Featured Publications
Nucleation by rRNA Dictates the Precision of Nucleolus Assembly
Falahati H, Pelham-Webb B, Blythe S, Wieschaus E. Nucleation by rRNA Dictates the Precision of Nucleolus Assembly. Current Biology 2016, 26: 277-285. PMID: 26776729, PMCID: PMC5866055, DOI: 10.1016/j.cub.2015.11.065.Peer-Reviewed Original ResearchConceptsMembrane-less organellesTranscription of rRNANucleolar proteinsCellular functionsNucleolus formationInitial assemblyD. melanogaster embryosDifferent cellular functionsSpecific cellular functionsWild-type embryosRole of rRNARibosomal biogenesisNucleolus assemblySuch organellesNucleoplasmic concentrationIntracellular compartmentsRRNAOrganellesSpatiotemporal precisionTranscriptionNucleoliEmbryosProteinAssemblyBiological systems
2016
Mitosis-associated repression in development
Esposito E, Lim B, Guessous G, Falahati H, Levine M. Mitosis-associated repression in development. Genes & Development 2016, 30: 1503-1508. PMID: 27401553, PMCID: PMC4949323, DOI: 10.1101/gad.281188.116.Peer-Reviewed Original ResearchConceptsSequence-specific repressorsEarly Drosophila embryoLive-imaging methodsMitotic silencingSnail repressionAnimal developmentSnail repressorDrosophila embryosNascent transcriptsNeurogenic ectodermTranscriptional repressionTarget enhancersPresumptive mesodermReporter geneRepressionRepressorMesodermTranscriptionMitosisEmbryosBroad patternsPervasive featureSilencingEctodermGenes