Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance
Yang H, Qin Y, Li Y, Hu F. Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance. Biometrics 2024, 80: ujae047. PMID: 38801258, DOI: 10.1093/biomtc/ujae047.Peer-Reviewed Original ResearchConceptsCovariate balanceMarginal imbalanceAdaptive randomization methodsTreatment effect estimatesSequential allocation schemeModified Mahalanobis distanceRandomization methodSimulation studyCovariate imbalanceRandom processTheoretical guaranteesCovariatesImbalance measureEffect estimatesMahalanobis distanceCurrent patientSample size differencesMarginal balanceAllocation schemeConvergenceData analysisSuperior performance