2023
A membrane-associated MHC-I inhibitory axis for cancer immune evasion
Chen X, Lu Q, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, Cammer M, Wang K, Al-Santli W, Ciantra Z, Guo Q, You J, Sengupta D, Boukhris A, Zhang H, Liu C, Cresswell P, Dahia P, Pagano M, Aifantis I, Wang J. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. Cell 2023, 186: 3903-3920.e21. PMID: 37557169, PMCID: PMC10961051, DOI: 10.1016/j.cell.2023.07.016.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaSolid cancersImmune evasionCancer immune evasionImmune checkpoint blockadeMultiple solid cancersMajor Histocompatibility Complex Class I Antigen PresentationPotential therapeutic targetCell-dependent mannerCell immunityCancer survivalMyeloid leukemiaAntigen presentationTherapeutic targetTransmembrane protein 127Tumor growthGene signatureCancer treatmentCancerPeptide-MHCMHCLeukemiaSushi domainTrimolecular complexE3 ubiquitin ligase WWP2
2022
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression
Arshad N, Laurent-Rolle M, Ahmed W, Hsu J, Mitchell S, Pawlak J, Sengupta D, Biswas K, Cresswell P. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2208525120. PMID: 36574644, PMCID: PMC9910621, DOI: 10.1073/pnas.2208525120.Peer-Reviewed Original ResearchConceptsMHC-I expressionSARS-CoV-2Major histocompatibility complex (MHC) class I moleculesT cell recognitionVirus-infected cellsClass I moleculesAntigen presentationOngoing COVID-19 pandemicHeavy chainImmune evasionViral peptidesSecretory pathwayDistinct mechanismsMHCI moleculesPeptide-MHCInfected cellsCausative agentCell recognitionCD8COVID-19 pandemicViral proteinsEndoplasmic reticulumHuman MHCORF7a
2001
A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum
Diedrich G, Bangia N, Pan M, Cresswell P. A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum. The Journal Of Immunology 2001, 166: 1703-1709. PMID: 11160214, DOI: 10.4049/jimmunol.166.3.1703.Peer-Reviewed Original ResearchAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersCalcium-Binding ProteinsCalnexinCalreticulinCell Line, TransformedDimerizationEndoplasmic ReticulumHeat-Shock ProteinsHeLa CellsHistocompatibility Antigens Class IHLA AntigensHumansImmunoglobulinsIsomerasesKineticsMajor Histocompatibility ComplexMembrane Transport ProteinsProtein BindingProtein Disulfide-IsomerasesRibonucleoproteinsTumor Cells, Cultured
1997
A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes
Ortmann B, Copeman J, Lehner P, Sadasivan B, Herberg J, Grandea A, Riddell S, Tampé R, Spies T, Trowsdale J, Cresswell P. A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes. Science 1997, 277: 1306-1309. PMID: 9271576, DOI: 10.1126/science.277.5330.1306.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersCalcium-Binding ProteinsCalreticulinCell LineCell Line, TransformedChromosome MappingChromosomes, Human, Pair 6Cloning, MolecularDimerizationEndoplasmic ReticulumGenetic LinkageHistocompatibility Antigens Class IHLA AntigensHumansImmunoglobulin GImmunoglobulinsMajor Histocompatibility ComplexMembrane Transport ProteinsMolecular Sequence DataRibonucleoproteinsSequence Homology, Amino AcidT-Lymphocytes, CytotoxicTumor Cells, Cultured
1992
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
Wei M, Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 1992, 356: 443-446. PMID: 1557127, DOI: 10.1038/356443a0.Peer-Reviewed Original Research
1989
Differential transport requirements of HLA and H-2 class I glycoproteins
Alexander J, Payne J, Murray R, Frelinger J, Cresswell P. Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics 1989, 29: 380-388. PMID: 2731965, DOI: 10.1007/bf00375866.Peer-Reviewed Original Research
1987
Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily
