Luis Farhat, MD, PhD
Associate Research Scientist in the Child Study CenterCards
About
Research
Publications
2025
Racial, Ethnic and Sex Representation in Tourette's Syndrome Clinical Trials: A Meta‐Analysis
Behling E, Farhat L, Landeros‐Weisenberger A, Bloch M. Racial, Ethnic and Sex Representation in Tourette's Syndrome Clinical Trials: A Meta‐Analysis. Movement Disorders Clinical Practice 2025 PMID: 41392858, DOI: 10.1002/mdc3.70457.Peer-Reviewed Original ResearchRandomized Controlled TrialsParticipation-to-prevalence ratioRandom-effects meta-analysisMeta-analysisProportion of trial participantsEvidence-based treatmentsClinical trialsReporting of raceHealth disparitiesProportion of individualsTS medicationEthnicity dataWeb of Science Core CollectionUS populationTrial participantsMeta-RegressionMinority participantsSex subgroupsScience Core CollectionPrimary outcomeMinority individualsTourette syndromeDisparitiesParticipantsTemporal trendsBenefits and harms of ADHD interventions: umbrella review and platform for shared decision making
Gosling C, Garcia-Argibay M, De Prisco M, Arrondo G, Ayrolles A, Antoun S, Caparos S, Catalán A, Ellul P, Dobrosavljevic M, Farhat L, Fico G, Eudave L, Groenman A, Højlund M, Jurek L, Nourredine M, Oliva V, Parlatini V, Psyllou C, Salazar-de-Pablo G, Tomlinson A, Westwood S, Cipriani A, Correll C, Yon D, Larsson H, Ostinelli E, Shin J, Fusar-Poli P, Ioannidis J, Radua J, Solmi M, Delorme R, Cortese S. Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making. The BMJ 2025, 391: e085875. PMID: 41297970, PMCID: PMC12651917, DOI: 10.1136/bmj-2025-085875.Peer-Reviewed Original ResearchConceptsNon-drug interventionsModerate certainty evidenceAttention deficit/hyperactivity disorder symptomsAttention deficit/hyperactivity disorderEvidence certaintyUmbrella reviewMeta-analysesSeverity of ADHD symptomsEffect sizeCertainty evidenceMeta-analyses of randomised controlled trialsMedium to large effect sizesRandomised controlled trialsADHD symptomsLarge effect sizesQuality of lifeLiving evidence synthesisAMSTAR-2Diagnosis of attention deficit/hyperactivity disorderCognitive behavioral therapyEvidence synthesisMethodological qualityDecision makingGuideline developmentDaily functioningEditorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome
Hardeman L, Farhat L, Koenig J, Bloch M. Editorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome. Journal Of Child Psychology And Psychiatry 2025, 66: 1781-1783. PMID: 41216975, DOI: 10.1111/jcpp.70075.Peer-Reviewed Original ResearchConceptsEndocannabinoid systemPsychiatric disordersTourette syndromeTreatment of psychiatric disordersMedicinal cannabisChronic tic disorderDevelopmental psychopathologyTic disordersPsychological phenomenaChild psychiatryBrain developmentCannabisTouretteDisordersPsychopathologyResearch review articleJCPPPsychiatryBrainSyndromeEvidenceChildrenReview articleLifespanDrugPsychotic symptoms during pharmacological treatment of ADHD: clinical considerations and research needs
Cortese S, Garcia-Argibay M, Oliver D, Chang Z, Farhat L, Bloch M, de Pablo G, Larsson H, Solmi M, Correll C, Fusar-Poli P. Psychotic symptoms during pharmacological treatment of ADHD: clinical considerations and research needs. The Lancet Psychiatry 2025 PMID: 41115444, DOI: 10.1016/s2215-0366(25)00248-2.Peer-Reviewed Original ResearchManagement of psychotic symptomsPsychotic symptomsADHD medicationPharmacological treatmentADHD pharmacotherapyPharmacological treatment of ADHDTreatment of ADHDBenefits of pharmacological treatmentOccurrence of psychotic disordersPsychotic disordersADHDMedication typePsychosisEvidence-based preventionPharmacotherapyClinical considerationsSymptomsMedicationIndividualsMethylphenidateClinical managementClinical practiceVulnerabilityResearch prioritiesDisorders7. INVESTIGATING POLYGENIC RISK AND RARE CNVS IN PARENT-OFFSPRING TRIOS WITH TRICHOTILLOMANIA AND EXCORIATION DISORDER
