Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression
Carrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression. Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.Peer-Reviewed Original ResearchConceptsGene expressionDNA methylationLymphoblastoid cell linesRegulatory mechanismsDNA hypomethylationParental linesHybrid linesSomatic cell hybridsRestriction enzyme Hpa IIHpa II digestionMsp I siteDifferent regulatory mechanismsCell hybridsGenomic probesGene inductionUnexpressed genesComplete demethylationHpa IIGenesDR genesMethylationT-LCLCell linesI siteHypomethylation