2017
Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes
Chandra S, Kalaivani R, Kumar M, Srinivasan N, Sarkar D. Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes. Molecular Biology Of The Cell 2017, 28: 3801-3814. PMID: 29074568, PMCID: PMC5739296, DOI: 10.1091/mbc.e17-06-0400.Peer-Reviewed Original ResearchConceptsMembrane fusionQuantitative mass spectrometryTwo-dimensional differentialViral envelope glycoproteinsSendai viral envelopesEarly molecular eventsHost cell proteinsActin cytoskeletonThreonine 206Actin dynamicsSendai virusAnimal cellsMolecular eventsCellular membranesHost cellsCell proteinsFusion-mediated deliveryNovel mechanismBiochemical analysisVillinEnvelope glycoproteinGel electrophoresisViral envelopeProteinViral entry
2015
Membrane Fusion Mediated Targeted Cytosolic Drug Delivery Through scFv Engineered Sendai Viral Envelopes.
Kumar M, Mani P, Pratheesh P, Chandra S, Jeyakkodi M, Chattopadhyay P, Sarkar D, Sinha S. Membrane Fusion Mediated Targeted Cytosolic Drug Delivery Through scFv Engineered Sendai Viral Envelopes. 2015, 15: 386-400. PMID: 25941820, DOI: 10.2174/1566524015666150505155949.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsAntibiotics, AntineoplasticAntibodies, MonoclonalCell Line, TumorCHO CellsCricetinaeCricetulusCytoplasmDoxorubicinDrug Delivery SystemsFluorescein-5-isothiocyanateGPI-Linked ProteinsHeLa CellsHumansIsoenzymesMembrane FusionPeptide LibrarySendai virusStaining and LabelingViral Envelope ProteinsViral Fusion ProteinsConceptsOnco-fetal antigenF proteinNumber of malignanciesNative F proteinVariety of cancersAlkaline phosphataseViral envelopeCytoplasmic deliveryBreast cancerSendai viral envelopesSpecific antibodiesPAPPlacental isozymeCancerSpecific bindingAntibodiesDrugsDeliveryCytosolic drug deliveryPotential usefulnessRecombinant scFvReduced degradationHN proteinUbiquitous expression