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INFORMATION FOR

    Lloyd G. Cantley, MD

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology
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    Additional Titles

    Vice Chair, Research

    Co-director of Education, Yale Center for Clinical Investigation

    About

    Titles

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology

    Vice Chair, Research; Co-director of Education, Yale Center for Clinical Investigation

    Biography

    Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury.

    Appointments

    • Nephrology

      Professor
      Primary

    • Cellular & Molecular Physiology

      Professor
      Secondary

    Other Departments & Organizations

    Education & Training

    Nephrology Fellow
    Beth Israel Hospital, Harvard Medical School (1990)
    Resident
    University of North Carolina (1984)
    MD
    West Virginia University (1981)
    BS
    West Virginia Wesleyan College (1977)

    Research

    Overview

    The primary focus of our laboratory is to determine the mechanisms of renal tubule development, homeostasis and repair. When the kidney is injured following ischemia or toxin exposure, the remaining epithelial cells de-differentiate, spread over the denuded basement membrane, divide, and re-arrange themselves in a specific pattern to regenerate functional tubules. This process requires a complex array of events involving rearrangement of cell shape and regulation of cell-matrix and cell-cell interactions. By examining epithelial cell adhesion, migration, and branching tubulogenesis in response to growth factors such as Hepatocyte Growth Factor and chitin's 3-like 1, we are determining the intracellular signaling events critical for tubule formation during kidney development and following injury. We have focused these efforts on the role of activation of specific MAPK isoforms as well as the PI 3-kinase in the regulation of cell morphogenesis and cell-matrix interactions.

    In addition, we are examining the role of the innate immune response to kidney injury and found that macrophages home to the injured kidney and initially promote apoptosis of sublethally injured tubular cells. Subsequent macrophage accumulation includes increasing numbers of alternatively activated macrophages that promote the survival and proliferation of the remaining tubular cells to effect tubule repair. We are currently expanding this work to study human acute kidney injury and have developed the use of Imaging Mass Cytometry in the human kidney.

    Medical Research Interests

    Epithelial Cells; Kidney; Macrophages; Morphogenesis; Nephrology; Physiology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Lloyd G. Cantley's published research.

    Publications

    2024

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    Clinical Care

    Overview

    Lloyd G. Cantley, MD, is a nephrologist whose clinical practice focuses on kidney disorders such as acute kidney injury, kidney dysfunction, chronic kidney disease and electrolyte imbalances. He is the C. N. H. Long Professor of Medicine in nephrology, professor of cellular and molecular physiology, and co-director of education at the Yale Center for Clinical Investigation.

    Dr. Cantley's research explores acute kidney injury, polycystic kidney disease, chronic kidney disease, and the immune system's involvement in kidney disease. His interests include the causes of acute injury and how repair can be optimized, progression of kidney diseases, and the link between kidney diseases and general health.

    Dr. Cantley has received awards and support from organizations such as the National Center for Advancing Translational Sciences, the American Heart Association, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Department of Defense.

    Clinical Specialties

    Nephrology; Internal Medicine

    Board Certifications

    • Nephrology

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1988

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1984

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    Contacts

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    Academic Office Number
    Appointment Number
    Lab Number
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    Administrative Support

    Locations

    • Yale Nephrology

      Academic Office

      The Anlyan Center

      300 Cedar Street, Ste Room S261

      New Haven, CT 06519

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    • Patient Care Locations

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