2006
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet
Bailey M, Cantone A, Yan Q, MacGregor G, Leng Q, Amorim J, Wang T, Hebert S, Giebisch G, Malnic G. Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney International 2006, 70: 51-59. PMID: 16710355, DOI: 10.1038/sj.ki.5000388.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBartter SyndromeBiological TransportDietDisease Models, AnimalHypokalemiaKidney Tubules, DistalLarge-Conductance Calcium-Activated Potassium ChannelsLoop of HenleMiceMice, Mutant StrainsPeptidesPotassiumPotassium Channels, Inwardly RectifyingPotassium, DietaryConceptsLate distal tubuleType II Bartter's syndromePotassium secretionDistal tubulesPotassium excretionRenal potassiumBartter's syndromeUrinary potassium excretionRenal potassium excretionRenal potassium lossFree-flow micropunctureDistal convoluted tubuleWild-type miceLoop of HenleThick ascending limbSalt-wasting disorderPersistent hypokalemiaMaxi-K channelsMouse modelConvoluted tubulesK secretionStationary microperfusionAscending limbHenle's loopSyndrome
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsLate distal tubuleEarly distal tubuleAng IIDistal tubulesRat kidneyAng II receptor antagonistsAngiotensin II stimulatesAngiotensin receptor blockersII receptor antagonistsInitial collecting tubuleLuminal administrationCortical nephronsAngiotensin IIIntravenous infusionReceptor antagonistTubular perfusateDistal nephronLuminal applicationCollecting tubuleProximal tubulesSeparate perfusionHigh dosesLow dosesHormone effectsNephron segments
1993
Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule.
Wang T, Malnic G, Giebisch G, Chan Y. Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule. Journal Of Clinical Investigation 1993, 91: 2776-2784. PMID: 8390489, PMCID: PMC443344, DOI: 10.1172/jci116519.Peer-Reviewed Original ResearchConceptsLate distal tubuleEarly distal tubuleDistal tubulesBicarbonate absorptionTubule segmentsFluid absorptionBicarbonate transportLuminal bicarbonate concentrationNet bicarbonate transportRenal bicarbonate reabsorptionLow K dietDistal tubule segmentsBicarbonate concentrationK-ATPase inhibitorPmol/minK dietBicarbonate secretionMicroperfusion experimentsBicarbonate reabsorptionH-ATPaseTubulesBafilomycin A1High rateRatsATPase inhibitor
1989
Neural control of distal tubular bicarbonate and fluid transport
Wang T, Chan Y. Neural control of distal tubular bicarbonate and fluid transport. American Journal Of Physiology 1989, 257: f72-f76. PMID: 2750926, DOI: 10.1152/ajprenal.1989.257.1.f72.Peer-Reviewed Original ResearchConceptsDistal tubulesRenal nerve activityProximal tubular reabsorptionEarly distal tubuleEffects of denervationLate distal tubuleDenervated kidneysReabsorb bicarbonateSham denervationNerve activityElectrolyte excretionTubular reabsorptionNeural regulationDenervationFluid reabsorptionBicarbonate absorptionFluid absorptionFluid samplesNeural controlVolume markerMicroperfusion methodTubulesBicarbonate concentrationJHCO3Reabsorption