TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma
Jin K, Xu J, Su X, Xu Z, Li B, Liu G, Liu H, Wang Y, Zhu Y, Xu L, Zhang W, Liu Z, Wang Z, Chang Y, Xu J. TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma. The Journal Of Pathology 2024, 263: 139-149. PMID: 38380548, DOI: 10.1002/path.6266.Peer-Reviewed Original ResearchPD-1/PD-L1TP53 mutationsOverall survivalUrothelial carcinomaGenetic alterationsClinical significance of TP53 mutationsPD-1/PD-L1 blockade therapyCD8<sup>+</sup> T cell infiltrationIncreased CD8<sup>+</sup> T cell infiltrationElevated tumor mutation burdenSignificance of TP53 mutationsPD-1/PD-L1 blockadeTP53 disruptive mutationsInflamed tumor microenvironmentPlatinum-based chemotherapyT cell infiltrationTumor immune microenvironmentTumor mutational burdenWild-type TP53P53 protein functionTP53 mutation statusSensitive to immunotherapyHeterogeneous clinical outcomesPoorer overall survivalImprove risk stratificationIntegrating molecular subtype and CD8+ T cells infiltration to predict treatment response and survival in muscle-invasive bladder cancer
Li B, Jin K, Liu Z, Su X, Xu Z, Liu G, Xu J, Liu H, Chang Y, Wang Y, Zhu Y, Wang Z, Xu L, Zhang W. Integrating molecular subtype and CD8+ T cells infiltration to predict treatment response and survival in muscle-invasive bladder cancer. Cancer Immunology, Immunotherapy 2024, 73: 66. PMID: 38430246, PMCID: PMC10908619, DOI: 10.1007/s00262-024-03651-3.Peer-Reviewed Original ResearchConceptsMuscle-invasive bladder cancerCD8+ T cell infiltrationT cell infiltrationMolecular subtypesBladder cancerEfficacy of antitumor responseElevated tumor mutation burdenPositive response to immunotherapyCD8+ T cellsPD-L1 expressionResponse to immunotherapyTumor mutational burdenResponse to chemotherapyOverall survival outcomesSubtype-specific treatmentAntitumor responsePD-L1Intrinsic subtypesMutational burdenZhongshan HospitalSurvival outcomesT cellsTreatment responseResultsAmong patientsCancer Genome Atlas