1996
Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
Robbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM. Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesClass-II-associated invariant chain peptidesMHC-class-II-restricted antigen presentationMajor histocompatibility complex (MHC) class II moleculesMHC class IIInvariant chain peptidePercoll gradientAntigen presentationClass IIHLA-DMAntigenic peptidesInvariant chainPeptide loadingAlpha beta dimersChain peptideImmunoelectron micrographsDM moleculesBeta dimersCompartmentsProteolytic fragmentsEndocytic compartmentsIntracellular compartments
1995
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.Peer-Reviewed Original Research
1994
Antigen Presentation: Getting peptides into MHC class II molecules
Cresswell P. Antigen Presentation: Getting peptides into MHC class II molecules. Current Biology 1994, 4: 541-543. PMID: 7922377, DOI: 10.1016/s0960-9822(00)00119-6.Peer-Reviewed Original ResearchAssembly, Transport, and Function of MHC Class II Molecules
Cresswell P. Assembly, Transport, and Function of MHC Class II Molecules. Annual Review Of Immunology 1994, 12: 259-291. PMID: 8011283, DOI: 10.1146/annurev.iy.12.040194.001355.Peer-Reviewed Original ResearchConceptsII-invariant chain complexesEndosomal systemMembrane protein transportTrans-Golgi networkCell surfaceChain complexesAdditional gene productsAlpha beta dimersLate endosome/Beta dimersProtein transportCytoplasmic tailGene productsConstitutive pathwayEndosome/Golgi apparatusEndoplasmic reticulumInvariant chainMHC class II moleculesPrimary functionPrecise mechanismClass II moleculesComplexesPeptidesBind peptides