2024
Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions.
Kostiuk V, Fereydooni S, Setia O, Loh S, Strosberg D, Tonnessen B, Ochoa Chaar C, Aboian E. Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions. Vascular 2024, 17085381241296606. PMID: 39460535, DOI: 10.1177/17085381241296606.Peer-Reviewed Original ResearchGroin wound complicationsWound complicationsNegative pressure wound therapyNegative pressure therapyVascular reconstructionGroin dissectionPressure therapyPICO dressingIncidence of groin wound complicationsProcedure indicationArterial reconstructionWound therapyIncidence of wound complicationsReduction of wound complicationsMultivariate logistic regression analysisAssociated with lower riskSurgical site infectionAntibiotics post-operativelyFemoral artery dissectionOpen vascular reconstructionLogistic regression analysisSzilagyi classificationGroin surgerySite infectionPatient demographicsRuptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica.
Kostiuk V, Rodriguez P, Aboian E, Kuwayama D, Guzman R, Ochoa Chaar C. Ruptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica. Vascular And Endovascular Surgery 2024, 15385744241296220. PMID: 39438778, DOI: 10.1177/15385744241296220.Peer-Reviewed Original ResearchCommon iliac artery aneurysmsIliac artery aneurysmsAbdominal aortic aneurysmArtery aneurysmRenal artery originsKidney transplantationAortic aneurysmEndovascular repairAneurysm repairArtery originLeft common iliac artery aneurysmConcomitant abdominal aortic aneurysmNon-contrast CT scanComplex aneurysm anatomyComplex aortoiliac aneurysmsIntra-abdominal aneurysmsFemoral-femoral bypassRinged PTFE graftEndovascular aneurysm repairKidney transplant functionFunctioning kidney transplantExternal iliac arteryRisk of ruptureSciatica symptomsAortoiliac aneurysmsThe Degree of Inferior Vena Cava Filter Tilt Associated with Challenging Retrieval
Kostiuk V, Grubman S, Brahmandam A, Schneider E, Tonnessen B, Perez Lozada J, Guzman R, Ochoa Chaar C. The Degree of Inferior Vena Cava Filter Tilt Associated with Challenging Retrieval. Annals Of Vascular Surgery 2024, 109: 135-142. PMID: 39025218, DOI: 10.1016/j.avsg.2024.06.020.Peer-Reviewed Original ResearchIVC filter tiltInferior vena cavaInferior vena cava filter retrievalFilter tiltEndovascular techniquesFilter retrievalInferior vena cava axisRight jugular vein accessInferior vena cava diameterElectronic charts of patientsInferior vena cava filter removalAssociated with technical difficultiesCharts of patientsFailed retrievalJugular vein accessLowest renal veinRight jugular veinRegression analysisFilter placementIVC filtersRenal veinVein accessVena cavaProcedural characteristicsFilter removalImpact of Updated Guidelines on Surgical Intervention and Surveillance Follow-Up in Patients with Abdominal Aortic Aneurysm: A Role for AI-Based Detection and Surveillance
Wilson E, Yao K, Kostiuk V, Bader J, Loh S, Khosla P, Mojibian H, Fischer U, Chaar C, Aboian E. Impact of Updated Guidelines on Surgical Intervention and Surveillance Follow-Up in Patients with Abdominal Aortic Aneurysm: A Role for AI-Based Detection and Surveillance. Journal Of Vascular Surgery 2024, 79: e184. DOI: 10.1016/j.jvs.2024.03.233.Peer-Reviewed Original ResearchArtificial Intelligence Improves Initial Evaluation and Follow-up of Patients With AAAs
Kostiuk V, Rodriguez P, Loh S, Wilson E, Yao K, Bader J, Mojibian H, Fischer U, Guzman R, Kuwayama D, Chaar C, Aboian E. Artificial Intelligence Improves Initial Evaluation and Follow-up of Patients With AAAs. Journal Of Vascular Surgery 2024, 79: e131-e132. DOI: 10.1016/j.jvs.2024.03.163.Peer-Reviewed Original ResearchDistinct Population Characteristics Seen in Patients with Premature Atherosclerosis
Neifert A, Su D, Rodriguez P, Kostiuk V, Chaar C, Sumpio B. Distinct Population Characteristics Seen in Patients with Premature Atherosclerosis. Journal Of Vascular Surgery 2024, 79: e293. DOI: 10.1016/j.jvs.2024.03.378.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm
Kostiuk V, Vallabhajosyula P, Nassiri N, Tonnessen B. Thoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm. Annals Of Vascular Surgery - Brief Reports And Innovations 2024, 4: 100302. DOI: 10.1016/j.avsurg.2024.100302.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repairEndovascular aneurysm repairAneurysm repairAcute type B aortic dissectionAcute onset chest painWeeks of antibiotic treatmentType B aortic dissectionAnti-impulse therapyExclusion of hemorrhageOnset chest painAortic arch debranchingPost-operative courseB aortic dissectionComputed tomography angiogramThoracic aortic aneurysmZone 0 TEVARArch debranchingMediastinal infectionChest painContrast extravasationBack painAntibiotic treatmentAortic aneurysmPost-operativelyFollow-upLong-term limb salvage and functional outcomes for patients undergoing partial calcanectomy.