Parham P, Lutz P, Cresswell P. Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily. Immunogenetics 1987, 26: 323-326. PMID: 2443449, DOI: 10.1007/bf00346533.Peer-Reviewed Original ResearchAn epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin
Lutz P, Cresswell P. An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin. Immunogenetics 1987, 25: 228-233. PMID: 2437022, DOI: 10.1007/bf00404692.Peer-Reviewed Original ResearchConceptsB-lymphoblastoid cell linesClass I heavy chainsWestern blottingClass I major histocompatibility complex antigensClass II MHC antigensMajor histocompatibility complex antigensClass IHLA class I heavy chainsClass II antigensHistocompatibility complex antigensHLA class IBeta-2-microglobulinLight chainHeavy chainNormal human serumWestern blot analysisMHC antigensII antigensComplex antigensImmunoglobulin light chainsM1 mAbΒ2-microglobulinMonoclonal antibodiesAntigenHuman immunoglobulinRegulation of HLA Class I and Class II antigen expression
Cresswell P. Regulation of HLA Class I and Class II antigen expression. British Medical Bulletin 1987, 43: 66-80. PMID: 3315102, DOI: 10.1093/oxfordjournals.bmb.a072177.Peer-Reviewed Original ResearchConceptsCell surfaceRegulatory genesTranscriptional levelHybridisation experimentsIntracellular transportThird glycoproteinHeterodimeric glycoproteinCell typesChondroitin sulfate proteoglycanEfficient assemblyCell linesSulfate proteoglycanEnhanced expressionT cell linesGenesClass IExpressionTissue distributionRegulationLymphoblastoid linesGlycoproteinUnusual complexityClass I moleculesInvariant chainBiosynthesis
1985
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter R, Howell D, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 1985, 21: 235-246. PMID: 3872841, DOI: 10.1007/bf00375376.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesFlow CytometryGene Expression RegulationHLA AntigensHumansHybrid CellsT-LymphocytesConceptsHLA class IClass II antigen expressionClass II antigensHLA-B antigensClass III antigensAntigen expressionLymphoblastoid cell linesTotal HLA class IHLA class II antigensHLA-A2 antigenHLA-B5 antigenHLA-A antigensB-lymphoblastoid cell linesCell linesHLA-DRHLA-B5HLA-A2B-LCLParental cell lineAntigenEnhanced expressionDecreased amountCEMRChromosome 6
1984
Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting
Radka S, Machamer C, Cresswell P. Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting. Human Immunology 1984, 10: 177-188. PMID: 6611328, DOI: 10.1016/0198-8859(84)90038-7.Peer-Reviewed Original ResearchConceptsMonomorphic monoclonal antibodiesClass II moleculesMonoclonal antibodiesBeta chainClass II beta chainPolymorphic monoclonal antibodiesHLA-DR5HLA-DRMonomorphic determinantsBeta subunitDeterminant absentPolymorphic antibodiesWestern blottingAntibodiesAntigen subunitsTwo-dimensional gel electrophoresisTwo-dimensional electrophoresisDR3Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids
Howell D, Kostyu D, Ting J, Cresswell P. Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. Somatic Cell And Molecular Genetics 1984, 10: 217-224. PMID: 6609440, DOI: 10.1007/bf01535244.Peer-Reviewed Original ResearchConceptsClass I histocompatibilityB-LCLLymphoblastoid cell linesB antigensPaucity of HLAHLA class I heavy chainsHLA-B antigensHLA-A antigensB-lymphoblastoid cell linesB antigen expressionClass I heavy chainsAntigen expressionB expressionHLAIndirect immunofluorescenceAntigenLow levelsClass IT-LCLHistocompatibilityCell linesHeavy chain mRNATotal levelsCEMRHeavy chain
1982
Monoclonal Antibody to HLA-A3
BERGER A, DAVIS J, CRESSWELL P. Monoclonal Antibody to HLA-A3. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1982, 1: 87-90. PMID: 6208124, DOI: 10.1089/hyb.1.1982.1.87.Peer-Reviewed Original Research
