Identification and functional study of the endoplasmic reticulum stress sensor IRE1 in Chlamydomonas reinhardtii
Yamaoka Y, Choi BY, Kim H, Shin S, Kim Y, Jang S, Song W, Cho CH, Yoon HS, Kohno K, Lee Y. Identification and functional study of the endoplasmic reticulum stress sensor IRE1 in Chlamydomonas reinhardtii. The Plant Journal 2018, 94: 91-104. PMID: 29385296, DOI: 10.1111/tpj.13844.Peer-Reviewed Original ResearchConceptsStress sensor IRE1Unfolded protein responseIre1 mutantsER stress responseMarker gene expressionGene expressionTandem zinc finger domainStress responseER stress sensor IRE1Cytosolic C-terminal regionEndoplasmic reticulum (ER) stress sensor IRE1Zinc finger domainER stress conditionsC-terminal regionN-terminal regionROS scavenger glutathioneER stress inducersStrain CCYeast Ire1pEvolutionary historyER homeostasisEndoplasmic reticulum stressChlamydomonas reinhardtiiProtein responseChimeric proteinEndoplasmic reticulum acyltransferase with prokaryotic substrate preference contributes to triacylglycerol assembly in Chlamydomonas
Kim Y, Terng EL, Riekhof WR, Cahoon EB, Cerutti H. Endoplasmic reticulum acyltransferase with prokaryotic substrate preference contributes to triacylglycerol assembly in Chlamydomonas. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 1652-1657. PMID: 29382746, PMCID: PMC5816170, DOI: 10.1073/pnas.1715922115.Peer-Reviewed Original ResearchConceptsUnicellular green algaEndoplasmic reticulum membraneLysophosphatidic acid acyltransferaseChloroplastic pathwayPrecursor biosynthesisTAG precursorsNitrogen deprivationTriacylglycerol assemblyAssembly pathwayGreen algaTAG accumulationAcid acyltransferaseAcyl donor substratesReticulum membraneBiomaterial productionDonor substrateChlamydomonasTriacylglycerol metabolismPalmitoyl-CoAAcyltransferasePathwayMajor roleBiosynthesisAlgaRNA