Greenspun S, Milanes I, Farhat L, Abdallah S, Bok D, Chen D, Liu W, Teefe E, Bloch M, Fernandez T, Olfson E. 7. INVESTIGATING POLYGENIC RISK AND RARE CNVS IN PARENT-OFFSPRING TRIOS WITH TRICHOTILLOMANIA AND EXCORIATION DISORDER. European Neuropsychopharmacology 2025, 99: 55-56. DOI: 10.1016/j.euroneuro.2025.08.112.Peer-Reviewed Original ResearchRare copy-number variantsCopy-number variantsPolygenic transmission disequilibrium testParent-offspring triosNeurodevelopmental risk genesGenetic architecturePolygenic risk scoresConstrained genesRisk genesAssociated with neurodevelopmental disordersExploratory pathway analysisGenomic studiesIntolerant to loss-of-function variationGenome-wide association studiesLoss-of-function variationPolygenic riskGenome-wide approachesRare De NovoRare genetic variantsTransmission disequilibrium testBody-focused repetitive behavior disordersRare CNVsElevated burdenRare deletionsAssociation studies2.45 Moderators of Evidence-Based Treatments for Pediatric OCD: A Preregistered Analysis of a Randomized Trial
Borja T, Seda L, Farhat L, Batistuzzo M, Fatori D. 2.45 Moderators of Evidence-Based Treatments for Pediatric OCD: A Preregistered Analysis of a Randomized Trial. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 64: s207. DOI: 10.1016/j.jaac.2025.08.165.Peer-Reviewed Original Research6.64 Is Screen Use Associated With Internalizing Symptoms in 36-Month-Old Children? Preliminary Findings From the Gemina Cohort
Borja T, Polanczyk G, Farhat L, Zuccolo P, Fatori D. 6.64 Is Screen Use Associated With Internalizing Symptoms in 36-Month-Old Children? Preliminary Findings From the Gemina Cohort. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 64: s325. DOI: 10.1016/j.jaac.2025.08.540.Peer-Reviewed Original Research2.15 Diagnostic Persistence of Preschool ADHD: 4-Year Follow-Up Analysis
De Sousa Gurgel W, Sugaya L, de Medeiros Filho M, Farhat L, Polanczyk G. 2.15 Diagnostic Persistence of Preschool ADHD: 4-Year Follow-Up Analysis. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 64: s199. DOI: 10.1016/j.jaac.2025.08.135.Peer-Reviewed Original ResearchMapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis
Shakeshaft A, Farhat L, Dennison C, Eyre O, Oginni O, O'Donovan M, Stringaris A, Leibenluft E, Polanczyk G, Riglin L, Thapar A. Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. Journal Of Child Psychology And Psychiatry 2025 PMID: 40974183, DOI: 10.1111/jcpp.70040.Peer-Reviewed Original ResearchShort Mood and Feelings QuestionnaireMillennium Cohort StudyStrengths and Difficulties QuestionnaireAvon Longitudinal StudyPolygenic scoresOdd-itemBehavior problemsCore symptomsMood and Feelings QuestionnaireAvon Longitudinal Study of ParentsAdolescent mental health servicesDepression polygenic scoresLongitudinal Study of ParentsCore symptoms of ADHDADHD polygenic scoresMental health servicesICD-11 approachOppositional defiant disorderSymptoms of ADHDStudy of parentsHealth servicesFeelings QuestionnaireADHD phenotypeAdolescent irritabilityMood disordersModerators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder
Farhat L, Sugaya L, Bloch M, Childress A, Cortese S, Fatori D, Salum G, Rohde L, Polanczyk G. Moderators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025 PMID: 40975435, DOI: 10.1016/j.jaac.2025.09.012.Peer-Reviewed Original ResearchADHD symptom severityAttention-deficit/hyperactivity disorderPreschool attention-deficit/hyperactivity disorderEfficacy of stimulationSymptom severityPost hoc natureRandomized placebo-controlled trialModerators of responseAttention-deficit/hyperactivitySymptom severity scoresPlacebo-controlled trialPredictor effectsPreschool childrenPreschoolOlder ageLinear mixed-effects modelsRandom-effects meta-analysesPlaceboMixed-effects modelsWhite childrenModeratelyTreatment effectsBlack childrenDisordersIndividual-level participant data
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