Kostiuk V, Gazes M, Fereydooni S, Chaar C, Guzman R, Tonnessen B. Long-term limb salvage and functional outcomes for patients undergoing partial calcanectomy. Vascular 2024, 17085381241247627. PMID: 38631330, DOI: 10.1177/17085381241247627.Peer-Reviewed Original ResearchMajor limb amputationPeripheral arterial diseasePartial calcanectomyAmbulatory statusLimb amputationRisk of major limb amputationNon-invasive vascular testingRisk of amputationVascular testingAnkle brachial indexEnd-stage renal diseaseAbsence of peripheral arterial diseaseMultivariate logistic regression analysisLogistic regression analysisAssociated with increased mortalityAmputation-free survivalHeel ulcersChronic heel ulcersLower extremity revascularizationBrachial indexSecondary outcomesPrimary outcomePodiatric procedureAmputationCalcanectomyIncorporation of Artificial Intelligence Into Abdominal Aortic Aneurysm Care in a Tertiary Care Center
Aboian E, Kostiuk V, Chaar C, Fischer U. Incorporation of Artificial Intelligence Into Abdominal Aortic Aneurysm Care in a Tertiary Care Center. Journal Of Vascular Surgery 2024, 79: 2s. DOI: 10.1016/j.jvs.2024.01.024.Peer-Reviewed Original ResearchRepresentation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years
Kostiuk V, Thaxton C, Loh S, Cardella J, Dardik A, Tonnessen B. Representation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years. JVS-Vascular Insights 2024, 2: 100077. DOI: 10.1016/j.jvsvi.2024.100077.Peer-Reviewed Original ResearchClinical trialsFemale vascular surgeonsVascular surgeonsMethods Clinical trialsArtery diseaseClinical trial leadershipSite principal investigatorsVascular conditionsAbdominal aortic aneurysmSurgeon-investigatorInvestigator-led trialsCarotid artery diseasePeripheral arterial diseaseCarotid diseaseProportion of womenVenous thrombectomyBoard certificationAortic aneurysmPercentage of womenIndustry-sponsored trialsTrial leadershipHemodialysis accessSubgroup analysisVascular surgerySurgeons
2023
The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval
Chaar C, Kostiuk V, Rodriguez P, Kim T, Rathbone D, Ghandour L, Burns R, Thorn S, Sinusas A, Guzman R, Dardik A. The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101731. PMID: 38081514, PMCID: PMC11523361, DOI: 10.1016/j.jvsv.2023.101731.Peer-Reviewed Original ResearchNext Generation IVC Filter Retrieval
Kostiuk V, Rodriguez P, Tonnessen B, Lozada J, Guzman R, Chaar C. Next Generation IVC Filter Retrieval. Journal Of Vascular Surgery 2023, 78: e130. DOI: 10.1016/j.jvs.2023.07.031.Peer-Reviewed Original ResearchEffect of inferior vena cava filter placement position on device complications
Grubman S, Kostiuk V, Brahmandam A, Tonnessen B, Mojibian H, Schneider E, Guzman R, Chaar C. Effect of inferior vena cava filter placement position on device complications. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 11: 1165-1174.e2. PMID: 37356713, DOI: 10.1016/j.jvsv.2023.05.020.Peer-Reviewed Original ResearchDevice-related mortalityDeep vein thrombosisIVC thrombosisIVC filtersRenal veinDevice complicationsCause mortalityPulmonary embolismVein thrombosisGroup CInferior vena cava filterAccess site hematomaPrimary end pointBaseline patient characteristicsSingle tertiary centerLong-term complicationsLong-term outcomesMultivariate logistic regressionRisk of thrombosisVena cava filtersLong-term thrombosisDistribution of sexEligible patientsSite hematomaPatient characteristicsEffect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT)
