Pharmacogenomics polygenic risk score: Ready or not for prime time?
Singh S, Stocco G, Theken K, Dickson A, Feng Q, Karnes J, Mosley J, Rouby N. Pharmacogenomics polygenic risk score: Ready or not for prime time? Clinical And Translational Science 2024, 17: e13893. PMID: 39078255, PMCID: PMC11287822, DOI: 10.1111/cts.13893.Peer-Reviewed Original ResearchMeSH KeywordsGenome-Wide Association StudyHumansMultifactorial InheritancePharmacogeneticsPharmacogenomic VariantsPhenotypePrecision MedicineRisk AssessmentConceptsGenome wide association studiesDisease-associated variantsPharmacogenetic phenotypesPharmacogenomic researchPolygenic risk scoresDisease geneticsGenomic dataAssociation studiesPhenotypic inconsistenciesPolygenic natureGenetic variantsGenetic associationStratified treatment approachDrug responseClinical decision toolPrecision medicineClinical predictorsPhenotypeClinical useClinical implementationTreatment approachesRisk scoreVariantsGenomePatient education