2015
Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice
Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, Asano S. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology 2015, 61: 1660-1671. PMID: 25311759, PMCID: PMC6083834, DOI: 10.1002/hep.27565.Peer-Reviewed Original ResearchConceptsBile duct proliferationIntrahepatic cholestasisDuct proliferationExtensive bile duct proliferationBiliary HCO3- concentrationImmortalized mouse cholangiocytesSevere intrahepatic cholestasisAquaporin-1Cystic fibrosis transmembrane conductance regulatorBile duct epitheliumBile acid accumulationSurface expressionBile duct morphologyReduced functional expressionPeriportal fibrosisBile ductInflammatory cellsBile flowCholestatic diseasePeriductular fibrosisBiliary epitheliumHepatic disordersAnion exchanger 2Useful modelVirus infection
2013
Chapter 80 Autosomal Dominant Polycystic Kidney Disease
Somlo S, Torres V, Caplan M. Chapter 80 Autosomal Dominant Polycystic Kidney Disease. 2013, 2645-2688. DOI: 10.1016/b978-0-12-381462-3.00080-x.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseKidney diseasePolycystic kidney diseaseStructural kidney diseaseMultiple renal cystsAortic root dilatationTherapeutic clinical trialsMitral valve prolapseAbdominal wall herniasLiver bile ductsAge-dependent occurrenceBasic disease mechanismsNoncystic manifestationsRoot dilatationBile ductPolycystic liverSystemic disordersValve prolapseExtrarenal manifestationsClinical trialsPancreatic ductWall herniasRenal cystsClinical disease