2024
Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records
Miranda O, Kiehl S, Qi X, Brannock M, Kosten T, Ryan N, Kirisci L, Wang Y, Wang L. Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records. BMC Medical Informatics And Decision Making 2024, 24: 154. PMID: 38835009, PMCID: PMC11151516, DOI: 10.1186/s12911-024-02554-8.Peer-Reviewed Original ResearchConceptsNatural language processingPost-traumatic stress disorderPost-traumatic stress disorder patientsRDoC domainsLanguage processingAbnormal instancesLeverage natural language processingDiagnosis of post-traumatic stress disorderDomain criteriaSimilarity threshold valueF1-macro scorePositive valence systemsHeightened cue reactivityElectronic medical recordsClinical notesF1 scoreCue reactivityStress disorderRDoCValence systemsReal-timeMental health improvementDisease trajectoryExtraction researchSensorimotor disturbancesVaccines as Immunotherapies for Substance Use Disorders
Kosten T. Vaccines as Immunotherapies for Substance Use Disorders. American Journal Of Psychiatry 2024, 181: 362-371. PMID: 38706331, DOI: 10.1176/appi.ajp.20230828.Peer-Reviewed Original ResearchConceptsSubstance use disordersHuman clinical trials of vaccinesPreclinical vaccine studiesClinical trials of vaccinesVaccine clinical trialsHuman clinical trialsTrials of vaccinesVaccine immunotherapyIllicit fentanyl useOpioid pharmacotherapyEffective therapySubstance use disorder treatmentFentanyl useClinical trialsVaccine studiesAnimal modelsAnimal studiesUse disorderVaccine technologyLethal overdoseImmunotherapyVaccineLimited treatment accessFentanyl overdoseTreatment accessEfficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
Yao Y, Guo D, Lu T, Liu F, Huang S, Diao M, Li S, Zhang X, Kosten T, Shi J, Bao Y, Lu L, Han Y. Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research 2024, 335: 115886. PMID: 38574699, DOI: 10.1016/j.psychres.2024.115886.Peer-Reviewed Original ResearchConceptsMental disordersTreatment of mental disordersBorderline personality disorderObsessive-compulsive disorderTreat mood disordersSubstance-use disordersBody dysmorphic disorderPersonality disorderMood disordersDysmorphic disorderNegative moodEating disordersLasting adverse effectsTobacco addictionPsychedelicsDisordersTreat symptomsPsilocybinSleep disordersAyahuascaTherapeutic effectMeta-analyzedLSDPTSDMDMADeep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample
Cinciripini P, Wetter D, Wang J, Yu R, Kypriotakis G, Kumar T, Robinson J, Cui Y, Green C, Bergen A, Kosten T, Scherer S, Shete S. Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. Scientific Reports 2024, 14: 6385. PMID: 38493193, PMCID: PMC10944542, DOI: 10.1038/s41598-024-56750-7.Peer-Reviewed Original ResearchConceptsIdentification of novel lociSequencing of candidate genesRare variant associationsMapped to genesReceptor signaling pathwayNovel lociGenes associated with regulationVariant associationsCandidate genesProtective lociDeep sequencingRegulation of bodyweightGenetic studiesCanonical pathwaysSignaling pathwayRare variantsGenetic profileTarget of pharmacotherapyTumor suppressionAssociated with cancerGenesPublic health tollRandomized controlled trialsSubstance use disordersEthnically diverse samplePrediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models
Miranda O, Fan P, Qi X, Wang H, Brannock M, Kosten T, Ryan N, Kirisci L, Wang L. Prediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models. Drug And Alcohol Dependence 2024, 255: 111066. PMID: 38217979, PMCID: PMC10853953, DOI: 10.1016/j.drugalcdep.2023.111066.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol use disorderComorbid post-traumatic stress disorderStress disorderUse disorderCognitive behavioral therapyElectronic medical recordsBehavioral therapyMental disordersNeighborhood-level social determinants of healthNeighborhood-level social determinantsSocial determinants of healthArea under the receiver operating curveDeterminants of healthVeteran dataMedical recordsDisordersPsychotherapyPrediction of adverse eventsVeteran statusPatient's increased riskHigh-risk populationAnalyzed electronic medical recordsUniversity of Pittsburgh Medical CenterAdverse events
1989
Rapid detoxification from opioid dependence
Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Rapid detoxification from opioid dependence. American Journal Of Psychiatry 1989, 146: 1349a-1349. PMID: 2675644, DOI: 10.1176/ajp.146.10.1349a.Peer-Reviewed Original Research