2006
Guidelines on nicotine dose selection for in vivo research
Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology 2006, 190: 269-319. PMID: 16896961, DOI: 10.1007/s00213-006-0441-0.Peer-Reviewed Original ResearchConceptsRoute of administrationDose selectionAnimal modelsDose rangeNicotine replacement therapyChronic nicotine exposureDose-response relationshipDrug-taking behaviorTobacco exposureNicotine exposureCigarette smokingReplacement therapyVivo effectsChronic exposureNicotine metabolismVivo responseNonhuman primatesVivo studiesObjectivesThis reviewRegimenVivo researchAdministrationExposureGenetic backgroundReview
2005
β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology 2005, 184: 328-338. PMID: 16133126, DOI: 10.1007/s00213-005-0099-z.Peer-Reviewed Original ResearchConceptsNicotine exposureNicotinic acetylcholine receptorsFood-reinforced respondingAcetylcholine receptorsPrior nicotine exposureNicotine-induced increasesProgressive ratioNicotinic receptor subtypesEffects of nicotineWild-type miceProgressive ratio testC57BL/6 miceReceptor subtypesConclusionThese dataChronic exposureReinforcement testingMiceΒ2 subunitUnpaired presentationsExposureReceptorsApproach trainingPresentationPaired presentationsPrimary reinforcement
2003
In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice
Brunzell DH, Russell DS, Picciotto MR. In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice. Journal Of Neurochemistry 2003, 84: 1431-1441. PMID: 12614343, DOI: 10.1046/j.1471-4159.2003.01640.x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAmygdalaAnimalsCotinineCyclic AMP Response Element-Binding ProteinDrug Administration ScheduleLimbic SystemMaleMesencephalonMiceMice, Inbred C57BLMitogen-Activated Protein KinasesNicotineNicotinic AgonistsNucleus AccumbensPhosphorylationPrefrontal CortexSignal TransductionTobacco Use DisorderVentral Tegmental AreaConceptsCAMP response element-binding proteinChronic nicotine exposureChronic nicotineNicotine exposurePrefrontal cortexC57BL/6J miceTyrosine hydroxylaseNicotine dependenceCREB phosphorylationVentral tegmental areaCREB activityResponse element-binding proteinCatecholaminergic toneNicotine treatmentNicotine withdrawalNicotine reinforcementTegmental areaNucleus accumbensNeuronal plasticityElement-binding proteinDrug reinforcementChronic exposureTH levelsNeural plasticityWestern blotting
1999
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, Nestler E. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-276. PMID: 10499584, DOI: 10.1038/45790.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlutamate receptor subunit GluR2Locomotor-activating effectsFos family transcription factorsTranscription factor ΔFosBDrugs of abuseΔFosB expressionAcute exposureTransgenic miceChronic exposureSubunit GluR2ΔFosBCocaine addictionAccumbensCocainePersistent expressionTranscription factorsSustained accumulationBrainExposureStable isoformSubset of nucleiExpressionGene expressionMorphine