2001
Defective Antigen Processing in GILT-Free Mice
Maric M, Arunachalam B, Phan U, Dong C, Garrett W, Cannon K, Alfonso C, Karlsson L, Flavell R, Cresswell P. Defective Antigen Processing in GILT-Free Mice. Science 2001, 294: 1361-1365. PMID: 11701933, DOI: 10.1126/science.1065500.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsAntigensCell LineDendritic CellsDisulfidesEpitopesHistocompatibility Antigens Class IIHybridomasHydrogen-Ion ConcentrationImmunizationMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMuramidaseOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsProtein ConformationProtein FoldingSpleenT-LymphocytesCathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*
Honey K, Duff M, Beers C, Brissette W, Elliott E, Peters C, Maric M, Cresswell P, Rudensky A. Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*. Journal Of Biological Chemistry 2001, 276: 22573-22578. PMID: 11306582, DOI: 10.1074/jbc.m101851200.Peer-Reviewed Original ResearchConceptsB cellsCathepsin SMajor histocompatibility complex (MHC) class II moleculesClass II presentation pathwayT cell responsesPeripheral lymphoid organsCathepsin L proteinClass II moleculesInvariant chain cleavageAntigenic peptide fragmentsDendritic cellsLymphoid organsLysosomal thiol reductaseAntigen presentationPresentation pathwayB lymphocytesCell responsesMature giltsΓ-interferon-inducible lysosomal thiol reductaseInvariant chainThiol reductaseInducible lysosomal thiol reductaseNovel mechanismCathepsin LCells
1999
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
Mommaas A, Mulder A, Jordens R, Out C, Tan M, Cresswell P, Kluin P, Koning F. Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules. European Journal Of Immunology 1999, 29: 571-580. PMID: 10064073, DOI: 10.1002/(sici)1521-4141(199902)29:02<571::aid-immu571>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsHuman epidermal Langerhans cellsEpidermal Langerhans cellsLangerhans cellsT cellsAntigen-specific T cellsMannose receptorPeripheral blood mononuclear cellsHLA class II moleculesProtein antigensBlood-derived DCsBlood mononuclear cellsAntigen-presenting cellsNaive T cellsDendritic cell lineageClass II moleculesClass II compartmentsFunctional mannose receptorsLymph nodesAntigen uptakeMononuclear cellsMHC classEndocytic capacitySkin damageReceptor-mediated endocytosis pathwayAntigen