Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells
Lebreton S, Paladino S, Liu D, Nitti M, von Blume J, Pinton P, Zurzolo C. Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2014709118. PMID: 34389665, PMCID: PMC8379914, DOI: 10.1073/pnas.2014709118.Peer-Reviewed Original ResearchConceptsApical sortingGPI-APsCholesterol-dependent clusteringGolgi-resident proteinsPlasma membrane organizationPolarized epithelial cellsEpithelial cellsDiverse vital functionsResident proteinsMolecular machinerySecretory cargoMembrane organizationGolgi eventUnexpected roleGolgi complexSpecific machineryGolgiBasolateral surfaceApical surfaceCab45SPCA1Vital functionsMachinerySortingProteinSending out molecules from the TGN
Ramazanov BR, Tran ML, von Blume J. Sending out molecules from the TGN. Current Opinion In Cell Biology 2021, 71: 55-62. PMID: 33706234, PMCID: PMC8328904, DOI: 10.1016/j.ceb.2021.02.005.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkEndoplasmic reticulum contact sitesCell-cell communicationExtracellular matrix proteinsMembrane traffickingCargo proteinsCargo sortingTGN structureTransmembrane proteinPlasma membraneContact sitesExciting linkSoluble proteinMatrix proteinsSorting mechanismProteinTransport carriersMajor open questionsSortingMembraneNovel typeTraffickingMachineryOrganismsVesicles