2021
Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome
Chandra S, Mannino PJ, Thaller DJ, Ader NR, King MC, Melia TJ, Lusk CP. Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome. Journal Of Cell Biology 2021, 220: e202103030. PMID: 34714326, PMCID: PMC8575018, DOI: 10.1083/jcb.202103030.Peer-Reviewed Original ResearchMeSH KeywordsAutophagosomesAutophagyAutophagy-Related ProteinsCytoplasmic VesiclesGreen Fluorescent ProteinsNuclear EnvelopeProtein DomainsReceptors, Cytoplasmic and NuclearSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStructure-Activity RelationshipTime FactorsVacuolesVesicular Transport ProteinsConceptsInner nuclear membraneNuclear envelope lumenOuter nuclear membraneNuclear membraneSplit-GFP reporterNuclear envelope localizationINM proteinsAutophagy apparatusEnvelope localizationLumenal vesiclesLumenal domainCargo adaptorsAtg39Sequence elementsCorrelative lightVesiclesAutophagosomesMembraneNucleophagyAdaptorReporterProteinOverexpressionMotif
2017
Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes
Chandra S, Kalaivani R, Kumar M, Srinivasan N, Sarkar D. Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes. Molecular Biology Of The Cell 2017, 28: 3801-3814. PMID: 29074568, PMCID: PMC5739296, DOI: 10.1091/mbc.e17-06-0400.Peer-Reviewed Original ResearchConceptsMembrane fusionQuantitative mass spectrometryTwo-dimensional differentialViral envelope glycoproteinsSendai viral envelopesEarly molecular eventsHost cell proteinsActin cytoskeletonThreonine 206Actin dynamicsSendai virusAnimal cellsMolecular eventsCellular membranesHost cellsCell proteinsFusion-mediated deliveryNovel mechanismBiochemical analysisVillinEnvelope glycoproteinGel electrophoresisViral envelopeProteinViral entry