2008
An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs
Chari A, Golas MM, Klingenhäger M, Neuenkirchen N, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U. An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs. Cell 2008, 135: 497-509. PMID: 18984161, DOI: 10.1016/j.cell.2008.09.020.Peer-Reviewed Original ResearchConceptsSpliceosomal small nuclear ribonucleoproteinsSMN complexSm proteinsProtein unitsCore domainMRNA processing machinerySmall nuclear ribonucleoproteinSnRNP formationAssembly chaperonesPRMT5 complexClamp loaderNuclear ribonucleoproteinProcessing machinerySnRNAMode of actionPIClnStructural studiesProteinComplexesEssential componentPRMT5ChaperonesSnRNPRibonucleoproteinMachineryDeciphering the assembly pathway of Sm‐class U snRNPs
Neuenkirchen N, Chari A, Fischer U. Deciphering the assembly pathway of Sm‐class U snRNPs. FEBS Letters 2008, 582: 1997-2003. PMID: 18348870, DOI: 10.1016/j.febslet.2008.03.009.Peer-Reviewed Original ResearchConceptsU snRNPsAssembly pathwayUridine-rich small nuclear ribonucleoproteinsProtein arginine methyltransferase 5SMN complex functionTrans-acting factorsSmall nuclear ribonucleoproteinNuclear ribonucleoproteinCommon proteinsSurvival motor neuronSm classSnRNPsProteinPathwayMotor neuronsRibonucleoproteinRecent progressRNASMNAssemblyLarge numberVitroVivoComplexes
2006
A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) Complex*
Otter S, Grimmler M, Neuenkirchen N, Chari A, Sickmann A, Fischer U. A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) Complex*. Journal Of Biological Chemistry 2006, 282: 5825-5833. PMID: 17178713, DOI: 10.1074/jbc.m608528200.Peer-Reviewed Original ResearchConceptsMotor neurons (SMN) complexSMN complexComprehensive interaction mapInteraction mapSm proteinsSMN proteinSpinal muscular atrophy (SMA) disease geneRich small nuclear ribonucleoproteinSmall nuclear ribonucleoproteinAssembly machineryU snRNPsProtein SMNU snRNAsNuclear ribonucleoproteinDisease genesSm classGemins 2ProteinSnRNANovel assayModular compositionMultiple interactionsComplexesGemin5Major component