2014
A congenital disorder of deglycosylation: biochemical characterization of N‐glycanase 1 deficiency in patient fibroblasts (607.3)
He P, Ng B, Cresswell P, Grotzke J, Gunel M, Jafar‐Nejad H, Kodali V, Kaufman R, Freeze H. A congenital disorder of deglycosylation: biochemical characterization of N‐glycanase 1 deficiency in patient fibroblasts (607.3). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.607.3.Peer-Reviewed Original ResearchN-glycanase 1 (NGLY1) deficiencyN-glycanase 1Patient fibroblastsMisfolded glycoproteinsER stressPatient-derived fibroblastsFree oligosaccharidesSignal transductionProteasomal degradationBiochemical characterizationNGLY1Enzymatic activitySubstrate accumulationExome sequencingPhysiological conditionsDeglycosylationFibroblastsAbnormal liver functionGlycoproteinMutationsCongenital disorderPeripheral neuropathyLiver functionAltered size distributionTransduction
2001
Glycosylation and the Immune System
Rudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System. Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Antibody ReactionsAntigen-Presenting CellsAntigens, CD1Carrier ProteinsCollectinsComplement System ProteinsEndoplasmic ReticulumEpitopesGlycoproteinsGlycosylationHistocompatibility AntigensHumansImmune SystemImmunoglobulinsPolysaccharidesProtein FoldingT-LymphocytesViral Envelope ProteinsConceptsImmune systemMajor histocompatibility complex antigensAntigen-presenting cellsAdaptive immune responsesCellular immune systemHistocompatibility complex antigensHumoral immune systemT cell receptor complexRheumatoid arthritisMannose-binding lectinAutoimmune diseasesCell receptor complexT cellsImmune responseComplex antigensPeptide antigensComplement componentsImmunoglobulin GAntigenKey moleculesReceptor complexSpecific glycoformsGlycoproteinGlycopeptide antigensArthritis
1987
Regulation of HLA Class I and Class II antigen expression
Cresswell P. Regulation of HLA Class I and Class II antigen expression. British Medical Bulletin 1987, 43: 66-80. PMID: 3315102, DOI: 10.1093/oxfordjournals.bmb.a072177.Peer-Reviewed Original ResearchConceptsCell surfaceRegulatory genesTranscriptional levelHybridisation experimentsIntracellular transportThird glycoproteinHeterodimeric glycoproteinCell typesChondroitin sulfate proteoglycanEfficient assemblyCell linesSulfate proteoglycanEnhanced expressionT cell linesGenesClass IExpressionTissue distributionRegulationLymphoblastoid linesGlycoproteinUnusual complexityClass I moleculesInvariant chainBiosynthesis