Kim T, Kostiuk V, Olson S, Curci J, Matsumura J, Baxter B, Blackwelder W, Terrin M, Guzman R. Effect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT). Annals Of Vascular Surgery 2023, 104: 1-9. PMID: 37356652, PMCID: PMC10748791, DOI: 10.1016/j.avsg.2023.06.019.Peer-Reviewed Original ResearchAbdominal Aortic Aneurysm Clinical TrialSerum MMP-3MMP-9 levelsArterial calcificationEffect of doxycyclineNon-invasive treatmentMMP-3Clinical trialsTomography scanMatrix metalloproteinasesSmall aortic aneurysmsArtery calcificationBaseline characteristicsPlacebo armCalcium scoreStudy armsAortic aneurysmPreclinical modelsMean changeAbdominal vesselsPatientsIndividual arteriesMatrix degradingDoxycyclineCalcificationHybrid Revision of Dysfunctional Aneurysmal Arteriovenous Fistulas
Kostiuk V, Chen J, Dahl N, Turner J, Chaar C. Hybrid Revision of Dysfunctional Aneurysmal Arteriovenous Fistulas. Vascular And Endovascular Surgery 2023, 57: 909-913. PMID: 37300698, DOI: 10.1177/15385744231183488.Peer-Reviewed Original ResearchAuthor Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2023, 14: 3264. PMID: 37277326, PMCID: PMC10241910, DOI: 10.1038/s41467-023-39025-z.Peer-Reviewed Original ResearchExtensive Proximal Thoracic Endovascular Aortic Repair Coverage Is Associated with Adverse Cardiac Impact
Harris S, Aboian E, Kostiuk V, Cardella J, Guzman R, Chaar C, Strosberg D, Elefteriades J. Extensive Proximal Thoracic Endovascular Aortic Repair Coverage Is Associated with Adverse Cardiac Impact. Journal Of Vascular Surgery 2023, 77: e279-e280. DOI: 10.1016/j.jvs.2023.03.389.Peer-Reviewed Original ResearchAortic Calcification Is Associated with Decreased Abdominal Aortic Aneurysm Growth
Olson S, Kim T, Kostiuk V, Curci J, Matsumura J, Baxter B, Blackwelder W, Terrin M, Guzman R. Aortic Calcification Is Associated with Decreased Abdominal Aortic Aneurysm Growth. Journal Of Vascular Surgery 2023, 77: e246-e247. DOI: 10.1016/j.jvs.2023.03.346.Peer-Reviewed Original Research
2022
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.Peer-Reviewed Original ResearchConceptsPluripotent cellsAdult tissue homeostasisCell fate commitmentDifferentiated cell fatesLeft-right patterningPluripotent embryonic cellsHuman embryonic stem cellsTemporal transcriptome analysisGene regulatory networksExpense of differentiationEmbryonic stem cellsGerm layer differentiationMembrane depolarizationFate commitmentPluripotent stateCell fateTranscriptome analysisRegulatory networksMyogenic lineageEmbryonic developmentTissue homeostasisDifferentiated fateEmbryonic cellsCandidate genesPluripotencyKap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling
Hwang WY, Kostiuk V, González DP, Lusk CP, Khokha M. Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling. ELife 2022, 11: e70495. PMID: 36300792, PMCID: PMC9665845, DOI: 10.7554/elife.70495.Peer-Reviewed Original ResearchConceptsNuclear transport receptorsΒ-catenin nuclear transportNuclear transportΒ-cateninExcessive WntΒ-catenin nuclear importHeterologous model systemsΒ-catenin accumulatesPrimary embryonic axisNuclear transport machineryRan-dependent mannerNuclear localization signalTCF/LEF reporterPY-NLSNuclear importLocalization signalTransport machineryTransport receptorsResponsive genesEmbryonic developmentEmbryonic axisWnt signalingKey effectorsDirect bindingHuman diseases