Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions
Brabant C, Alleva L, Grisar T, Quertemont E, Lakaye B, Ohtsu H, Lin JS, Jatlow P, Picciotto MR, Tirelli E. Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Psychopharmacology 2008, 202: 673-687. PMID: 18843481, DOI: 10.1007/s00213-008-1345-y.Peer-Reviewed Original ResearchConceptsEffects of thioperamideCocaine-induced hyperlocomotionCocaine-induced locomotionLocomotor effectsHistaminergic systemKnockout micePotential drug-drug interactionsContribution of histamineNon-histaminergic neuronsPlasma cocaine concentrationsPotential pharmacokinetic interactionsCocaine-induced hyperactivityCocaine plasma concentrationsDrug-drug interactionsReceptor inverse agonistInverse agonist thioperamideSelective H3 agonistH3 receptor inverse agonistConclusionsThe present resultsH3 autoreceptorsPharmacokinetic interactionsIntraperitoneal injectionAgonist AHistamine releasePharmacokinetic effects