Sisi Zheng
About
Research
Publications
2024
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling
Hu Z, Chen P, Li W, Krone M, Zheng S, Saarbach J, Velasco I, Hines J, Liu Y, Crews C. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science Advances 2024, 10: eadj7251. PMID: 38536914, PMCID: PMC10971414, DOI: 10.1126/sciadv.adj7251.Peer-Reviewed Original ResearchConceptsInhibit cancer cell viabilityProteome-wide levelCancer cell viabilityDifferential signaling pathwaysPhosphoproteomic approachTyrosine dephosphorylationProtein dephosphorylationSignal transductionActivating dephosphorylationInduce apoptosisReceptor tyrosine kinase inhibitorsRTK activationSignaling pathwayInhibition of kinasesDephosphorylationEpidermal growth factor receptorGrowth factor receptorCell viabilityFactor receptorInhibitory approachesTyrosineTyrosine kinase inhibitorsInhibitory effectInhibitory potentialKinase inhibitors
2023
Utility of Hook Sign in the Diagnosis of Median Arcuate Ligament Syndrome
Chan S, Weininger G, Kozhimala M, Sumpio B, Levine L, Harris S, Zheng S, Ochoa Chaar C, Guzman R, Sumpio B. Utility of Hook Sign in the Diagnosis of Median Arcuate Ligament Syndrome. Annals Of Vascular Surgery 2023, 94: 165-171. PMID: 37023920, DOI: 10.1016/j.avsg.2023.03.018.Peer-Reviewed Original ResearchConceptsMedian arcuate ligament syndromeBody mass indexCeliac artery compressionArcuate ligament syndromeCeliac arteryInstitutional review board-approved retrospective chart reviewDiagnosis of MALSElectronic medical record reviewMedian arcuate ligamentNonspecific abdominal painRetrospective chart reviewMedical record reviewTertiary academic centerSignificant predictorsHook signWilcoxon rank sum testRank sum testMALS patientsAbdominal painTomography angiography imagesArtery compressionChart reviewPatient demographicsArcuate ligamentRadiologic characteristics
2022
Prevalence and Characteristics of Patients with Median Arcuate Ligament Syndrome in a Cohort Diagnosed with Celiac Artery Compression.
Kozhimala M, Chan S, Weininger G, Sumpio B, Levine L, Harris S, Zheng S, Longo W, Ochoa Chaar C, Guzman R, Sumpio B. Prevalence and Characteristics of Patients with Median Arcuate Ligament Syndrome in a Cohort Diagnosed with Celiac Artery Compression. Journal Of The American College Of Surgeons 2022, 236: 1085-1091. PMID: 36476640, DOI: 10.1097/xcs.0000000000000500.Peer-Reviewed Original ResearchConceptsMedian arcuate ligament syndromeCeliac artery compressionArcuate ligament syndromeCharacteristics of patientsMALS patientsArtery compressionArtery diseaseRenal diseaseMesenteric artery diseasePeripheral arterial diseasePeripheral artery diseaseRetrospective chart reviewCohort of patientsMedical record reviewFrequent differential diagnosisSignificant differencesAbdominal symptomsAtherosclerotic characteristicsEpigastric painGastrointestinal comorbiditiesChart reviewArterial diseaseAtherosclerotic diseaseRecord reviewClinical symptomsThe Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review
Hanchuk S, Casilla-Lennon M, Zheng S, Kim DD, Press B, Nguyen JV, Grimshaw A, Leapman MS, Rickey LM, Cavallo JA. The Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review. Academic Medicine 2022, 97: 1071-1078. PMID: 35171119, PMCID: PMC9247020, DOI: 10.1097/acm.0000000000004629.Peer-Reviewed Original ResearchConceptsPhysician pregnancyMulti-institutional prospective observational studyDefinitive evidence-based recommendationsMaternal-fetal health outcomesProspective observational studyImpact of pregnancyEvidence-based recommendationsFull-text reviewOvid EmbaseCochrane LibraryPhysician specialtyObservational studyOvid MEDLINEInclusion criteriaStudy populationPregnancyHealth outcomesPhysiciansCommunity studySurgical specialtiesGoogle ScholarWork productivityWomen physiciansScoping ReviewPublication year
2021
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)
Chen PH, Hu Z, An E, Okeke I, Zheng S, Luo X, Gong A, Jaime-Figueroa S, Crews CM. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS Chemical Biology 2021, 16: 2808-2815. PMID: 34780684, PMCID: PMC10437008, DOI: 10.1021/acschembio.1c00693.Peer-Reviewed Original ResearchConceptsSer/Thr phosphataseChemical biology approachPP2A holoenzymeProtein dephosphorylationBiology approachProtein substratesTranscriptional activationProtein phosphorylationCatalytic subunitCell biologyReporter geneProtein activityRetinoblastoma proteinOff-target effectsCritical proteinsDephosphorylationTernary complexPhosphorylationKinase inhibitorsFOXO3aPROTACsProteinChimerasPhosphataseDrug resistancePregnancy in physicians: A scoping review
Casilla-Lennon M, Hanchuk S, Zheng S, Kim DD, Press B, Nguyen JV, Grimshaw A, Leapman MS, Cavallo JA. Pregnancy in physicians: A scoping review. The American Journal Of Surgery 2021, 223: 36-46. PMID: 34315575, PMCID: PMC8688196, DOI: 10.1016/j.amjsurg.2021.07.011.Peer-Reviewed Original ResearchConceptsPhysician pregnancyFetal complication ratesComplication ratePregnancy eventsFetal healthObservational studyEvidence levelPregnancyOccupational hazard risksFertility treatmentWork productivityComprehensive scoping reviewFurther studiesScoping ReviewHigh ratePersonal healthPersistent stigmatizationHealthReviewComprehensive literature reviewLiterature reviewProfessional impactPhysiciansTemplate analysisWomenElectrophilic Screening Platforms for Identifying Novel Covalent Ligands for E3 Ligases
Zheng S, Crews CM. Electrophilic Screening Platforms for Identifying Novel Covalent Ligands for E3 Ligases. Biochemistry 2021, 60: 2367-2370. PMID: 34152723, DOI: 10.1021/acs.biochem.1c00301.Peer-Reviewed Original Research
2020
Allostery and Conformational Dynamics in Tyrosine Kinase Regulation
Marsiglia W, Katigbak J, Zheng S, Mohammadi M, Zhang Y, Traaseth N. Allostery and Conformational Dynamics in Tyrosine Kinase Regulation. Biophysical Journal 2020, 118: 522a. DOI: 10.1016/j.bpj.2019.11.2872.Peer-Reviewed Original Research
2019
A Conserved Allosteric Pathway in Tyrosine Kinase Regulation
Marsiglia WM, Katigbak J, Zheng S, Mohammadi M, Zhang Y, Traaseth NJ. A Conserved Allosteric Pathway in Tyrosine Kinase Regulation. Structure 2019, 27: 1308-1315.e3. PMID: 31204250, PMCID: PMC6687525, DOI: 10.1016/j.str.2019.05.002.Peer-Reviewed Original ResearchConceptsTyrosine kinaseTyrosine kinase regulationAllosteric control mechanismReceptor tyrosine kinasesTyrosine kinase familyKinase regulationDFG motifActivation loopAllosteric pathwayKinase familyMutational disruptionKinase hingeInactive conformationHydrophobic residuesHuman diseasesKinaseConformational perturbationsCombination of NMREnzyme thermostabilityMutationsSkeletal syndromeActive siteMolecular dynamics simulationsThermostabilityStructural analysis