2024
Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Chen X, Strittmatter S, Lake E. Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity. Journal Of Neurotrauma 2024, 0 PMID: 39096127, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanisms
2021
A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Fesharaki-Zadeh A. A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player. The Neurologist 2021, 27: 249-252. PMID: 34879014, PMCID: PMC9439689, DOI: 10.1097/nrl.0000000000000391.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyAlzheimer's diseasePrior traumatic brain injuryBehavioral variant frontotemporal dementiaRepetitive head traumaTraumatic brain injuryPrior psychiatric historyPrimary progressive aphasiaVariant frontotemporal dementiaPositron emission tomographyCTE casesClinical presentationHead traumaCase reportClinical historyDefinitive diagnosisClinical algorithmBrain injuryComorbid moodPsychiatric historyCerebrospinal fluidNeuroimaging biomarkersProgressive aphasiaFrontotemporal dementia