Triche EW, Belanger K, Saftlas A, Beckett WS, Leaderer BP. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstetrics And Gynecology 2003, 102: 739-52. PMID: 14551004, DOI: 10.1016/s0029-7844(03)00621-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Asthmatic AgentsAnti-Inflammatory AgentsAsthmaBirth WeightCase-Control StudiesConnecticutFemaleFetal Growth RetardationFetal Membranes, Premature RuptureHumansInfant, Low Birth WeightInfant, NewbornMassachusettsPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsSeverity of Illness IndexSteroidsTheophyllineConceptsAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaAsthma therapyPregnant patientsSymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionAsthmaSymptomsMedicationsDiagnosisSymptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma
Belanger K, Beckett W, Triche E, Bracken MB, Holford T, Ren P, McSharry JE, Gold DR, Platts-Mills TA, Leaderer BP. Symptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma. American Journal Of Epidemiology 2003, 158: 195-202. PMID: 12882940, DOI: 10.1093/aje/kwg148.Peer-Reviewed Original ResearchConceptsInfants of mothersSymptoms of wheezePersistent coughPhysician-diagnosed asthmaDust mite allergenRelation of exposureFirst yearAsthma historyDog allergensIndoor allergensInfant wheezeMaternal historyMite allergensCoughWheezeHome exposureAsthmaInfantsAllergensSymptomsAsthmatic siblingsMothersExposureRiskFirst study
2002
Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma.
Gent JF, Ren P, Belanger K, Triche E, Bracken MB, Holford TR, Leaderer BP. Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environmental Health Perspectives 2002, 110: a781-a786. PMID: 12460818, PMCID: PMC1241132, DOI: 10.1289/ehp.021100781.Peer-Reviewed Original ResearchConceptsPersistent coughRespiratory symptomsDays of wheezeHigh-risk groupFirst yearPotential confounding factorsPoisson regression analysisCFU/m3Infant's first yearMaternal allergyMaternal historyHigh riskCoughWheezeAsthmaParticular fungal genusHousehold moldConfounding factorsInfant's lifeColony-forming unitsSignificant riskSocioeconomic statusCertain housing characteristicsHigh levelsSusceptible population
2001
Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Children
von Maffei J, Beckett W, Belanger K, Triche E, Zhang H, Machung J, Leaderer B. Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Children. Journal Of Asthma 2001, 38: 555-564. PMID: 11714078, DOI: 10.1081/jas-100107120.Peer-Reviewed Original ResearchConceptsRisk factorsUrban residenceAfrican American childrenMaternal cigarette smokingPhysician-diagnosed asthmaMultiple risk factorsYears of ageMaternal asthmaAsthmatic childrenAsthma prevalenceCigarette smokingAsthmaAmerican childrenAfrican American mothersIdentifiable factorsChildrenAmerican mothersResidenceFactorsSmokingAllergyNewbornsPrevalence