2001
Defective Antigen Processing in GILT-Free Mice
Maric M, Arunachalam B, Phan U, Dong C, Garrett W, Cannon K, Alfonso C, Karlsson L, Flavell R, Cresswell P. Defective Antigen Processing in GILT-Free Mice. Science 2001, 294: 1361-1365. PMID: 11701933, DOI: 10.1126/science.1065500.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsAntigensCell LineDendritic CellsDisulfidesEpitopesHistocompatibility Antigens Class IIHybridomasHydrogen-Ion ConcentrationImmunizationMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMuramidaseOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsProtein ConformationProtein FoldingSpleenT-LymphocytesGlycosylation and the Immune System
Rudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System. Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Antibody ReactionsAntigen-Presenting CellsAntigens, CD1Carrier ProteinsCollectinsComplement System ProteinsEndoplasmic ReticulumEpitopesGlycoproteinsGlycosylationHistocompatibility AntigensHumansImmune SystemImmunoglobulinsPolysaccharidesProtein FoldingT-LymphocytesViral Envelope ProteinsConceptsImmune systemMajor histocompatibility complex antigensAntigen-presenting cellsAdaptive immune responsesCellular immune systemHistocompatibility complex antigensHumoral immune systemT cell receptor complexRheumatoid arthritisMannose-binding lectinAutoimmune diseasesCell receptor complexT cellsImmune responseComplex antigensPeptide antigensComplement componentsImmunoglobulin GAntigenKey moleculesReceptor complexSpecific glycoformsGlycoproteinGlycopeptide antigensArthritis
1996
Processing and delivery of peptides presented by MHC class I molecules
Lehner P, Cresswell P. Processing and delivery of peptides presented by MHC class I molecules. Current Opinion In Immunology 1996, 8: 59-67. PMID: 8729447, DOI: 10.1016/s0952-7915(96)80106-3.Peer-Reviewed Original ResearchAnimalsAntigen PresentationATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersCysteine EndopeptidasesCytotoxicity, ImmunologicEndoplasmic ReticulumEpitopesHistocompatibility Antigens Class IHumansInterferon-gammaMiceMice, KnockoutModels, MolecularMultienzyme ComplexesProteasome Endopeptidase Complex
1995
Different MHC class I alleles compete for presentation of overlapping viral epitopes
Tussey L, Rowland-Jones S, Zheng T, Androlewicz M, Cresswell P, Frelinger J, McMichael A. Different MHC class I alleles compete for presentation of overlapping viral epitopes. Immunity 1995, 3: 65-77. PMID: 7542549, DOI: 10.1016/1074-7613(95)90159-0.Peer-Reviewed Original Research
1987
Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily
Parham P, Lutz P, Cresswell P. Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily. Immunogenetics 1987, 26: 323-326. PMID: 2443449, DOI: 10.1007/bf00346533.Peer-Reviewed Original ResearchAn epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin
Lutz P, Cresswell P. An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin. Immunogenetics 1987, 25: 228-233. PMID: 2437022, DOI: 10.1007/bf00404692.Peer-Reviewed Original ResearchConceptsB-lymphoblastoid cell linesClass I heavy chainsWestern blottingClass I major histocompatibility complex antigensClass II MHC antigensMajor histocompatibility complex antigensClass IHLA class I heavy chainsClass II antigensHistocompatibility complex antigensHLA class IBeta-2-microglobulinLight chainHeavy chainNormal human serumWestern blot analysisMHC antigensII antigensComplex antigensImmunoglobulin light chainsM1 mAbΒ2-microglobulinMonoclonal antibodiesAntigenHuman immunoglobulinImmune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain
Ulrich R, Atassi H, Lutz P, Cresswell P, Atassi M. Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain. European Journal Of Immunology 1987, 17: 497-502. PMID: 2436923, DOI: 10.1002/eji.1830170410.Peer-Reviewed Original ResearchConceptsAntibody-binding activityHuman major histocompatibility antigensBeta chainMajor histocompatibility antigensAntigenic sitesHistocompatibility antigensImmune recognitionChain antiserumIsolated beta chainsMost antiseraAntiserumPeptide 81Continuous antigenic sitesΒ-chainPeptidesFirst domainHLAImmunodominanceAntigenComprehensive synthetic strategy
1984
HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same molecule
Radka S, Bernard Amos D, Quackenbush L, Cresswell P. HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same molecule. Immunogenetics 1984, 19: 63-76. PMID: 6198273, DOI: 10.1007/bf00364476.Peer-Reviewed Original ResearchConceptsClass II moleculesChimpanzee antiserumSame class II moleculesDR7 specificitiesSerologic specificityMonoclonal antibodiesBinding-inhibition studiesCell linesSame serologic specificityAllogeneic epitopesNoncytotoxic antibodiesHLA-DR7IgM antibodiesSpecific monoclonal antibodiesDR moleculesDifferent epitopesAntibodiesEpitopesBeta chainCytotoxic activityHomozygous cell linesAntiserumMembrane preparationsCytotoxicitySpecificity
1982
Monoclonal Antibody to HLA-A3
BERGER A, DAVIS J, CRESSWELL P. Monoclonal Antibody to HLA-A3. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1982, 1: 87-90. PMID: 6208124, DOI: 10.1089/hyb.1.1982.1.87.Peer-Reviewed Original Research
1980
A public HLA antigen associated with HLA-A9, Aw32, and Bw4
Kostyu D, Cresswell P, Amos D. A public HLA antigen associated with HLA-A9, Aw32, and Bw4. Immunogenetics 1980, 10: 433-442. PMID: 22457917, DOI: 10.1007/bf01572579.Peer-Reviewed Original Research
1976
HLA‐B specificities and w4, w6 specificities are on the same polypeptide
Ayres J, Cresswell P. HLA‐B specificities and w4, w6 specificities are on the same polypeptide. European Journal Of Immunology 1976, 6: 794-799. PMID: 63373, DOI: 10.1002/eji.1830061108.Peer-Reviewed Original ResearchConceptsHLA-B7HLA-B12HLA-B determinantsAntigenic determinantsDistinct antigenic determinantsDifferent antigenic determinantsHLA-B specificitiesHLA-B locusHLA-B locus productsSequential immunoprecipitation experimentsLymphoblastoid cell linesAntigen poolCell linesLocus productsHunter reagentSpecificityImmunoprecipitation experimentsPapain digestionDeterminantsDiallelic systemAlloantiseraSame polypeptide
1975
Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture
CRESSWELL P, GEIER S. Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture. Nature 1975, 257: 147-149. PMID: 51476, DOI: 10.1038/257147a0.Peer-Reviewed Original Research
1974
Immunological Identity of the Small Subunit of HL-A Antigens and β2-Microglobulin and Its Turnover on the Cell Membrane
Cresswell P, Springer T, Strominger J, Turner M, Grey H, Kubo R. Immunological Identity of the Small Subunit of HL-A Antigens and β2-Microglobulin and Its Turnover on the Cell Membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 1974, 71: 2123-2127. PMID: 4134761, PMCID: PMC388399, DOI: 10.1073/pnas.71.5.2123.Peer-Reviewed Original Research
1971
Involvement of Carbohydrate in the Immunochemical Determinant Area of HL-A Substances
SANDERSON A, CRESSWELL P, WELSH K. Involvement of Carbohydrate in the Immunochemical Determinant Area of HL-A Substances. Nature 1971, 230: 8-12. PMID: 4104302, DOI: 10.1038/newbio230008a0.Peer-Reviewed Original Research