1997
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.Peer-Reviewed Original ResearchConceptsHLA-DOII-like moleculeAntigen processingClass IIHLA-DMMajor histocompatibility complex classMHC class IIHistocompatibility complex classClass II moleculesII-CLIP complexesHLA-DM functionT cell linesB cellsChain-derived peptideAntigenic peptidesImportant modulatorCell linesDM functionInvariant chain-derived peptidesComplex classNegative regulationPeptides
1996
Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM
Robbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM. Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesClass-II-associated invariant chain peptidesMHC-class-II-restricted antigen presentationMajor histocompatibility complex (MHC) class II moleculesMHC class IIInvariant chain peptidePercoll gradientAntigen presentationClass IIHLA-DMAntigenic peptidesInvariant chainPeptide loadingAlpha beta dimersChain peptideImmunoelectron micrographsDM moleculesBeta dimersCompartmentsProteolytic fragmentsEndocytic compartmentsIntracellular compartments