Individualized Dose-Response to Statins Associated With Cardiovascular Disease Outcomes
Aggarwal S, Jiang L, Liu G, Grabowska M, Ong H, Wilke R, Feng Q, Wei W. Individualized Dose-Response to Statins Associated With Cardiovascular Disease Outcomes. JACC Advances 2024, 3: 100894. PMID: 38737008, PMCID: PMC11086740, DOI: 10.1016/j.jacadv.2024.100894.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseAtherosclerotic cardiovascular disease eventsLDL-CComposite primary end pointPrevention of atherosclerotic cardiovascular diseaseDose responseLow-density lipoprotein cholesterolBaseline LDL-CPrimary end pointAll-cause mortalityElectronic health record dataTime-to-event analysisHealth record dataCardiovascular disease outcomesIndividual dose responsesMultiple dosesClinical outcomesPrescribed statinsLipoprotein cholesterolHazard ratioStatinsEnd pointsDisease outcomeCardiovascular diseaseED50