Valentyna Kostiuk
Postgraduate AssociateAbout
Research
Publications
2025
CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis
Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseCACNA1GLow-voltage-activated calcium channelsExpression of Cacna1gCalcium channelsPatient cohortCardiac functionLR patterningHeterotaxyLR organizerChannel familyCACNA1SHeart diseaseLeft-rightG expressionXenopus tropicalisAbnormal expressionProcess of cilia formationCardiac loopingMultiple organsSignaling cascadesLR asymmetryPatientsT-typeEmbryonic developmentNup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427
Kostiuk V, Kabir R, Levangie K, Empke S, Morgan K, Owens N, Lusk C, Khokha M. Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427. Development 2025, 152: dev202865. PMID: 39791357, PMCID: PMC11829755, DOI: 10.1242/dev.202865.Peer-Reviewed Original ResearchConceptsMaternal transcriptsMaternal-to-zygotic transitionMaternal RNA clearanceZinc-finger transcription factorDegradation of maternal transcriptsEctodermal cell fatesMaternal-zygotic transitionNuclear pore complexNucleoporin functionZygotic transcriptionNuclear exportTranscript stabilityCell fateNuclear retentionTranscription factorsPore complexNup107TranscriptionEarly embryosRecognition sitesRNA clearanceGastrulationGerm layersTime course
2024
Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions.
Kostiuk V, Fereydooni S, Setia O, Loh S, Strosberg D, Tonnessen B, Ochoa Chaar C, Aboian E. Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions. Vascular 2024, 17085381241296606. PMID: 39460535, DOI: 10.1177/17085381241296606.Peer-Reviewed Original ResearchGroin wound complicationsWound complicationsNegative pressure wound therapyNegative pressure therapyVascular reconstructionGroin dissectionPressure therapyPICO dressingIncidence of groin wound complicationsProcedure indicationArterial reconstructionWound therapyIncidence of wound complicationsReduction of wound complicationsMultivariate logistic regression analysisAssociated with lower riskSurgical site infectionAntibiotics post-operativelyFemoral artery dissectionOpen vascular reconstructionLogistic regression analysisSzilagyi classificationGroin surgerySite infectionPatient demographicsRuptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica
Kostiuk V, Rodriguez P, Aboian E, Kuwayama D, Guzman R, Chaar C. Ruptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica. Vascular And Endovascular Surgery 2024, 59: 411-415. PMID: 39438778, DOI: 10.1177/15385744241296220.Peer-Reviewed Original ResearchCommon iliac artery aneurysmsIliac artery aneurysmsAbdominal aortic aneurysmArtery aneurysmRenal artery originsKidney transplantationAortic aneurysmEndovascular repairAneurysm repairArtery originLeft common iliac artery aneurysmConcomitant abdominal aortic aneurysmNon-contrast CT scanComplex aneurysm anatomyComplex aortoiliac aneurysmsIntra-abdominal aneurysmsFemoral-femoral bypassRinged PTFE graftEndovascular aneurysm repairKidney transplant functionFunctioning kidney transplantExternal iliac arteryRisk of ruptureSciatica symptomsAortoiliac aneurysmsThe Degree of Inferior Vena Cava Filter Tilt Associated with Challenging Retrieval
Kostiuk V, Grubman S, Brahmandam A, Schneider E, Tonnessen B, Perez Lozada J, Guzman R, Ochoa Chaar C. The Degree of Inferior Vena Cava Filter Tilt Associated with Challenging Retrieval. Annals Of Vascular Surgery 2024, 109: 135-142. PMID: 39025218, DOI: 10.1016/j.avsg.2024.06.020.Peer-Reviewed Original ResearchIVC filter tiltInferior vena cavaInferior vena cava filter retrievalFilter tiltEndovascular techniquesFilter retrievalInferior vena cava axisRight jugular vein accessInferior vena cava diameterElectronic charts of patientsInferior vena cava filter removalAssociated with technical difficultiesCharts of patientsFailed retrievalJugular vein accessLowest renal veinRight jugular veinRegression analysisFilter placementIVC filtersRenal veinVein accessVena cavaProcedural characteristicsFilter removalImpact of Updated Guidelines on Surgical Intervention and Surveillance Follow-Up in Patients with Abdominal Aortic Aneurysm: A Role for AI-Based Detection and Surveillance
Wilson E, Yao K, Kostiuk V, Bader J, Loh S, Khosla P, Mojibian H, Fischer U, Chaar C, Aboian E. Impact of Updated Guidelines on Surgical Intervention and Surveillance Follow-Up in Patients with Abdominal Aortic Aneurysm: A Role for AI-Based Detection and Surveillance. Journal Of Vascular Surgery 2024, 79: e184. DOI: 10.1016/j.jvs.2024.03.233.Peer-Reviewed Original ResearchArtificial Intelligence Improves Initial Evaluation and Follow-up of Patients With AAAs
Kostiuk V, Rodriguez P, Loh S, Wilson E, Yao K, Bader J, Mojibian H, Fischer U, Guzman R, Kuwayama D, Chaar C, Aboian E. Artificial Intelligence Improves Initial Evaluation and Follow-up of Patients With AAAs. Journal Of Vascular Surgery 2024, 79: e131-e132. DOI: 10.1016/j.jvs.2024.03.163.Peer-Reviewed Original ResearchDistinct Population Characteristics Seen in Patients with Premature Atherosclerosis
Neifert A, Su D, Rodriguez P, Kostiuk V, Chaar C, Sumpio B. Distinct Population Characteristics Seen in Patients with Premature Atherosclerosis. Journal Of Vascular Surgery 2024, 79: e293. DOI: 10.1016/j.jvs.2024.03.378.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm
Kostiuk V, Vallabhajosyula P, Nassiri N, Tonnessen B. Thoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm. Annals Of Vascular Surgery - Brief Reports And Innovations 2024, 4: 100302. DOI: 10.1016/j.avsurg.2024.100302.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repairEndovascular aneurysm repairAneurysm repairAcute type B aortic dissectionAcute onset chest painWeeks of antibiotic treatmentType B aortic dissectionAnti-impulse therapyExclusion of hemorrhageOnset chest painAortic arch debranchingPost-operative courseB aortic dissectionComputed tomography angiogramThoracic aortic aneurysmZone 0 TEVARArch debranchingMediastinal infectionChest painContrast extravasationBack painAntibiotic treatmentAortic aneurysmPost-operativelyFollow-upLong-term limb salvage and functional outcomes for patients undergoing partial calcanectomy
Kostiuk V, Gazes M, Fereydooni S, Chaar C, Guzman R, Tonnessen B. Long-term limb salvage and functional outcomes for patients undergoing partial calcanectomy. Vascular 2024, 33: 395-403. PMID: 38631330, DOI: 10.1177/17085381241247627.Peer-Reviewed Original ResearchMajor limb amputationPeripheral arterial diseasePartial calcanectomyAmbulatory statusLimb amputationRisk of major limb amputationNon-invasive vascular testingRisk of amputationVascular testingAnkle brachial indexEnd-stage renal diseaseAbsence of peripheral arterial diseaseMultivariate logistic regression analysisLogistic regression analysisAssociated with increased mortalityAmputation-free survivalHeel ulcersChronic heel ulcersLower extremity revascularizationBrachial indexSecondary outcomesPrimary outcomePodiatric procedureAmputationCalcanectomy