1981
HLA control of interferon production in the human mixed lymphocyte culture
Andreotti P, Cresswell P. HLA control of interferon production in the human mixed lymphocyte culture. Human Immunology 1981, 3: 109-120. PMID: 6173359, DOI: 10.1016/0198-8859(81)90048-3.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHLA AntigensHumansInterferonsKineticsLymphocyte Culture Test, MixedLymphocytesMale
1980
HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines
Andreotti P, Apgar J, Cresswell P. HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines. Human Immunology 1980, 1: 77-86. PMID: 7263311, DOI: 10.1016/0198-8859(80)90011-7.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesCell-mediated lympholysisHLA-A2T lymphocytesMixed lymphocyte responseHLA-A2 mutantsCell linesLymphocyte responsesHLA typingImmune precipitation analysisLymphocytesTarget cellsMolecular targetsSensitized cellsMutant cell linesComparable susceptibilityLympholysisHLAStaphylococcus aureus proteinPutative targetsAureus proteinNegative selectionCellsTargetSusceptibility
1977
Human B cell alloantigens: separation from other membrane molecules by affinity chromatography
Cresswell P. Human B cell alloantigens: separation from other membrane molecules by affinity chromatography. European Journal Of Immunology 1977, 7: 636-639. PMID: 303569, DOI: 10.1002/eji.1830070911.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesCell MembraneChromatography, AffinityDeoxycholic AcidHLA AntigensHumansIsoantigensMembrane ProteinsConceptsMolecular weight 35 000Sodium dodecyl sulfate gel electrophoresisDodecyl sulfate gel electrophoresisAffinity chromatographySulfate gel electrophoresisSoluble productsB-lymphoblastoid cell linesChromatographyMoleculesSodium deoxycholateLymphoblastoid cell linesGel electrophoresisAgarose columnIa-like alloantigensDeoxycholateCell linesHuman B cellsSeparationSpecific rabbit antibodiesB cellsColumnSerological activityElectrophoresisRabbit antibodiesMaterials
1976
HLA‐B specificities and w4, w6 specificities are on the same polypeptide
Ayres J, Cresswell P. HLA‐B specificities and w4, w6 specificities are on the same polypeptide. European Journal Of Immunology 1976, 6: 794-799. PMID: 63373, DOI: 10.1002/eji.1830061108.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCell LineEpitopesGenesHistocompatibility AntigensHLA AntigensHumansIsoantigensPeptidesConceptsHLA-B7HLA-B12HLA-B determinantsAntigenic determinantsDistinct antigenic determinantsDifferent antigenic determinantsHLA-B specificitiesHLA-B locusHLA-B locus productsSequential immunoprecipitation experimentsLymphoblastoid cell linesAntigen poolCell linesLocus productsHunter reagentSpecificityImmunoprecipitation experimentsPapain digestionDeterminantsDiallelic systemAlloantiseraSame polypeptideHLA antigens: rabbit antisera reacting with all A series or all B series specificities
Cresswell P, Ayres J. HLA antigens: rabbit antisera reacting with all A series or all B series specificities. European Journal Of Immunology 1976, 6: 82-88. PMID: 786698, DOI: 10.1002/eji.1830060203.Peer-Reviewed Original ResearchConceptsCytotoxicity of HLAHLA alloantiseraHLA antigensA2 substanceHuman peripheral blood lymphocytesPeripheral blood lymphocytesComplement-mediated cytotoxicityType of serumHLA-B12HLA-A2Blood lymphocytesHLA-B7Beta 2microglobulinHLAFragments of rabbitHLA lociCultured cell linesAntigenic determinantsAllelic productsRabbitsCell linesImmune precipitationRabbit antiserumAntigenAntiserum
1975
Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture
CRESSWELL P, GEIER S. Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture. Nature 1975, 257: 147-149. PMID: 51476, DOI: 10.1038/257147a0.Peer-Reviewed Original Research