Promoter elements conferring neuron-specific expression of the β2-subunit of the neuronal nicotinic acetylcholine receptor studiedin vitro and in transgenic mice
Bessis A, Salmon A, Zoli M, Le Novère N, Picciotto M, Changeux J. Promoter elements conferring neuron-specific expression of the β2-subunit of the neuronal nicotinic acetylcholine receptor studiedin vitro and in transgenic mice. Neuroscience 1995, 69: 807-819. PMID: 8596650, DOI: 10.1016/0306-4522(95)00303-z.Peer-Reviewed Original ResearchConceptsSpatio-temporal expression patternsFunctional E-boxesCell-specific transcriptionNeuron-specific transcriptionSite-directed mutagenesisTransient transfection assaysNeuron-specific expressionNeuronal genesRE1 sequenceTranscribed regionDeletion analysisE-boxRegulatory elementsPromoter elementsUpstream sequencesTransgenic miceTransfection assaysReporter geneRepressor elementExpression patternsNeuronal nicotinic acetylcholine receptorsGenesNicotinic acetylcholine receptorsRegulatory propertiesTranscription