Emerging Connections between Nuclear Pore Complex Homeostasis and ALS
Chandra S, Lusk CP. Emerging Connections between Nuclear Pore Complex Homeostasis and ALS. International Journal Of Molecular Sciences 2022, 23: 1329. PMID: 35163252, PMCID: PMC8835831, DOI: 10.3390/ijms23031329.Peer-Reviewed Original ResearchConceptsNuclear pore complexNuclear envelopeQuality control pathwaysNuclear transport machineryNuclear transport receptorsQuality control mechanismsDipeptide repeat proteinsNew experimental avenuesNucleoporin proteinsRan GTPaseAmyotrophic lateral sclerosisTransport machineryPore complexRepeat proteinsSurveillance pathwayTransport receptorsRepeat RNANPC structureTransport proteinsControl pathwaysPatient neuronsComplex homeostasisHexanucleotide repeat expansionExperimental avenuesRepeat expansion