Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates
Li Y, Ma W, Qin Y, Hu F. Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates. Statistical Methods In Medical Research 2021, 30: 2148-2164. PMID: 33899607, DOI: 10.1177/09622802211008206.Peer-Reviewed Original ResearchConceptsCovariate-adaptive randomizationCovariate-adaptive randomization methodsCovariate-adaptive randomized trialsValidity of statistical inferenceInflated type I errorLinear modelType I errorGeneralized linear modelAsymptotic distributionProposed adjustment methodAsymptotic resultsInferential propertiesTest statisticsAnti-conservativeStatistical inferenceContinuous responseUnadjusted testsNull hypothesisTheoretical findingsTreatment effectsInvalid testsRandomization methodNumerical studyCovariatesAdjustment method