2018
Exploring new routes for secretory protein export from the trans-Golgi network
Pakdel M, von Blume J. Exploring new routes for secretory protein export from the trans-Golgi network. Molecular Biology Of The Cell 2018, 29: 235-240. PMID: 29382805, PMCID: PMC5996961, DOI: 10.1091/mbc.e17-02-0117.Peer-Reviewed Original ResearchConceptsSecretory cargoSecretory proteinsCytoplasmic actin cytoskeletonMajor sorting stationTrans-Golgi networkGolgi residentsProtein exportGolgi networkActin cytoskeletonATPase SPCA1Cellular compartmentsTissue homeostasisSorting stationSoluble proteinTGNLysosomal hydrolasesOverall pathwayLuminal CaRecent discoveryProteinCargoSpecific carrierSortingCellsFinal destination
2017
Cab45—Unraveling key features of a novel secretory cargo sorter at the trans-Golgi network
Blank B, von Blume J. Cab45—Unraveling key features of a novel secretory cargo sorter at the trans-Golgi network. European Journal Of Cell Biology 2017, 96: 383-390. PMID: 28372832, DOI: 10.1016/j.ejcb.2017.03.001.Peer-Reviewed Original ResearchConceptsMolecular functionsCargo moleculesCytoplasmic actin cytoskeletonSpecific cargo moleculesTransmembrane cargo receptorsTrans-Golgi networkMannose-6-phosphate receptorCargo receptorsGolgi networkActin cytoskeletonATPase SPCA1Secreted proteinsPlasma membraneSecretory proteinsExtracellular proteasesCab45Sorting mechanismSurface receptorsProteinExtracellular spaceSpecific carrierPossible roleFinal destinationSortingReceptors
2008
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells
von Wichert G, Edenfeld T, von Blume J, Krisp H, Krndija D, Schmid H, Oswald F, Lother U, Walther P, Adler G, Seufferlein T. Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. Cellular Signalling 2008, 20: 925-934. PMID: 18262756, DOI: 10.1016/j.cellsig.2008.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceBiological Transport, ActiveCell Line, TumorChromogranin AGolgi ApparatusHumansMolecular Sequence DataNeuroendocrine TumorsProtein Kinase D2Protein Kinase InhibitorsProtein KinasesRNA, Small InterferingSecretory VesiclesSignal TransductionTrans-Golgi NetworkConceptsTrans-Golgi networkNeuroendocrine tumor cellsGolgi networkFunctional neuroendocrine tumorsProtein kinase D (PKD) familyGolgi apparatusProtein kinase D2Secretory granulesTumor cellsSerine-threonine kinaseHormone secretionNeuroendocrine tumorsChromogranin APerinuclear retentionThreonine kinaseSecretory vesiclesPrecise regulationAutonomous hormone secretionD family