2024
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
Harrison A, Yang D, Cahoon J, Geng T, Cao Z, Karginov T, Hu Y, Li X, Chiari C, Qyang Y, Vella A, Fan Z, Vanaja S, Rathinam V, Witczak C, Bogan J, Wang P. UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Nature Immunology 2024, 25: 2234-2246. PMID: 39567760, DOI: 10.1038/s41590-024-02004-7.Peer-Reviewed Original ResearchConceptsRIG-I-like receptorsRIG-I-like receptor signalingCytosolic RIG-I-like receptorsAntiviral immunityPlasma membrane tetheringRNA virus infectionGlucose transportInnate antiviral immunityCytoplasmic RIG-I-like receptorsGolgi matrixGLUT4 translocationRLR signalingViral RNACell surfaceGLUT4GLUT4 expressionGlucose uptakeInterferon responseRNAGlycolytic reprogrammingVirus infectionHuman inflammatory myopathiesGolgiSignalUbiquitin
2019
Acylation – A New Means to Control Traffic Through the Golgi
Ernst AM, Toomre D, Bogan JS. Acylation – A New Means to Control Traffic Through the Golgi. Frontiers In Cell And Developmental Biology 2019, 7: 109. PMID: 31245373, PMCID: PMC6582194, DOI: 10.3389/fcell.2019.00109.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDiverse protein clientsSorting of proteinsIntegral membrane proteinsProtein clientsS-acylationGolgi networkProtein adaptersMembrane proteinsAnterograde fluxLipid modificationGolgi cisternaeGolgiLipid acylationNeurodegenerative diseasesHuman physiologyProteinPotential relevanceOrganellesRecent dataRapid trafficAcylationCisternaePhysiologyCargoMechanism