2004
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
Caldarone BJ, Harrist A, Cleary MA, Beech RD, King SL, Picciotto MR. High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biological Psychiatry 2004, 56: 657-664. PMID: 15522249, DOI: 10.1016/j.biopsych.2004.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnalysis of VarianceAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBromodeoxyuridineCell CountCell ProliferationDose-Response Relationship, DrugDrosophila ProteinsDrug InteractionsHelplessness, LearnedHindlimb SuspensionHippocampusImmunohistochemistryMecamylamineMiceMice, Inbred C57BLMice, KnockoutNeuronsNicotinic AntagonistsNortriptylineReceptors, NicotinicSwimmingConceptsHigh-affinity nAChRsHippocampal cell proliferationNicotinic acetylcholine receptorsSwim testAcetylcholine receptorsCell proliferationHigh-affinity nicotinic acetylcholine receptorsNoncompetitive nAChR antagonist mecamylamineAntagonism of nAChRsAntidepressant-induced increasesAntidepressant-like effectsNAChR antagonist mecamylamineWild-type miceInhibition of nAChRsAntidepressants actAntidepressant actionAntidepressant effectsChronic treatmentAntagonist mecamylamineAntidepressant propertiesTricyclic antidepressantsAntidepressant activityTherapeutic effectKnockout miceNoncompetitive antagonist
2003
Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice
Caldarone BJ, Karthigeyan K, Harrist A, Hunsberger JG, Wittmack E, King SL, Jatlow P, Picciotto MR. Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice. Psychopharmacology 2003, 170: 94-101. PMID: 12879206, DOI: 10.1007/s00213-003-1518-7.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsTail suspension testDuration of treatmentAntidepressant amitriptylineTransgenic miceChronic treatmentImmobility timeB6 miceDepression modelChronic AMI treatmentFemale B6 miceTricyclic antidepressant amitriptylineMechanism of actionAMI administrationOral amitriptylineAntidepressant treatmentControl miceLH paradigmSwim testFemale miceOral administrationAMI treatmentEscape latencySuspension testAnimal models
2000
Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background
Caldarone B, George T, Zachariou V, Picciotto M. Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background. Pharmacology Biochemistry And Behavior 2000, 66: 811-817. PMID: 10973520, DOI: 10.1016/s0091-3057(00)00271-9.Peer-Reviewed Original ResearchConceptsEscape latencyInescapable shockHelplessness behaviorGenetic backgroundInescapable shock pretreatmentControl miceMale C57BL/6JMixed genetic backgroundB6 xGender differencesNonshocked controlsB6 femalesMiceB6 malesEscape performanceCommon genetic backgroundKnockout modelsHelplessness modelShock pretreatmentMalesFemalesLatencyPain