2012
Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion
Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR. Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion. Behavioural Brain Research 2012, 231: 170-180. PMID: 22433585, PMCID: PMC3334440, DOI: 10.1016/j.bbr.2012.03.002.Peer-Reviewed Original ResearchConceptsAuditory stimulus processingStimulus processingAuditory discrimination learningUnderlying neurobiological mechanismsAuditory discrimination paradigmLow rates (DRL) taskPerinatal nicotine exposureAuditory discriminationGeneral deficitDiscrimination learningTask performanceNicotine exposureDiscrimination impairmentNeurobiological mechanismsMouse perinatal developmentDiscrimination paradigmRate taskDifferential reinforcementAdministration of nicotineTaskAuditory pathwayLearningNicotinic acetylcholine receptorsMaternal smokingProcessing
2010
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology 2010, 14: 389-398. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/s1461145710001227.Peer-Reviewed Original ResearchConceptsNicotine inhalerWithdrawal symptomsReceptor occupancyTobacco smokingLow nicotine cigarettesAdministration of nicotineHigh receptor occupancyDoses of nicotineNicotinic acetylcholine receptorsInhaler useTobacco smokersBaseline scanRegular cigarettesInhalerConstant infusionAcetylcholine receptorsSPECT studiesCigarettesSymptomsBeta 2Significant decreaseNicotineSignificant differencesSmokingNAChRs