2005
A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis
Osterweil E, Wells D, Mooseker M. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. Journal Of Cell Biology 2005, 168: 329-338. PMID: 15657400, PMCID: PMC2171578, DOI: 10.1083/jcb.200410091.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex 2Adaptor Proteins, Signal TransducingAdenosine TriphosphateAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAstrocytesBrainBrain ChemistryDendritesDendritic SpinesDiscs Large Homolog 1 ProteinDyneinsEndocytosisFemaleGlial Fibrillary Acidic ProteinGuanylate KinasesInsulinMaleMembrane ProteinsMiceMice, Inbred C57BLMice, Mutant StrainsMicrofilament ProteinsMicroscopy, ElectronMyosin Heavy ChainsMyosin VIIaMyosinsNerve Tissue ProteinsNeuronsReceptors, AMPAReceptors, GlutamateSucroseSynapsesSynaptic MembranesSynaptosomesTransferrinConceptsHippocampal neuronsDendritic spinesIsoxazole propionic acid-type glutamate receptorsWild-type hippocampal neuronsShort dendritic spinesNumber of synapsesSynapse lossNeurons displaySynapse numberGlutamate receptorsNervous systemNonneuronal cellsPostsynaptic structuresSynaptic structurePostsynaptic densityDominant negative disruptionSignificant deficitsAstrogliosisNeuronsBrainMYO6SpineSynapsesReceptor endocytosisMyosin VI
2003
Myosin-Va Binds to and Mechanochemically Couples Microtubules to Actin Filaments
Cao T, Chang W, Masters S, Mooseker M. Myosin-Va Binds to and Mechanochemically Couples Microtubules to Actin Filaments. Molecular Biology Of The Cell 2003, 15: 151-161. PMID: 14565972, PMCID: PMC307536, DOI: 10.1091/mbc.e03-07-0504.Peer-Reviewed Original Research
2001
High Affinity Binding of Brain Myosin-Va to F-actin Induced by Calcium in the Presence of ATP*
Tauhata S, dos Santos D, Taylor E, Mooseker M, Larson R. High Affinity Binding of Brain Myosin-Va to F-actin Induced by Calcium in the Presence of ATP*. Journal Of Biological Chemistry 2001, 276: 39812-39818. PMID: 11517216, DOI: 10.1074/jbc.m102583200.Peer-Reviewed Original ResearchThe Yeast Class V Myosins, Myo2p and Myo4p, Are Nonprocessive Actin-Based Motors
Reck-Peterson S, Tyska M, Novick P, Mooseker M. The Yeast Class V Myosins, Myo2p and Myo4p, Are Nonprocessive Actin-Based Motors. Journal Of Cell Biology 2001, 153: 1121-1126. PMID: 11381095, PMCID: PMC2174330, DOI: 10.1083/jcb.153.5.1121.Peer-Reviewed Original ResearchActinsAdenosine TriphosphateAnimalsAntibodiesBrainCalciumCalmodulin-Binding ProteinsCarrier ProteinsChickensFungal ProteinsKineticsMicroscopy, VideoMolecular Motor ProteinsMovementMyosin Heavy ChainsMyosin Type IIMyosin Type VMyosinsNerve Tissue ProteinsProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe Proteins
2000
Myosin-V stepping kinetics: A molecular model for processivity
Rief M, Rock R, Mehta A, Mooseker M, Cheney R, Spudich J. Myosin-V stepping kinetics: A molecular model for processivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9482-9486. PMID: 10944217, PMCID: PMC16890, DOI: 10.1073/pnas.97.17.9482.Peer-Reviewed Original Research
1999
Myosin-V is a processive actin-based motor
Mehta A, Rock R, Rief M, Spudich J, Mooseker M, Cheney R. Myosin-V is a processive actin-based motor. Nature 1999, 400: 590-593. PMID: 10448864, DOI: 10.1038/23072.Peer-Reviewed Original Research
1998
Human myosin-IXb is a mechanochemically active motor and a GAP for rho
Post P, Bokoch G, Mooseker M. Human myosin-IXb is a mechanochemically active motor and a GAP for rho. Journal Of Cell Science 1998, 111: 941-950. PMID: 9490638, DOI: 10.1242/jcs.111.7.941.Peer-Reviewed Original ResearchActinsAdenosine TriphosphateAlternative SplicingAmino Acid SequenceAnimalsCalciumCalmodulinGTP PhosphohydrolasesGTP-Binding ProteinsGTPase-Activating ProteinsHumansLeukocytesMolecular Sequence DataMuscle ContractionMyosinsProtein BindingProteinsRas GTPase-Activating ProteinsRas ProteinsRatsRho GTP-Binding Proteins
1996
Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones
Wang F, Wolenski J, Cheney R, Mooseker M, Jay D. Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones. Science 1996, 273: 660-663. PMID: 8662560, DOI: 10.1126/science.273.5275.660.Peer-Reviewed Original Research
1994
Porcine myosin-VI: characterization of a new mammalian unconventional myosin.
