2019
Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior
Tang L, Higley MJ. Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior. Neuron 2019, 105: 346-354.e5. PMID: 31757603, PMCID: PMC6981039, DOI: 10.1016/j.neuron.2019.10.014.Peer-Reviewed Original ResearchConceptsPyramidal neuronsNeocortical sensory areasPrimary visual cortexDistinct brain areasEyeblink conditioning taskCorticopontine neuronsAxonal projectionsBrain areasCortical subnetworksVisual cortexCalcium imagingVisuomotor behaviorSensory areasOptogenetic manipulationNeuronsConditioning taskDistinct targetsCortexMiceSimultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates
2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic