TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma
Jin K, Xu J, Su X, Xu Z, Li B, Liu G, Liu H, Wang Y, Zhu Y, Xu L, Zhang W, Liu Z, Wang Z, Chang Y, Xu J. TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma. The Journal Of Pathology 2024, 263: 139-149. PMID: 38380548, DOI: 10.1002/path.6266.Peer-Reviewed Original ResearchPD-1/PD-L1TP53 mutationsOverall survivalUrothelial carcinomaGenetic alterationsClinical significance of TP53 mutationsPD-1/PD-L1 blockade therapyCD8<sup>+</sup> T cell infiltrationIncreased CD8<sup>+</sup> T cell infiltrationElevated tumor mutation burdenSignificance of TP53 mutationsPD-1/PD-L1 blockadeTP53 disruptive mutationsInflamed tumor microenvironmentPlatinum-based chemotherapyT cell infiltrationTumor immune microenvironmentTumor mutational burdenWild-type TP53P53 protein functionTP53 mutation statusSensitive to immunotherapyHeterogeneous clinical outcomesPoorer overall survivalImprove risk stratificationIntegrative score based on CDK6, PD-L1 and TMB predicts response to platinum-based chemotherapy and PD-1/PD-L1 blockade in muscle-invasive bladder cancer
Su X, Jin K, Guo Q, Xu Z, Liu Z, Zeng H, Wang Y, Zhu Y, Xu L, Wang Z, Chang Y, Xu J. Integrative score based on CDK6, PD-L1 and TMB predicts response to platinum-based chemotherapy and PD-1/PD-L1 blockade in muscle-invasive bladder cancer. British Journal Of Cancer 2024, 130: 852-860. PMID: 38212482, PMCID: PMC10912081, DOI: 10.1038/s41416-023-02572-9.Peer-Reviewed Original ResearchMuscle-invasive bladder cancerImmune checkpoint blockadeResponse to ICBResponse to platinum-based chemotherapyPlatinum-based chemotherapyPD-L1Bladder cancerZhongshan HospitalPD-1/PD-L1 blockadePD-1/PD-L1Cox regression analysisKaplan-Meier survivalCheckpoint blockadeCDK6 expressionResponse scoresImmune microenvironmentTherapy responseClinical outcomesPoor prognosisCancer Genome AtlasClinical significanceChemotherapyClinical relevanceProgression of cell cycleCancer treatment