Hasson T, Mooseker M. Porcine myosin-VI: characterization of a new mammalian unconventional myosin. Journal Of Cell Biology 1994, 127: 425-440. PMID: 7929586, PMCID: PMC2120210, DOI: 10.1083/jcb.127.2.425.Peer-Reviewed Original Research
1987
The 110-kD protein-calmodulin complex of the intestinal microvillus is an actin-activated MgATPase.
Conzelman K, Mooseker M. The 110-kD protein-calmodulin complex of the intestinal microvillus is an actin-activated MgATPase. Journal Of Cell Biology 1987, 105: 313-324. PMID: 2956266, PMCID: PMC2114910, DOI: 10.1083/jcb.105.1.313.Peer-Reviewed Original Research
1985
Role of myosin in terminal web contraction in isolated intestinal epithelial brush borders.
Keller T, Conzelman K, Chasan R, Mooseker M. Role of myosin in terminal web contraction in isolated intestinal epithelial brush borders. Journal Of Cell Biology 1985, 100: 1647-1655. PMID: 3988804, PMCID: PMC2113869, DOI: 10.1083/jcb.100.5.1647.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsChickensIntestinal MucosaMicrovilliMyosinsPhosphorylationProtein BindingSolubility
1984
Brush border cytoskeleton and integration of cellular functions.
Mooseker M, Bonder E, Conzelman K, Fishkind D, Howe C, Keller T. Brush border cytoskeleton and integration of cellular functions. Journal Of Cell Biology 1984, 99: 104s-112s. PMID: 6378918, PMCID: PMC2275581, DOI: 10.1083/jcb.99.1.104s.Peer-Reviewed Original ResearchThe cytoskeletal apparatus of the intestinal brush border.
Mooseker M, Bonder E, Conzelman K, Fishkind D, Howe C, Keller T. The cytoskeletal apparatus of the intestinal brush border. Kroc Foundation Series 1984, 17: 287-307. PMID: 6392486.Peer-Reviewed Original ResearchAdenosine TriphosphateAnimalsCalciumCytoskeletonHumansIntestinesMicrofilament ProteinsMicrovilliMyosinsCalcium-dependent regulation of cytoskeletal structure and contractility in the intestinal brush border.
Mooseker M. Calcium-dependent regulation of cytoskeletal structure and contractility in the intestinal brush border. Progress In Clinical And Biological Research 1984, 168: 179-86. PMID: 6542665.Peer-Reviewed Original Research
1983
Characterization of the 110-kdalton actin-calmodulin-, and membrane-binding protein from microvilli of intestinal epithelial cells.
Howe C, Mooseker M. Characterization of the 110-kdalton actin-calmodulin-, and membrane-binding protein from microvilli of intestinal epithelial cells. Journal Of Cell Biology 1983, 97: 974-985. PMID: 6311843, PMCID: PMC2112603, DOI: 10.1083/jcb.97.4.974.Peer-Reviewed Original ResearchMechanism of brush border contractility studied by the quick-freeze, deep-etch method.
Hirokawa N, Keller T, Chasan R, Mooseker M. Mechanism of brush border contractility studied by the quick-freeze, deep-etch method. Journal Of Cell Biology 1983, 96: 1325-1336. PMID: 6601660, PMCID: PMC2112654, DOI: 10.1083/jcb.96.5.1325.Peer-Reviewed Original Research
1982
Ca++-calmodulin-dependent phosphorylation of myosin, and its role in brush border contraction in vitro.
Keller T, Mooseker M. Ca++-calmodulin-dependent phosphorylation of myosin, and its role in brush border contraction in vitro. Journal Of Cell Biology 1982, 95: 943-959. PMID: 6897550, PMCID: PMC2112925, DOI: 10.1083/jcb.95.3.943.Peer-Reviewed Original ResearchConceptsBrush border contractionBrush borderIntestinal epithelial cellsEpithelial cellsCalmodulin activityBrush border proteinsMyosin light chain kinaseContractionDegrees CLight chain kinaseLight chainCalmodulin-dependent phosphorylationBrush border myosinPhosphorylationDalton light chainChain kinaseTerminal web
1976
Brush border motility. Microvillar contraction in triton-treated brush borders isolated from intestinal epithelium.
Mooseker M. Brush border motility. Microvillar contraction in triton-treated brush borders isolated from intestinal epithelium. Journal Of Cell Biology 1976, 71: 417-433. PMID: 11222, PMCID: PMC2109748, DOI: 10.1083/jcb.71.2.417.Peer-Reviewed Original Research
1973
ISOLATION AND REACTIVATION OF THE AXOSTYLE
Mooseker M, Tilney L. ISOLATION AND REACTIVATION OF THE AXOSTYLE. Journal Of Cell Biology 1973, 56: 13-26. PMID: 4345162, PMCID: PMC2108841, DOI: 10.1083/jcb.56.1.13.Peer-Reviewed Original Research