Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer
Moser C, Rüdiger D, Förster F, von Blume J, Yu P, Kuster B, Kazmaier U, Vollmar AM, Zahler S. Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer. Scientific Reports 2017, 7: 16407. PMID: 29180826, PMCID: PMC5703899, DOI: 10.1038/s41598-017-16759-7.Peer-Reviewed Original ResearchConceptsCell migrationActin-targeting drugsActin-binding compoundsSub-toxic dosesTumor cell migrationProteomic approachSRF signalingNuclear stiffnessActin filament stabilizerProtein clustersActin filamentsH treatmentComplex biologyProtein expressionActinPersistent morphological changesSmall moleculesMiuraenamidesGeneral cytotoxicityNatural compoundsCytotoxic effectsRegulationMorphological changesBoyden chamberMigration